Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C35H46O20 |
Molecular Weight | 786.7277 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 15 / 15 |
E/Z Centers | 1 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](OCCC3=CC(O)=C(O)C=C3)O[C@H](CO[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@H]2OC(=O)\C=C\C5=CC(O)=C(O)C=C5)[C@H](O)[C@H](O)[C@H]1O
InChI
InChIKey=FSBUXLDOLNLABB-ISAKITKMSA-N
InChI=1S/C35H46O20/c1-14-24(42)26(44)29(47)35(51-14)55-32-30(48)34(49-9-8-16-3-6-18(38)20(40)11-16)53-22(13-50-33-28(46)27(45)25(43)21(12-36)52-33)31(32)54-23(41)7-4-15-2-5-17(37)19(39)10-15/h2-7,10-11,14,21-22,24-40,42-48H,8-9,12-13H2,1H3/b7-4+/t14-,21+,22+,24-,25+,26+,27-,28+,29+,30+,31+,32+,33+,34+,35-/m0/s1
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/19459316Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/25077780 | https://www.ncbi.nlm.nih.gov/pubmed/27659301 | https://www.ncbi.nlm.nih.gov/pubmed/22805084
Sources: https://www.ncbi.nlm.nih.gov/pubmed/19459316
Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/25077780 | https://www.ncbi.nlm.nih.gov/pubmed/27659301 | https://www.ncbi.nlm.nih.gov/pubmed/22805084
Echinacoside is a caffeic acid glycoside which is constituted from a trisaccharide consisting of two glucose and one rhamnose moieties glycosidically linked to one caffeic acid and on hydroxytyrosol residue at the centrally situated rhamnose. Echinacoside is the basic component of the roots of E. angustifolia and E. pallida, ranging from 0.5 to 1.0%. Echinacoside is reported to possess the immunostimulatory and high antioxidant activities
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22805084
Curator's Comment: Known to be CNS active in rats. Human data not available.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: WP1045 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29033543 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
|||
Primary | Unknown Approved UseUnknown |
|||
Primary | Unknown Approved UseUnknown |
Overview
CYP3A4 | CYP2C9 | CYP2D6 | hERG |
---|---|---|---|
Drug as perpetrator​
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
inconclusive [IC50 7.9433 uM] | ||||
no [Activation 7.9433 uM] | ||||
Sources: https://pubmed.ncbi.nlm.nih.gov/33730506/ |
no | |||
no | ||||
no | ||||
no | ||||
unlikely [IC50 6290 uM] | ||||
Sources: https://pubmed.ncbi.nlm.nih.gov/33730506/ |
yes | |||
yes |
Drug as victim
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
yes |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22805084
Rats were treated with Echinacoside at doses 20, 40 and 80 mg/kg/day
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25341567
Rat pulmonary artery smooth muscle cells were incubated under normoxia, hypoxia, hypoxia + 0.35 mM echinacoside, or hypoxia + 0.4 mM echinacoside for 24 h. Cell viability was assessed by MTS assays.
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DB15488
Created by
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82854-37-3
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737806-07-4
Created by
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5281771
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DTXSID0033469
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1231750
Created by
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Echinacoside
Created by
admin on Sat Dec 16 08:32:11 GMT 2023 , Edited by admin on Sat Dec 16 08:32:11 GMT 2023
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I04O1DT48T
Created by
admin on Sat Dec 16 08:32:11 GMT 2023 , Edited by admin on Sat Dec 16 08:32:11 GMT 2023
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SUBSTANCE RECORD