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Details

Stereochemistry ACHIRAL
Molecular Formula C12H9NO2
Molecular Weight 199.2054
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DICTAMNINE

SMILES

COC1=C2C=COC2=NC3=C1C=CC=C3

InChI

InChIKey=WIONIXOBNMDJFJ-UHFFFAOYSA-N
InChI=1S/C12H9NO2/c1-14-11-8-4-2-3-5-10(8)13-12-9(11)6-7-15-12/h2-7H,1H3

HIDE SMILES / InChI

Description

Dictamnine, a furoquinoline alkaloid isolated from the root bark of Dictamnus dasycarpus Turcz. (Rutaceae) is reported to have a wide range of pharmacological activities. Dictamnine is a strong mutagen and phototoxic alkaloid with DNA as a cellular target.

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Binding Agent
1064
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
2002 Mar 13
A new prenylated arylnaphthalene lignan from Haplophyllum myrtifolium.
2003 Sep
cis-Dihydrodiol, arene oxide and phenol metabolites of dictamnine: key intermediates in the biodegradation and biosynthesis of furoquinoline alkaloids.
2005 Aug 21
Furoquinoline alkaloids from the southern African Rutaceae Teclea natalensis.
2005 Mar
Solar simulator-induced phototoxicity of the furoquinoline alkaloid dictamnine compared to 8-methoxypsoralen and 5-methoxypsoralen.
2006 Aug
Pressurized liquid extraction followed by high-performance liquid chromatography for determination of seven active compounds in Cortex Dictamni.
2006 Mar 10
Isolation of secondary metabolites from Hortia oreadica (Rutaceae) leaves through high-speed counter-current chromatography.
2009 May 8
[Simultaneous determination of three active compounds in root barks of Dictamnus dasycarpus by RP-HPLC].
2010 Jan

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Curator's Comment: In vitro, labeled dictamnine was shown to form covalent monoadducts with purified DNA from M. hiemalis in the presence of long-wave ultraviolet light.
Unknown
Name Type Language
DICTAMNINE
MI  
Common Name English
DICTAMNINE [MI]
Common Name English
DICTAMINE
Common Name English
4-METHOXYFURO(2,3-B)QUINOLINE
Systematic Name English
Code System Code Type Description
PUBCHEM
68085
Created by admin on Fri Dec 15 19:48:17 GMT 2023 , Edited by admin on Fri Dec 15 19:48:17 GMT 2023
PRIMARY
CAS
484-29-7
Created by admin on Fri Dec 15 19:48:17 GMT 2023 , Edited by admin on Fri Dec 15 19:48:17 GMT 2023
PRIMARY
FDA UNII
HQZ3798D0A
Created by admin on Fri Dec 15 19:48:17 GMT 2023 , Edited by admin on Fri Dec 15 19:48:17 GMT 2023
PRIMARY
MERCK INDEX
m4369
Created by admin on Fri Dec 15 19:48:17 GMT 2023 , Edited by admin on Fri Dec 15 19:48:17 GMT 2023
PRIMARY Merck Index
EPA CompTox
DTXSID0041012
Created by admin on Fri Dec 15 19:48:17 GMT 2023 , Edited by admin on Fri Dec 15 19:48:17 GMT 2023
PRIMARY
SUBSTANCE RECORD
Structure of DICTAMNINE
NIH
NCATS
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