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Details

Stereochemistry ACHIRAL
Molecular Formula C12H9NO2
Molecular Weight 199.2054
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DICTAMNINE

SMILES

COC1=C2C=CC=CC2=NC3=C1C=CO3

InChI

InChIKey=WIONIXOBNMDJFJ-UHFFFAOYSA-N
InChI=1S/C12H9NO2/c1-14-11-8-4-2-3-5-10(8)13-12-9(11)6-7-15-12/h2-7H,1H3

HIDE SMILES / InChI

Molecular Formula C12H9NO2
Molecular Weight 199.2054
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Dictamnine, a furoquinoline alkaloid isolated from the root bark of Dictamnus dasycarpus Turcz. (Rutaceae) is reported to have a wide range of pharmacological activities. Dictamnine is a strong mutagen and phototoxic alkaloid with DNA as a cellular target.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
[Dermatopharmacokinetic studies of liangfu cream in mice skin].
2010-09
[Simultaneous determination of three active compounds in root barks of Dictamnus dasycarpus by RP-HPLC].
2010-01
[Effects of penetration enhancers on in vitro percutaneous absorption and amount retained in skin of paeonol, dictamnine, fraxinellone and glycyrrhetinic acid in Liangfu cream].
2009-07
Isolation of secondary metabolites from Hortia oreadica (Rutaceae) leaves through high-speed counter-current chromatography.
2009-05-08
Alkaloids from the roots of Zanthoxylum nitidum and their antiviral and antifungal effects.
2008-09
Global gene expression profile of Saccharomyces cerevisiae induced by dictamnine.
2008-09
Constituents of the root wood of Zanthoxylum wutaiense with antitubercular activity.
2008-07
Effective biotic elicitation of Ruta graveolens L. shoot cultures by lysates from Pectobacterium atrosepticum and Bacillus sp.
2008-03
Identification of Ruta graveolens L. metabolites accumulated in the presence of abiotic elicitors.
2007-12-07
A survey of Chinese herbal ingredients with liver protection activities.
2007-05-10
Solar simulator-induced phototoxicity of the furoquinoline alkaloid dictamnine compared to 8-methoxypsoralen and 5-methoxypsoralen.
2006-08
Pressurized liquid extraction followed by high-performance liquid chromatography for determination of seven active compounds in Cortex Dictamni.
2006-03-10
[Studies on chemical constituents in bark of dictamnus dasycarpus].
2005-11
cis-Dihydrodiol, arene oxide and phenol metabolites of dictamnine: key intermediates in the biodegradation and biosynthesis of furoquinoline alkaloids.
2005-08-21
Furoquinoline alkaloids from the southern African Rutaceae Teclea natalensis.
2005-03
A new prenylated arylnaphthalene lignan from Haplophyllum myrtifolium.
2003-09
Plants traditionally prescribed to treat tazo (malaria) in the eastern region of Madagascar.
2003-07-24
Isolation and in vitro antiplasmodial activities of alkaloids from Teclea trichocarpa: in vivo antimalarial activity and X-ray crystal structure of normelicopicine.
2002-07
Feeding deterrents from Dictamnus dasycarpus Turcz against two stored-product insects.
2002-03-13

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Curator's Comment: In vitro, labeled dictamnine was shown to form covalent monoadducts with purified DNA from M. hiemalis in the presence of long-wave ultraviolet light.
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 19:57:37 GMT 2025
Edited
by admin
on Mon Mar 31 19:57:37 GMT 2025
Record UNII
HQZ3798D0A
Record Status Validated (UNII)
Record Version
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Name Type Language
DICTAMNINE
MI  
Common Name English
DICTAMINE
Preferred Name English
DICTAMNINE [MI]
Common Name English
4-METHOXYFURO(2,3-B)QUINOLINE
Systematic Name English
Code System Code Type Description
PUBCHEM
68085
Created by admin on Mon Mar 31 19:57:37 GMT 2025 , Edited by admin on Mon Mar 31 19:57:37 GMT 2025
PRIMARY
CAS
484-29-7
Created by admin on Mon Mar 31 19:57:37 GMT 2025 , Edited by admin on Mon Mar 31 19:57:37 GMT 2025
PRIMARY
FDA UNII
HQZ3798D0A
Created by admin on Mon Mar 31 19:57:37 GMT 2025 , Edited by admin on Mon Mar 31 19:57:37 GMT 2025
PRIMARY
MERCK INDEX
m4369
Created by admin on Mon Mar 31 19:57:37 GMT 2025 , Edited by admin on Mon Mar 31 19:57:37 GMT 2025
PRIMARY Merck Index
EPA CompTox
DTXSID0041012
Created by admin on Mon Mar 31 19:57:37 GMT 2025 , Edited by admin on Mon Mar 31 19:57:37 GMT 2025
PRIMARY
DAILYMED
HQZ3798D0A
Created by admin on Mon Mar 31 19:57:37 GMT 2025 , Edited by admin on Mon Mar 31 19:57:37 GMT 2025
PRIMARY