FLUMETHASONE 21-ACETATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H30F2O6
Molecular Weight	452.4882
Optical Activity	UNSPECIFIED
Defined Stereocenters	9 / 9
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12C[C@@H](C)[C@](O)(C(=O)COC(C)=O)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])C[C@H](F)C4=CC(=O)C=C[C@]34C

InChI

InChIKey=ISSQQUKLQJHHOR-OSNGSNEUSA-N

InChI=1S/C24H30F2O6/c1-12-7-15-16-9-18(25)17-8-14(28)5-6-21(17,3)23(16,26)19(29)10-22(15,4)24(12,31)20(30)11-32-13(2)27/h5-6,8,12,15-16,18-19,29,31H,7,9-11H2,1-4H3/t12-,15+,16+,18+,19+,21+,22+,23+,24+/m1/s1

HIDE SMILES / InChI

Description
Sources: doi: 10.1016/B978-1-4832-3034-4.50012-0
Curator's Comment: description was created based on several sources, including: DOI: 10.1021/ja01494a054 | https://www.ncbi.nlm.nih.gov/pubmed/4102842

Flumethasone 21-acetate is an anti-inflammatory corticosteroid. It has 300 times greater anti-inflammatory activity and 677 times greater capacity to promote liver glycogen deposition than hydrocortisone. It has anti-rheumatic potency 31 times higher than cortisol.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Anaphylaxis 46 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4102842	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Hypersensitivity in mice. II. The effect of chemical compounds on systemic active anaphylaxis and on anaphylaxis-like reactions in normal and B. pertussis-pretreated mice.	1971	4102842
Versatile system for partition chromatography of corticosteroids and prediction of their elution curves.	1972 May	5035775
Rm values of steroids as an expression of their lipophilic character in structure-activity studies.	1975 Sep	1159709

Patents

Sample Use Guides

In Vivo Use Guide

Median effective dose (ED50) 0.1 mg/kg/day. Two injections 48 and 24 h prior to challenge.

Route of Administration: Other

In Vitro Use Guide

Unknown

Name

Type

Language

FLUMETHASONE 21-ACETATE

Common Name

English

FLUMETASONE ACETATE

Common Name

English

FLUMETHASONE ACETATE [GREEN BOOK]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C521