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Details

Stereochemistry ACHIRAL
Molecular Formula CHO3
Molecular Weight 61.0169
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge -1

SHOW SMILES / InChI
Structure of BICARBONATE ION

SMILES

C(=O)(O)[O-]

InChI

InChIKey=BVKZGUZCCUSVTD-UHFFFAOYSA-M
InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1

HIDE SMILES / InChI

Description
Curator's Comment:: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/26617001 | https://www.ncbi.nlm.nih.gov/pubmed/3449184 | https://www.ncbi.nlm.nih.gov/pubmed/3449184 | https://www.ncbi.nlm.nih.gov/pubmed/16864561

Diammonium carbonate is a salt with the chemical formula (NH4)2CO3. Since it readily degrades to gaseous ammonia and carbon dioxide upon heating, it is used as a leavening agent and also as smelling salt. Ammonium carbonate may be used as a leavening agent in traditional recipes, particularly those from northern Europe and Scandinavia (e.g. Speculoos, Tunnbröd or Lebkuchen). It also serves as an acidity regulator and has the E number E503. Ammonium carbonate is the main component of smelling salts, although the commercial scale of their production is small. Buckley's cough syrup from Canada today uses ammonium carbonate as an active ingredient intended to help relieve symptoms of bronchitis. Ammonium carbonate is also used as an emetic.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
85.0 mM [Ki]
12.0 mM [Ki]
95.0 mM [Ki]
0.27 mM [Ki]
0.086 mM [Ki]
0.8 mM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
SODIUM BICARBONATE

Approved Use

INDICATIONS AND USAGE. Sodium Bicarbonate Injection, USP is indicated in the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Sodium bicarbonate is further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturate-protein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of hemoglobin and its breakdown products. Sodium bicarbonate also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate.

Launch Date

1.12639685E12
Curative
SODIUM BICARBONATE

Approved Use

INDICATIONS AND USAGE. Sodium Bicarbonate Injection, USP is indicated in the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Sodium bicarbonate is further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturate-protein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of hemoglobin and its breakdown products. Sodium bicarbonate also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate.

Launch Date

1.12639685E12
Primary
SODIUM BICARBONATE

Approved Use

INDICATIONS AND USAGE. Sodium Bicarbonate Injection, USP is indicated in the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Sodium bicarbonate is further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturate-protein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of hemoglobin and its breakdown products. Sodium bicarbonate also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate.

Launch Date

1.12639685E12
PubMed

PubMed

TitleDatePubMed
Toxic synergism of disopyramide and hyperkalemia.
1980 Oct
Dose-response effects of atropine on pancreatic secretory response to intravenous cerulein in dogs.
1986
Proximal renal tubular acidosis secondary to FK506 in pediatric liver transplant patients.
1995 Aug
Bicarbonate reabsorption and NHE-3 expression: abundance and activity are increased in Henle's loop of remnant rats.
2002 Dec
Anion exchanger isoform 2 operates in parallel with Na(+)/H(+) exchanger isoform 1 during regulatory volume decrease of human cervical cancer cells.
2002 Feb 13
[Metformin-associated lactic acidosis with acute renal failure in type 2 diabetes mellitus].
2002 Feb 15
Correction of CFTR malfunction and stimulation of Ca-activated Cl channels restore HCO3- secretion in cystic fibrosis bile ductular cells.
2002 Jan
An alternative mechanism of bicarbonate-mediated peroxidation by copper-zinc superoxide dismutase: rates enhanced via proposed enzyme-associated peroxycarbonate intermediate.
2003 Jun 6
Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes.
2003 Mar
HCO(3)(-)-dependent soluble adenylyl cyclase activates cystic fibrosis transmembrane conductance regulator in corneal endothelium.
2003 May
Acute regulation of the SLC26A3 congenital chloride diarrhoea anion exchanger (DRA) expressed in Xenopus oocytes.
2003 May 15
[HCO3-]-regulated expression and activity of soluble adenylyl cyclase in corneal endothelial and Calu-3 cells.
2004 Apr 29
NHE3 inhibition activates duodenal bicarbonate secretion in the rat.
2004 Jan
Inhibitory regulation of cystic fibrosis transmembrane conductance regulator anion-transporting activities by Shank2.
2004 Mar 12
Cystic fibrosis gene mutation reduces epithelial cell acidification and injury in acid-perfused mouse duodenum.
2004 Oct
Novel regulation of cystic fibrosis transmembrane conductance regulator (CFTR) channel gating by external chloride.
2004 Oct 1
Endothelin-3 applied to the brain evokes opposite effects on bile secretion mediated by a central nitric oxide pathway.
2005 Jul
Effect of bicarbonate on iron-mediated oxidation of low-density lipoprotein.
2005 Jul 26
Chloride conductance of CFTR facilitates basal Cl-/HCO3- exchange in the villous epithelium of intact murine duodenum.
2005 Jun
ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties.
2006 Jul
Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.
2007 Dec 1
DNA cleavage mediated by copper superoxide dismutase via two pathways.
2007 Feb
Gender-specific protection of estrogen against gastric acid-induced duodenal injury: stimulation of duodenal mucosal bicarbonate secretion.
2008 Sep
How to explain a PaO2 of 140 mmHg in a venous line?
2009
Peroxymonocarbonate and carbonate radical displace the hydroxyl-like oxidant in the Sod1 peroxidase activity under physiological conditions.
2009 Apr
Does glucose infusion exacerbate metformin-associated lactate acidosis? A case report.
2009 Jul
Patents

Sample Use Guides

In cardiac arrest, a rapid intravenous dose of one to two 50 mL syringes (44.6 to 100 mEq) may be given initially and continued at a rate of 50 mL (44.6 to 50 mEq) every 5 to 10 minutes if necessary (as indicated by arterial pH and blood gas monitoring) to reverse the acidosis. Caution should be observed in emergencies where very rapid infusion of large quantities of bicarbonate is indicated. Bicarbonate solutions are hypertonic and may produce an undesirable rise in plasma sodium concentration in the process of correcting the metabolic acidosis. In cardiac arrest, however, the risks from acidosis exceed those of hypernatremia. In less urgent forms of metabolic acidosis. Sodium Bicarbonate Injection, USP may be added to other intravenous fluids. The amount of bicarbonate to be given to older children and adults over a four-to- eight-hour period is approximately 2 to 5 mEq/kg of body weight - depending upon the severity of the acidosis as judged by the lowering of total CO2 content blood pH and clinical condition of the patient In metabolic acidosis associated with shock, therapy should be monitored by measuring blood gases, plasma osmolar'rty, arterial blood lactate, hemodynamics and cardiac rhythm. Bicarbonate therapy should always be planned in a stepwise fashion since the degree of response from a given dose is not precisely predictable. Initially an infusion of 2 to 5 mEq/kg body weight over a period of 4 to 8 hours will produce a measurable improvement in the abnormal acid- base status of the blood. The next step of therapy is dependent upon the clinical response of the patient. If severe symptoms have abated, then the frequency of administration and the size of the dose may be reduced.
Route of Administration: Intravenous
A. thaliana var. Landsberg erecta (LER) suspension cells were treated with NaHCO3 at a final concentration of 1, 3, or 10 mM. For controls, NaNO3 (NO3 − is a macronutrient in MS media) was added in same concentration to nullify the effect of Na+ during the treatment. Furthermore, as HCO3 − induced significant pH changes of the MS media (pH 5.8), we added 50 mM (for 1 mM and 3 mM HCO3 −) and 100 mM (for 10 mM HCO3 −) MES buffer (pH 5.8) to the MS media, and the pH-stabilized MS media were used for both control and HCO3− treatments. In addition, the buffered MS media were sonicated to remove atmospheric gases prior to addition of HCO3−. Cells were incubated at 25 °C for 0, 5, 15, 30, 60, and 120 min on a shaker, and four replicates (n = 4) were generated for each data point after treatment with HCO3 − (treatment) and control. After treatment, 100 ml cells at a concentration of 3 x 10^6 ml−1 were filtered using filter paper mounted on funnels, quickly blotted dry using Kim wipes and immediately snap-frozen in liquid nitrogen and stored in a − 80 °C freezer until metabolite extraction.
Name Type Language
BICARBONATE ION
Common Name English
BICARBONATE
MART.   VANDF  
Systematic Name English
MONOHYDROGEN CARBONATE
Systematic Name English
BICARBONATE [MART.]
Common Name English
CARBONATE, HYDROGEN
Systematic Name English
HYDROGEN CARBONATE
Systematic Name English
BICARBONATE [VANDF]
Common Name English
Classification Tree Code System Code
LOINC 16459-0
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LOINC 28640-1
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LOINC 80613-3
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LOINC 47580-6
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LOINC 16461-6
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LOINC 16460-8
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FDA ORPHAN DRUG 276609
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LOINC 19229-4
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LOINC 22735-5
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LOINC 1960-4
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LOINC 54361-1
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CFR 21 CFR 862.1160
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LOINC 1962-0
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LOINC 12513-8
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LOINC 28641-9
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LOINC 54360-3
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LOINC 47579-8
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LOINC 16462-4
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CFR 21 CFR 331.11
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LOINC 1964-6
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LOINC 53086-5
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NCI_THESAURUS C597
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LOINC 14627-4
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LOINC 12514-6
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LOINC 14151-5
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LOINC 1959-6
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LOINC 1961-2
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CFR 21 CFR 331.15
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FDA ORPHAN DRUG 198904
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LOINC 1963-8
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Code System Code Type Description
EPA CompTox
71-52-3
Created by admin on Sat Jun 26 15:20:38 UTC 2021 , Edited by admin on Sat Jun 26 15:20:38 UTC 2021
PRIMARY
PUBCHEM
769
Created by admin on Sat Jun 26 15:20:38 UTC 2021 , Edited by admin on Sat Jun 26 15:20:38 UTC 2021
PRIMARY
WIKIPEDIA
BICARBONATE
Created by admin on Sat Jun 26 15:20:38 UTC 2021 , Edited by admin on Sat Jun 26 15:20:38 UTC 2021
PRIMARY
RXCUI
1546277
Created by admin on Sat Jun 26 15:20:38 UTC 2021 , Edited by admin on Sat Jun 26 15:20:38 UTC 2021
PRIMARY RxNorm
NCI_THESAURUS
C37918
Created by admin on Sat Jun 26 15:20:38 UTC 2021 , Edited by admin on Sat Jun 26 15:20:38 UTC 2021
PRIMARY
CAS
71-52-3
Created by admin on Sat Jun 26 15:20:38 UTC 2021 , Edited by admin on Sat Jun 26 15:20:38 UTC 2021
PRIMARY
EVMPD
SUB37053
Created by admin on Sat Jun 26 15:20:38 UTC 2021 , Edited by admin on Sat Jun 26 15:20:38 UTC 2021
PRIMARY
FDA UNII
HN1ZRA3Q20
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PRIMARY