U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula 2Na.O3S2.5H2O
Molecular Weight 248.184
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM THIOSULFATE

SMILES

O.O.O.O.O.[Na+].[Na+].[O-]S([S-])(=O)=O

InChI

InChIKey=PODWXQQNRWNDGD-UHFFFAOYSA-L
InChI=1S/2Na.H2O3S2.5H2O/c;;1-5(2,3)4;;;;;/h;;(H2,1,2,3,4);5*1H2/q2*+1;;;;;;/p-2

HIDE SMILES / InChI
Sodium thiosulfate (sodium thiosulphate/STS) is a chemical and medication. As a medication, it is used in combination with sodium nitrite under the trade name to NITHIODOTE treat cyanide poisoning. The primary route of endogenous cyanide detoxification is by enzymatic transulfuration to thiocyanate (SCN- ), which is relatively nontoxic and readily excreted in the urine. Sodium thiosulfate is thought to serve as a sulfur donor in the reaction catalyzed by the enzyme rhodanese, thus enhancing the endogenous detoxification of cyanide. In addition, Sodium thiosulfate is used in calciphylaxis in hemodialysis patients with end-stage kidney disease. Calciphylaxis is vasculopathy characterized by ischemia and painful skin necrosis due to calcification and intimal fibroplasia of thrombosis of the panicular arterioles. Sodium thiosulfate is used as treatment due to its antioxidant activity and as a chelating. Sodium thiosulfate renders renal protection by modulating the mitochondrial KATP channel for preventing urolithiasis. Moreover, STS was assumed to play a vital role in on ischemia reperfusion injury (IR). The effectiveness of STS as a cardioprotective agent was attributed to the reduction of apoptosis by binding to the active site of caspase-3 in silico, which was substantiated by the reduced expression of caspase-3 and poly ADP ribose polymerase levels.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P42574
Gene ID: 836.0
Gene Symbol: CASP3
Target Organism: Homo sapiens (Human)
Target ID: Q15842
Gene ID: 3764.0
Gene Symbol: KCNJ8
Target Organism: Homo sapiens (Human)
Target ID: Q14654
Gene ID: 3767.0
Gene Symbol: KCNJ11
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
NITHIODOTE

Approved Use

Sodium nitrite and sodium thiosulfate are indicated for sequential use for treatment of acute cyanide poisoning that is judged to be lifethreatening. Use with caution if the diagnosis of cyanide poisoning is uncertain.

Launch Date

2011
Palliative
Unknown

Approved Use

Unknown
Preventing
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Sucrose teepol tellurite agar: a new selective indicator medium for isolation of Vibrio species.
1977 Apr
Nutritional aspects of dissimilatory sulfate reduction in the human large intestine.
1997 Nov
Patents

Sample Use Guides

acute cyanide intoxication: Adults: 1.) Sodium Nitrite -10 mL of a 3% solution (300 mg) of sodium nitrite at the rate of 2.5 to 5 mL/minute 2.) Sodium Thiosulfate - 50 mL of a 25% solution (12.5 g) of a sodium thiosulfate solution immediately following administration of sodium nitrite. Children: 1.) Sodium Nitrite -0.2 mL/kg of a 3% solution (6 mg/kg or 6-8 mL/m2 BSA) of sodium nitrite at the rate of 2.5 to 5 mL/minute not to exceed 10 mL (300 mg) 2.) Sodium Thiosulfate - 1 mL/kg of body weight using a 25% solution (250 mg/kg or approximately 30-40 mL/m2 of BSA) not to exceed 50 mL (12.5 g) total dose immediately following administration of sodium nitrite.
Route of Administration: Intravenous
There were investigated the effectiveness of Sodium thiosulfate (STS) as a cardioprotective agent is attributed to the reduction of apoptosis by binding to the active site of caspase-3 in silico, which was substantiated by the reduced expression of caspase-3 and poly ADP ribose polymerase levels. STS of 1 mM recovered H9C2 cells from glucose oxidase/catalase-induced apoptosis. The isolated rat heart treated with STS prior to reperfusion injury (IR) injury improved its hemodynamics and reduced the infarct size to 9%. An in silico docking analysis revealed higher binding affinity of STS for caspase-3 with a binding energy of - 60.523 kcal/mol for the complex.
Name Type Language
SODIUM THIOSULFATE
EP   FCC   II   INCI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-IP  
INCI  
Official Name English
SODIUM THIOSULFATE [II]
Common Name English
SODIUM THIOSULFATE [USP-RS]
Common Name English
SODIUM THIOSULFATE [FCC]
Common Name English
SODIUM THIOSULFATE HYDRATE
JAN  
Systematic Name English
NSC-45624
Code English
NITHIODOTE COMPONENT SODIUM THIOSULFATE
Common Name English
SODIUM THIOSULFATE [INCI]
Common Name English
SODIUM THIOSULFATE [VANDF]
Common Name English
SODIUM THIOSULFATE [USP MONOGRAPH]
Common Name English
SODIUM THIOSULFATE [WHO-IP]
Common Name English
SODIUM THIOSULFATE [ORANGE BOOK]
Common Name English
SODIUM THIOSULFATE [EP MONOGRAPH]
Common Name English
THIOSULFURIC ACID, DISODIUM SALT, PENTAHYDRATE
Common Name English
SODIUM THIOSULPHATE
Systematic Name English
SODIUM THIOSULFATE PENTAHYDRATE [MI]
Common Name English
SODIUM THIOSULFATE PENTAHYDRATE
MI   WHO-DD  
Systematic Name English
Disodium thiosulfate pentahydrate
Systematic Name English
NATRII THIOSULFAS [WHO-IP LATIN]
Common Name English
DB-020
Code English
Sodium thiosulfate pentahydrate [WHO-DD]
Common Name English
SODIUM THIOSULFATE HYDRATE [JAN]
Common Name English
SODIUM THIOSULPHATE PENTAHYDRATE
Systematic Name English
SODIUM THIOSULFATE COMPONENT OF NITHIODOTE
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 80104
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WHO-ESSENTIAL MEDICINES LIST 4.2
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FDA ORPHAN DRUG 244207
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FDA ORPHAN DRUG 322410
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FDA ORPHAN DRUG 239207
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EU-Orphan Drug EU/3/14/1414
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FDA ORPHAN DRUG 479415
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FDA ORPHAN DRUG 9585
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FDA ORPHAN DRUG 381912
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FDA ORPHAN DRUG 450114
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FDA ORPHAN DRUG 177303
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WHO-ESSENTIAL MEDICINES LIST 13.1
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FDA ORPHAN DRUG 225606
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FDA ORPHAN DRUG 352611
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FDA ORPHAN DRUG 233306
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FDA ORPHAN DRUG 353311
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FDA ORPHAN DRUG 232506
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FDA ORPHAN DRUG 356511
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FDA ORPHAN DRUG 335311
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NCI_THESAURUS C26170
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CFR 21 CFR 184.1807
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Code System Code Type Description
EVMPD
SUB22204
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PRIMARY
CHEBI
32150
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PRIMARY
EPA CompTox
DTXSID6044197
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PRIMARY
WIKIPEDIA
SODIUM THIOSULFATE
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PRIMARY
MERCK INDEX
m10091
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PRIMARY Merck Index
PUBCHEM
61475
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PRIMARY
CAS
10102-17-7
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PRIMARY
RS_ITEM_NUM
1615107
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PRIMARY
RXCUI
36726
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PRIMARY RxNorm
NSC
45624
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PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
SODIUM THIOSULFATE
Created by admin on Fri Dec 15 15:57:04 GMT 2023 , Edited by admin on Fri Dec 15 15:57:04 GMT 2023
PRIMARY Description: Transparent, colourless crystals; odourless. Solubility: Very soluble in water; practically insoluble in ethanol (~750 g/l) TS. Category: Antidote. Storage: Sodium thiosulfate should be kept in a tightly closed container. Additional information: Sodium thiosulfate effloresces in dry air at temperatures exceeding 33?C and dissolves in its water of crystallization at about 49?C. Definition: Sodium thiosulfate contains not less than 99.0% and not more than 101.0% of Na2S2O3,5H2O.
ChEMBL
CHEMBL1208642
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PRIMARY
FDA UNII
HX1032V43M
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PRIMARY
DRUG BANK
DBSALT002504
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PRIMARY
NCI_THESAURUS
C1230
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PRIMARY
DAILYMED
HX1032V43M
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PRIMARY
DRUG CENTRAL
4518
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PRIMARY
MESH
C017717
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PRIMARY
EVMPD
SUB15332MIG
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PRIMARY