FLUMETHASONE 21-ACETATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H30F2O6
Molecular Weight	452.4882
Optical Activity	UNSPECIFIED
Defined Stereocenters	9 / 9
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COC(C)=O

InChI

InChIKey=ISSQQUKLQJHHOR-OSNGSNEUSA-N

InChI=1S/C24H30F2O6/c1-12-7-15-16-9-18(25)17-8-14(28)5-6-21(17,3)23(16,26)19(29)10-22(15,4)24(12,31)20(30)11-32-13(2)27/h5-6,8,12,15-16,18-19,29,31H,7,9-11H2,1-4H3/t12-,15+,16+,18+,19+,21+,22+,23+,24+/m1/s1

HIDE SMILES / InChI

Description
Sources: doi: 10.1016/B978-1-4832-3034-4.50012-0
Curator's Comment: description was created based on several sources, including: DOI: 10.1021/ja01494a054 | https://www.ncbi.nlm.nih.gov/pubmed/4102842

Flumethasone 21-acetate is an anti-inflammatory corticosteroid. It has 300 times greater anti-inflammatory activity and 677 times greater capacity to promote liver glycogen deposition than hydrocortisone. It has anti-rheumatic potency 31 times higher than cortisol.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Anaphylaxis 47 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4102842	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Rm values of steroids as an expression of their lipophilic character in structure-activity studies.	1975-09	1159709
Versatile system for partition chromatography of corticosteroids and prediction of their elution curves.	1972-05	5035775
Hypersensitivity in mice. II. The effect of chemical compounds on systemic active anaphylaxis and on anaphylaxis-like reactions in normal and B. pertussis-pretreated mice.	1971	4102842

Patents

Sample Use Guides

In Vivo Use Guide

Median effective dose (ED50) 0.1 mg/kg/day. Two injections 48 and 24 h prior to challenge.

Route of Administration: Other

In Vitro Use Guide

Unknown

Name

Type

Language

FLUMETHASONE 21-ACETATE

Common Name

English

FLUMETASONE ACETATE

Preferred Name

English

FLUMETHASONE ACETATE [GREEN BOOK]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C521