SODIUM THIOSULFATE

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	2Na.O3S2.5H2O
Molecular Weight	248.184
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.O.O.O.O.[Na+].[Na+].[O-]S([S-])(=O)=O

InChI

InChIKey=PODWXQQNRWNDGD-UHFFFAOYSA-L

InChI=1S/2Na.H2O3S2.5H2O/c;;1-5(2,3)4;;;;;/h;;(H2,1,2,3,4);5*1H2/q2*+1;;;;;;/p-2

HIDE SMILES / InChI

Molecular Formula	H2O3S2
Molecular Weight	114.144
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	H2O
Molecular Weight	18.0153
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/201444s000lbl.pdf | https://www.ncbi.nlm.nih.gov/pubmed/26742969 | https://www.ncbi.nlm.nih.gov/pubmed/28825580

Sodium thiosulfate (sodium thiosulphate/STS) is a chemical and medication. As a medication, it is used in combination with sodium nitrite under the trade name to NITHIODOTE treat cyanide poisoning. The primary route of endogenous cyanide detoxification is by enzymatic transulfuration to thiocyanate (SCN- ), which is relatively nontoxic and readily excreted in the urine. Sodium thiosulfate is thought to serve as a sulfur donor in the reaction catalyzed by the enzyme rhodanese, thus enhancing the endogenous detoxification of cyanide. In addition, Sodium thiosulfate is used in calciphylaxis in hemodialysis patients with end-stage kidney disease. Calciphylaxis is vasculopathy characterized by ischemia and painful skin necrosis due to calcification and intimal fibroplasia of thrombosis of the panicular arterioles. Sodium thiosulfate is used as treatment due to its antioxidant activity and as a chelating. Sodium thiosulfate renders renal protection by modulating the mitochondrial KATP channel for preventing urolithiasis. Moreover, STS was assumed to play a vital role in on ischemia reperfusion injury (IR). The effectiveness of STS as a cardioprotective agent was attributed to the reduction of apoptosis by binding to the active site of caspase-3 in silico, which was substantiated by the reduced expression of caspase-3 and poly ADP ribose polymerase levels.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Caspase-3 21 Target ID: P42574 Gene ID: 836.0 Gene Symbol: CASP3 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/28965151	Binding Agent 1064
ATP-sensitive inward rectifier potassium channel 8 9 Target ID: Q15842 Gene ID: 3764.0 Gene Symbol: KCNJ8 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/26742969	Modulator 828
ATP-sensitive inward rectifier potassium channel 11 10 Target ID: Q14654 Gene ID: 3767.0 Gene Symbol: KCNJ11 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/26742969	Modulator 828

Conditions

Condition	Modality	Highest Phase	Product
Acute cyanide poisoning 9 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/201444s000lbl.pdf	Curative	Approved 8429	NITHIODOTE Approved Use Sodium nitrite and sodium thiosulfate are indicated for sequential use for treatment of acute cyanide poisoning that is judged to be lifethreatening. Use with caution if the diagnosis of cyanide poisoning is uncertain. Launch Date 1.2948768E12
Calciphylaxis 7 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28825580	Palliative	Phase III 656	Unknown Approved Use Unknown
Nephrolithiasis 23 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19369406	Preventing	Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
METABOLISM, TOXICITY AND MANNER OF ACTION OF GOLD COMPOUNDS USED IN THE TREATMENT OF ARTHRITIS. I. HUMAN PLASMA AND SYNOVIAL FLUID CONCENTRATION AND URINARY EXCRETION OF GOLD DURING AND FOLLOWING TREATMENT WITH GOLD SODIUM THIOMALATE, GOLD SODIUM THIOSULFATE, AND COLLOIDAL GOLD SULFIDE.	1941 Jul	16694848
Selective vs. nonselective media and direct plating vs. enrichment technique in isolation of Vibrio cholerae: recommendations for clinical laboratories.	1980 Sep	7003031
Sodium thiosulfate disposition in humans: relation to sodium nitroprusside toxicity.	1983 Jan	6600205
Determination of thiosulfate in body fluids by GC and GC/MS.	1991 May-Jun	1943059
Application of new fluorescent thiol reagent to diagnosis of homocystinuria.	1991 Oct 26	1681358
Nutritional aspects of dissimilatory sulfate reduction in the human large intestine.	1997 Nov	9462959
Creation of transdermal pathways for macromolecule transport by skin electroporation and a low toxicity, pathway-enlarging molecule.	1999 Oct	10619443
Gestational urinary hyperthiosulfaturia protects hypercalciuric normal pregnant women from nephrolithiasis.	2004	15783122

Patents

Sample Use Guides

In Vivo Use Guide

acute cyanide intoxication: Adults: 1.) Sodium Nitrite -10 mL of a 3% solution (300 mg) of sodium nitrite at the rate of 2.5 to 5 mL/minute 2.) Sodium Thiosulfate - 50 mL of a 25% solution (12.5 g) of a sodium thiosulfate solution immediately following administration of sodium nitrite. Children: 1.) Sodium Nitrite -0.2 mL/kg of a 3% solution (6 mg/kg or 6-8 mL/m2 BSA) of sodium nitrite at the rate of 2.5 to 5 mL/minute not to exceed 10 mL (300 mg) 2.) Sodium Thiosulfate - 1 mL/kg of body weight using a 25% solution (250 mg/kg or approximately 30-40 mL/m2 of BSA) not to exceed 50 mL (12.5 g) total dose immediately following administration of sodium nitrite.

Route of Administration: Intravenous

In Vitro Use Guide

There were investigated the effectiveness of Sodium thiosulfate (STS) as a cardioprotective agent is attributed to the reduction of apoptosis by binding to the active site of caspase-3 in silico, which was substantiated by the reduced expression of caspase-3 and poly ADP ribose polymerase levels. STS of 1 mM recovered H9C2 cells from glucose oxidase/catalase-induced apoptosis. The isolated rat heart treated with STS prior to reperfusion injury (IR) injury improved its hemodynamics and reduced the infarct size to 9%. An in silico docking analysis revealed higher binding affinity of STS for caspase-3 with a binding energy of - 60.523 kcal/mol for the complex.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:57:04 UTC 2023` Edited by `admin` on `Fri Dec 15 15:57:04 UTC 2023`
Record UNII	HX1032V43M
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SODIUM THIOSULFATE

Official Name

English

SODIUM THIOSULFATE [II]

Common Name

English

SODIUM THIOSULFATE [USP-RS]

Common Name

English

SODIUM THIOSULFATE [FCC]

Common Name

English

SODIUM THIOSULFATE HYDRATE

Systematic Name

English

NSC-45624

Code

English

NITHIODOTE COMPONENT SODIUM THIOSULFATE

Common Name

English

SODIUM THIOSULFATE [INCI]

Common Name

English

SODIUM THIOSULFATE [VANDF]

Common Name

English

SODIUM THIOSULFATE [USP MONOGRAPH]

Common Name

English

SODIUM THIOSULFATE [WHO-IP]

Common Name

English

SODIUM THIOSULFATE [ORANGE BOOK]

Common Name

English

SODIUM THIOSULFATE [EP MONOGRAPH]

Common Name

English

THIOSULFURIC ACID, DISODIUM SALT, PENTAHYDRATE

Common Name

English

SODIUM THIOSULPHATE

Systematic Name

English

SODIUM THIOSULFATE PENTAHYDRATE [MI]

Common Name

English

SODIUM THIOSULFATE PENTAHYDRATE

Systematic Name

English

Disodium thiosulfate pentahydrate

Systematic Name

English

NATRII THIOSULFAS [WHO-IP LATIN]

Common Name

English

DB-020

Code

English

Sodium thiosulfate pentahydrate [WHO-DD]

Common Name

English

SODIUM THIOSULFATE HYDRATE [JAN]

Common Name

English

SODIUM THIOSULPHATE PENTAHYDRATE

Systematic Name

English

SODIUM THIOSULFATE COMPONENT OF NITHIODOTE

Common Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

80104