Details
Stereochemistry | RACEMIC |
Molecular Formula | C17H14O3S |
Molecular Weight | 298.356 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C(O)=O)C1=CC2=C(SC3=C(C=CC=C3)C(=O)C2)C=C1
InChI
InChIKey=MUXFZBHBYYYLTH-UHFFFAOYSA-N
InChI=1S/C17H14O3S/c1-10(17(19)20)11-6-7-15-12(8-11)9-14(18)13-4-2-3-5-16(13)21-15/h2-8,10H,9H2,1H3,(H,19,20)
DescriptionSources: http://www.ncbi.nlm.nih.gov/pubmed/12065695Curator's Comment: description was created based on several sources, including, http://www.ncbi.nlm.nih.gov/pubmed/16473424
Sources: http://www.ncbi.nlm.nih.gov/pubmed/12065695
Curator's Comment: description was created based on several sources, including, http://www.ncbi.nlm.nih.gov/pubmed/16473424
Zaltoprofen is a non-steroidal anti-inflammatory drug approved in Japan for the treatment of lumbar pain, frozen shoulder, osteoarthritis, musculoskeletal pain, dental pain, post-operative pain. The main mechanism of action involves the inhibition of COX-2. Additional mechanism may be associated with the inhibitory effect of zaltoprofen on bradykinin-induced nociceptive responses that happens without blocking bradykinin receptors.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: P35354 Gene ID: 5743.0 Gene Symbol: PTGS2 Target Organism: Homo sapiens (Human) Sources: www.ncbi.nlm.nih.gov/pubmed/12065695 |
0.34 nM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Palliative | SOLETON Approved UseIt is usually used for anti-inflammation and analgesia in rheumatoid arthritis, osteoarthritis, low back pain, shoulder periarthritis, cervicobrachial syndrome as well as pain after operation, injuries or tooth removal. |
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Palliative | SOLETON Approved UseIt is usually used for anti-inflammation and analgesia in rheumatoid arthritis, osteoarthritis, low back pain, shoulder periarthritis, cervicobrachial syndrome as well as pain after operation, injuries or tooth removal. |
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Palliative | SOLETON Approved UseIt is usually used for anti-inflammation and analgesia in rheumatoid arthritis, osteoarthritis, low back pain, shoulder periarthritis, cervicobrachial syndrome as well as pain after operation, injuries or tooth removal. |
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Palliative | SOLETON Approved UseIt is usually used for anti-inflammation and analgesia in rheumatoid arthritis, osteoarthritis, low back pain, shoulder periarthritis, cervicobrachial syndrome as well as pain after operation, injuries or tooth removal. |
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Primary | SOLETON Approved UseIt is usually used for anti-inflammation and analgesia in rheumatoid arthritis, osteoarthritis, low back pain, shoulder periarthritis, cervicobrachial syndrome as well as pain after operation, injuries or tooth removal. |
Sample Use Guides
In general, for adults, take 1 tablet (80 mg of the active ingredient) at a time, 3 times a day. If the medicine is taken as needed, take 1 to 2 tablets (80 mg to 160 mg) at a time.
Route of Administration:
Oral
The proliferation of rheumatoid synovial cells was studied after incubation with zaltoprofen (300 uM). IC50 value for inhibition of cell viability was 135.2 uM. Zaltoprofen suppressedthecellproliferationin a concentration-dependent manner, with IC50 value of 48.9 uM.
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NCI_THESAURUS |
C257
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H8635NG3PY
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Zaltoprofen
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CHEMBL1765291
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ACTIVE MOIETY