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Details

Stereochemistry ACHIRAL
Molecular Formula C7H7NO2.C4H11N
Molecular Weight 210.2728
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIETHYLAMMONIUM P-AMINOBENZOATE

SMILES

CCNCC.NC1=CC=C(C=C1)C(O)=O

InChI

InChIKey=XMYMCNNZVQZVJW-UHFFFAOYSA-N
InChI=1S/C7H7NO2.C4H11N/c8-6-3-1-5(2-4-6)7(9)10;1-3-5-4-2/h1-4H,8H2,(H,9,10);5H,3-4H2,1-2H3

HIDE SMILES / InChI

Description
Sources: Bollettino - Societa Italiana di Biologia Sperimentale, Volume 27, Pages275-6, Journal, 1951
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/14883411 | https://www.ncbi.nlm.nih.gov/pubmed/14391554 | https://www.ncbi.nlm.nih.gov/pubmed/14858664

Diethylammonium p-aminobenzoate is a powerful heart stimulant, with considerable effect on the uterus. Diethylammonium p-aminobenzoate protected the heart from the poisoning caused by procaine, maxicaine or xylocaine, and also against high doses of procaine amide. The substance passes the blood-spinal fluid barrier but high doses are necessary to find it in the spinal fluid, where it appears later than in the other body fluids. Diethylammonium p-aminobenzoate reduces the spontaneous activity of mice.

CNS Activity

CNS Penetrant
2554
Sources: Archivio per le Scienze Mediche, Volume 95, Pages 413-20, Journal, 1953

Originator

Mainardi, L.|Semenza, F.
1
Sources: Bollettino - Societa Italiana di Biologia Sperimentale Volume 27, Pages 275-6, Journal, 1951

Approval Year

Unknown
139594
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Not Provided
504
Unknown

Approved Use

Glimepiride tablets are indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus [see Clinical Studies ( 14.1)
PubMed

PubMed

TitleDatePubMed
Patents

Patents

GB695585
1

Sample Use Guides

In Vivo Use Guide
Sources: Bollettino - Societa Italiana di Biologia Sperimentale, Volume 27, Pages275-6, Journal, 1951
Chronic toxicity tests showed no mortality in rats by oral administration of 0.250 g/kg. per day for 60 days, but a slight loss in wt. was noted
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
DIETHYLAMMONIUM P-AMINOBENZOATE
Common Name English
AMINOBENZOIC ACID DIETHYLAMINE SALT
Common Name English
BENZOIC ACID, 4-AMINO-, COMPD. WITH N-ETHYLETHANAMINE (1:1)
Common Name English
P-AMINOBENZOIC ACID DIETHYLAMINE SALT [MI]
Common Name English
NEVANIDE
Brand Name English
P-AMINOBENZOIC ACID DIETHYLAMINE SALT
MI  
Common Name English
Code System Code Type Description
MERCK INDEX
m1688
Created by admin on Sat Dec 16 10:59:00 GMT 2023 , Edited by admin on Sat Dec 16 10:59:00 GMT 2023
PRIMARY Merck Index
CAS
6018-84-4
Created by admin on Sat Dec 16 10:59:00 GMT 2023 , Edited by admin on Sat Dec 16 10:59:00 GMT 2023
PRIMARY
FDA UNII
HM0PW39IN5
Created by admin on Sat Dec 16 10:59:00 GMT 2023 , Edited by admin on Sat Dec 16 10:59:00 GMT 2023
PRIMARY
PUBCHEM
22369
Created by admin on Sat Dec 16 10:59:00 GMT 2023 , Edited by admin on Sat Dec 16 10:59:00 GMT 2023
PRIMARY
NIH
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