Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H10O2 |
| Molecular Weight | 138.1638 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OCCOC1=CC=CC=C1
InChI
InChIKey=QCDWFXQBSFUVSP-UHFFFAOYSA-N
InChI=1S/C8H10O2/c9-6-7-10-8-4-2-1-3-5-8/h1-5,9H,6-7H2
DescriptionCurator's Comment: Description was created based on several sources, including
https://www.ewg.org/skindeep/ingredient/704811/PHENOXYETHANOL/ and http://www.kliinikum.ee/haiglaapteek/attachments/article/51/Octenisept%20(ENG).pdf
Curator's Comment: Description was created based on several sources, including
https://www.ewg.org/skindeep/ingredient/704811/PHENOXYETHANOL/ and http://www.kliinikum.ee/haiglaapteek/attachments/article/51/Octenisept%20(ENG).pdf
Phenoxyethanol, also known as Ethylene Glycol Monophenyl Ether, is a glycol ether and bactericide (that functions as a disinfectant, antiseptic or antibiotic) that is primarily used as a preservative in cosmetics and beauty products. It is used as a preservative in vaccines. Phenoxyethanol is included in topical antiseptic solutions, like octenisept used for the treatment of traumatic, acute, chronic, surgical and burn wounds, the treatment of bacterial vaginosis, acne lesions and as the mucous membrane antiseptic.
CNS Activity
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL4794 |
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Target ID: Pseudomonas aeruginosa growth |
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Target ID: Staphylococcus aureus growth |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Curative | Octenisept Approved UseApplication areas:
Wound treatment
Antiseptic treatment of traumatic, acute, chronic, surgical and burn wounds.
Mocous membrane antiseptic
• prior to diagnostic and surgical interventions in the anogenital (e.g. before obliteration of haemorrids), the urogenital area (e.g. before placing an intra-uterine device (IUD), the vaginal area, before prenatal, intranatal and postnatal manipulations) and in the oral cavity (e.g. before tooth extractions)
• before placing urinary tract catheters
• for preop. skin antisepsis in the area close to mucous membranes
MRSA
• for antimicrobial whole body wash with MRSA colonised patients |
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| Curative | Octenisept Approved UseApplication areas:
Wound treatment
Antiseptic treatment of traumatic, acute, chronic, surgical and burn wounds.
Mocous membrane antiseptic
• prior to diagnostic and surgical interventions in the anogenital (e.g. before obliteration of haemorrids), the urogenital area (e.g. before placing an intra-uterine device (IUD), the vaginal area, before prenatal, intranatal and postnatal manipulations) and in the oral cavity (e.g. before tooth extractions)
• before placing urinary tract catheters
• for preop. skin antisepsis in the area close to mucous membranes
MRSA
• for antimicrobial whole body wash with MRSA colonised patients |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Influence of anatomical site and topical formulation on skin penetration of sunscreens. | 2005 Sep |
|
| ICI 182,780 has agonistic effects and synergizes with estradiol-17 beta in fish liver, but not in testis. | 2006 Dec 27 |
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| Intraperitoneal octenidindihydro-chloride - phenoxyethanol solution to prevent peritoneal adhesion formation in a rat peritonitis model. | 2007 |
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| Some observations on the diffusion of antimicrobial agents through the retention balloons of foley catheters. | 2007 Aug |
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| Preparation and solution behavior of a thermoresponsive diblock copolymer of poly(ethyl glycidyl ether) and poly(ethylene oxide). | 2007 Aug 28 |
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| Antimicrobial preservative use in parenteral products: past and present. | 2007 Dec |
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| Role of (3Z,6Z,8E)-dodecatrien-1-ol in trail following, feeding, and mating behavior of Reticulitermes hesperus. | 2007 Feb |
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| Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution. | 2007 Jun 28 |
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| [Effect of 2-phenoxyethanol on potency of Sabin inactivated poliomyelitis vaccine and its safety]. | 2007 Mar |
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| Comparison of objective and sensory skin irritations of several cosmetic preservatives. | 2007 Mar |
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| Developmental expression of DAX1 in the European sea bass, Dicentrarchus labrax: lack of evidence for sexual dimorphism during sex differentiation. | 2007 May 30 |
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| Dynamic gene expression in fish muscle during recovery growth induced by a fasting-refeeding schedule. | 2007 Nov 28 |
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| The impact of meteorological conditions on patch test results with 12 standard series allergens (fragrances, biocides, topical ingredients). | 2008 Apr |
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| The fate of the duplicated androgen receptor in fishes: a late neofunctionalization event? | 2008 Dec 18 |
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| Effect of Octenisept antiseptic on bioburden of neoplastic ulcers in patients with advanced cancer. | 2008 Jan |
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| A simple and rapid method for quantifying 2-phenoxyethanol (2-PE) in Diphtheria, Tetanus and w-Pertussis (DTwP) vaccine. | 2008 Jan |
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| Skin protection creams in medical settings: successful or evil? | 2008 Jul 25 |
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| Selective gray matter staining of human brain slices: optimized use of cadaver materials. | 2008 Jun |
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| Contact hypersensitivity to selected excipients of dermatological topical preparations and cosmetics in patients with chronic eczema. | 2008 Jun |
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| The Tg(ccnb1:EGFP) transgenic zebrafish line labels proliferating cells during retinal development and regeneration. | 2008 May 19 |
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| Plasma 11-deoxycorticosterone (DOC) and mineralocorticoid receptor testicular expression during rainbow trout Oncorhynchus mykiss spermiation: implication with 17alpha, 20beta-dihydroxyprogesterone on the milt fluidity? | 2008 May 19 |
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| Development of an SPME-GC-MS/MS procedure for the monitoring of 2-phenoxyethanol in anaesthetised fish. | 2008 May 30 |
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| Determination of household chemicals using gas chromatography and liquid chromatography with tandem mass spectrometry. | 2008 May 9 |
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| Comparison of acute toxicity of 2-phenoxyethanol and clove oil to juvenile and embryonic stages of Danio rerio. | 2008 Oct |
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| Simultaneous determination of 21 preservatives in cosmetics by ultra performance liquid chromatography. | 2008 Oct |
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| In silico identification and molecular characterization of genes predominantly expressed in the fish oocyte. | 2008 Oct 23 |
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| Changes induced by dietary energy intake and divergent selection for muscle fat content in rainbow trout (Oncorhynchus mykiss), assessed by transcriptome and proteome analysis of the liver. | 2008 Oct 29 |
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| Genomic resources for a commercial flatfish, the Senegalese sole (Solea senegalensis): EST sequencing, oligo microarray design, and development of the Soleamold bioinformatic platform. | 2008 Oct 30 |
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| [Simultaneous determination of adapalene, 2-phenoxyethanol and methyl-4-hydroxybenzoate in adapalene gels using high performance liquid chromatography]. | 2008 Sep |
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| 2-Phenoxyethanol as anaesthetic in removing relocating 102 species of fishes representing from Sea World to uShaka Marine World, South Africa. | 2008 Sep |
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| Efficacy of octenidine dihydrochloride and 2-phenoxyethanol in the topical treatment of inflammatory acne. | 2008 Sep |
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| Determination of quantitative trait loci (QTL) for early maturation in rainbow trout (Oncorhynchus mykiss). | 2008 Sep-Oct |
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| [Contact sensitization to Euxyl K-400]. | 2009 Apr |
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| Two new phenylglycol derivatives isolated from Syringa reticulata var. mandshurica and their antifungal activities. | 2009 Aug |
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| Minimal change nephrotic syndrome in an 82 year old patient following a tetanus-diphteria-poliomyelitis-vaccination. | 2009 Aug 5 |
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| A large new subset of TRIM genes highly diversified by duplication and positive selection in teleost fish. | 2009 Feb 5 |
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| Contact urticaria due to phenoxyethanol in an aftershave. | 2009 Jul-Aug |
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| Contact dermatitis due to use of Octenisept in wound care. | 2009 Sep |
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| Differential expression of the heat shock protein Hsp70 in natural populations of the tilapia, Sarotherodon melanotheron, acclimatised to a range of environmental salinities. | 2010 Apr 29 |
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| The effect of a combination of 0.1% octenidine dihydrochloride and 2% 2-phenoxyethanol (octenisept) on wound healing in pigs in vivo and its in vitro percutaneous permeation through intact and barrier disrupted porcine skin. | 2010 Feb |
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| Consumer exposure to biocides--identification of relevant sources and evaluation of possible health effects. | 2010 Feb 3 |
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| Comparative transcriptomic analysis of follicle-enclosed oocyte maturational and developmental competence acquisition in two non-mammalian vertebrates. | 2010 Jan 8 |
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| The impact of ethylene glycol monomethyl ether on ovarian function may extend to the next generation in female mice: a preliminary study. | 2010 Jul |
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| Comparison of local metronidazole and a local antiseptic in the treatment of bacterial vaginosis. | 2010 Jul |
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| Aerobic oxidation of lignin models using a base metal vanadium catalyst. | 2010 Jun 21 |
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| The relative toxicity of compounds used as preservatives in vaccines and biologics. | 2010 May |
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| Monitoring stress in fish by applying image analysis to their skin mucous cells. | 2010 May 10 |
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| The production of fluorescent transgenic trout to study in vitro myogenic cell differentiation. | 2010 May 17 |
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| Bisphenol A in oocytes leads to growth suppression and altered stress performance in juvenile rainbow trout. | 2010 May 20 |
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| Ocular symptoms, tear film stability, nasal patency, and biomarkers in nasal lavage in indoor painters in relation to emissions from water-based paint. | 2010 Oct |
Patents
Sample Use Guides
100g of octenisept solution contains: Octenidine dihydrochloride 0.1g, 2-Phenoxyethanol (Ph.Eur.) 2.0g
Moisturize the treated area evenly and thoroughly with the antiseptic.
• Swab method: Rub concerned areas with saturated swabs.
Swabbing is the prefered method of application.
• Spray method: In individual cases spray octenisept® directly on poorly accessible areas of the skin and mucous membrane. Make sure all areas are evenly moistened.
Route of Administration:
Topical
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NCI_THESAURUS |
C28394
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C005398
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HIE492ZZ3T
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PHENOXYETHANOL
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ACTIVE MOIETY
