Details
Stereochemistry | ACHIRAL |
Molecular Formula | C22H24N2O4 |
Molecular Weight | 380.437 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 2 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC1=CC=C(C=C1)\C=C\C(=O)NCCCCNC(=O)\C=C\C2=CC=C(O)C=C2
InChI
InChIKey=PYVBFDCHJDMSMM-FNCQTZNRSA-N
InChI=1S/C22H24N2O4/c25-19-9-3-17(4-10-19)7-13-21(27)23-15-1-2-16-24-22(28)14-8-18-5-11-20(26)12-6-18/h3-14,25-26H,1-2,15-16H2,(H,23,27)(H,24,28)/b13-7+,14-8+
BIS-COUMARAMIDOBUTANE was isolated and purified from corn bran. It exhibited the strongest hydroxyl radical scavenging activity. The inhibitory effects of BIS-COUMARAMIDOBUTANE on melanogenesis is due to the inhibition of the intracellular tyrosinase activity. This indicate that BIS-COUMARAMIDOBUTANE from corn bran may be potential natural skin whitening agents. BIS-COUMARAMIDOBUTANE is registrated in International Cosmetic Ingredient Dictionary in Korea.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL3318 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17397179 |
181.7 µM [IC50] | ||
Target ID: WP408 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17397179 |
120.55 µM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17397179
The BIS-COUMARAMIDOBUTANE exhibited considerable inhibitory activity (IC(50 )=3169.45 uM) on melanin synthesis of cultured B16 melanoma cell.
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DTXSID70189932
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44241258
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364048-94-2
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HFN1DLN96K
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admin on Sat Dec 16 00:46:12 GMT 2023 , Edited by admin on Sat Dec 16 00:46:12 GMT 2023
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SUBSTANCE RECORD