DICTAMNINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H9NO2
Molecular Weight	199.2054
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=C2C=COC2=NC3=C1C=CC=C3

InChI

InChIKey=WIONIXOBNMDJFJ-UHFFFAOYSA-N

InChI=1S/C12H9NO2/c1-14-11-8-4-2-3-5-10(8)13-12-9(11)6-7-15-12/h2-7H,1H3

HIDE SMILES / InChI

Molecular Formula	C12H9NO2
Molecular Weight	199.2054
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8999028 | https://www.ncbi.nlm.nih.gov/pubmed/7104872

Dictamnine, a furoquinoline alkaloid isolated from the root bark of Dictamnus dasycarpus Turcz. (Rutaceae) is reported to have a wide range of pharmacological activities. Dictamnine is a strong mutagen and phototoxic alkaloid with DNA as a cellular target.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
DNA 278 Target ID: DNA Sources: https://www.ncbi.nlm.nih.gov/pubmed/7104872	Binding Agent 1064

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
cis-Dihydrodiol, arene oxide and phenol metabolites of dictamnine: key intermediates in the biodegradation and biosynthesis of furoquinoline alkaloids.	2005 Aug 21	16075095
Identification of Ruta graveolens L. metabolites accumulated in the presence of abiotic elicitors.	2008 Jan-Feb	18052337
Constituents of the root wood of Zanthoxylum wutaiense with antitubercular activity.	2008 Jul	18564877
[Effects of penetration enhancers on in vitro percutaneous absorption and amount retained in skin of paeonol, dictamnine, fraxinellone and glycyrrhetinic acid in Liangfu cream].	2009 Jul	19894505
Isolation of secondary metabolites from Hortia oreadica (Rutaceae) leaves through high-speed counter-current chromatography.	2009 May 8	19249788
[Simultaneous determination of three active compounds in root barks of Dictamnus dasycarpus by RP-HPLC].	2010 Jan	20394291

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:48:17 GMT 2023` Edited by `admin` on `Fri Dec 15 19:48:17 GMT 2023`
Record UNII	HQZ3798D0A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DICTAMNINE

Common Name

English

DICTAMNINE [MI]

Common Name

English

DICTAMINE

Common Name

English

4-METHOXYFURO(2,3-B)QUINOLINE

Systematic Name

English

Code System Code Type Description

PUBCHEM

68085