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Details

Stereochemistry ACHIRAL
Molecular Formula C22H24N2O4
Molecular Weight 380.437
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 2
Charge 0

SHOW SMILES / InChI
Structure of BIS-COUMARAMIDOBUTANE

SMILES

OC1=CC=C(C=C1)\C=C\C(=O)NCCCCNC(=O)\C=C\C2=CC=C(O)C=C2

InChI

InChIKey=PYVBFDCHJDMSMM-FNCQTZNRSA-N
InChI=1S/C22H24N2O4/c25-19-9-3-17(4-10-19)7-13-21(27)23-15-1-2-16-24-22(28)14-8-18-5-11-20(26)12-6-18/h3-14,25-26H,1-2,15-16H2,(H,23,27)(H,24,28)/b13-7+,14-8+

HIDE SMILES / InChI
BIS-COUMARAMIDOBUTANE was isolated and purified from corn bran. It exhibited the strongest hydroxyl radical scavenging activity. The inhibitory effects of BIS-COUMARAMIDOBUTANE on melanogenesis is due to the inhibition of the intracellular tyrosinase activity. This indicate that BIS-COUMARAMIDOBUTANE from corn bran may be potential natural skin whitening agents. BIS-COUMARAMIDOBUTANE is registrated in International Cosmetic Ingredient Dictionary in Korea.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
181.7 µM [IC50]
120.55 µM [IC50]
Conditions
PubMed

PubMed

TitleDatePubMed
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
The BIS-COUMARAMIDOBUTANE exhibited considerable inhibitory activity (IC(50 )=3169.45 uM) on melanin synthesis of cultured B16 melanoma cell.
Name Type Language
BIS-COUMARAMIDOBUTANE
INCI  
INCI  
Official Name English
2-PROPENAMIDE, N,N'-1,4-BUTANEDIYLBIS(3-(4-HYDROXYPHENYL)-, (2E,2'E)-
Common Name English
BIS-COUMARAMIDOBUTANE [INCI]
Common Name English
N,N'-DICOUMAROYLPUTRESCINE
Common Name English
SID CORN DCP
Brand Name English
Code System Code Type Description
EPA CompTox
DTXSID70189932
Created by admin on Sat Dec 16 00:46:12 GMT 2023 , Edited by admin on Sat Dec 16 00:46:12 GMT 2023
PRIMARY
PUBCHEM
44241258
Created by admin on Sat Dec 16 00:46:12 GMT 2023 , Edited by admin on Sat Dec 16 00:46:12 GMT 2023
PRIMARY
CAS
364048-94-2
Created by admin on Sat Dec 16 00:46:12 GMT 2023 , Edited by admin on Sat Dec 16 00:46:12 GMT 2023
PRIMARY
FDA UNII
HFN1DLN96K
Created by admin on Sat Dec 16 00:46:12 GMT 2023 , Edited by admin on Sat Dec 16 00:46:12 GMT 2023
PRIMARY