GLISOXEPIDE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H27N5O5S
Molecular Weight	449.524
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of GLISOXEPIDE

Structure Search

SMILES

CC1=CC(=NO1)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NN3CCCCCC3

InChI

InChIKey=ZKUDBRCEOBOWLF-UHFFFAOYSA-N

InChI=1S/C20H27N5O5S/c1-15-14-18(23-30-15)19(26)21-11-10-16-6-8-17(9-7-16)31(28,29)24-20(27)22-25-12-4-2-3-5-13-25/h6-9,14H,2-5,10-13H2,1H3,(H,21,26)(H2,22,24,27)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/235462 | https://www.ncbi.nlm.nih.gov/pubmed/1618280 | https://www.ncbi.nlm.nih.gov/pubmed/5004178

Glisoxepide (BS 4231) is a sulfonylurea compound with glucose-lowering activity. Glisoxepide is a specific inhibitor of the L- aspartate/L-glutamate antiport system. Glisoxepide also inhibits transport of bile acids into hepatocytes

Approval Year

PubMed

PubMed

Title	Date	PubMed
Identification and quantification of 8 sulfonylureas with clinical toxicology interest by liquid chromatography-ion-trap tandem mass spectrometry and library searching.	2005 Sep	16020498
Bepridil, an antiarrhythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotection.	2006 Jan	16174795

Patents

Patents

Name

Type

Language

BAY-B-4231

Preferred Name

English

GLISOXEPIDE

Official Name

English

1-(HEXAHYDRO-1H-AZEPIN-1-YL)-3-((P-(2-(5-METHYL-3-ISOXAZOLECARBOXAMIDO)ETHYL)PHENYL)SULFONYL)UREA

Common Name

English

RP-22410

Code

English

FBB-4231

Code

English

FBB 4231

Code

English

GLISOXEPIDE [MART.]

Common Name

English

GLISOXEPID [MI]

Common Name

English

RP 22410

Code

English

glisoxepide [INN]

Common Name

English

BAY B 4231

Code

English

Glisoxepide [WHO-DD]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QA10BB11

Created by admin on Mon Mar 31 17:58:57 GMT 2025 , Edited by admin on Mon Mar 31 17:58:57 GMT 2025

NCI_THESAURUS

C97936

Created by admin on Mon Mar 31 17:58:57 GMT 2025 , Edited by admin on Mon Mar 31 17:58:57 GMT 2025

WHO-ATC

A10BB11

Created by admin on Mon Mar 31 17:58:57 GMT 2025 , Edited by admin on Mon Mar 31 17:58:57 GMT 2025

Code System Code Type Description

NCI_THESAURUS

C72801

Created by admin on Mon Mar 31 17:58:57 GMT 2025 , Edited by admin on Mon Mar 31 17:58:57 GMT 2025

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CAS

25046-79-1

Created by admin on Mon Mar 31 17:58:57 GMT 2025 , Edited by admin on Mon Mar 31 17:58:57 GMT 2025

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ECHA (EC/EINECS)

246-579-5

Created by admin on Mon Mar 31 17:58:57 GMT 2025 , Edited by admin on Mon Mar 31 17:58:57 GMT 2025

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SMS_ID

100000084205

Created by admin on Mon Mar 31 17:58:57 GMT 2025 , Edited by admin on Mon Mar 31 17:58:57 GMT 2025

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DRUG BANK

DB01289

Created by admin on Mon Mar 31 17:58:57 GMT 2025 , Edited by admin on Mon Mar 31 17:58:57 GMT 2025

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PUBCHEM

32778

Created by admin on Mon Mar 31 17:58:57 GMT 2025 , Edited by admin on Mon Mar 31 17:58:57 GMT 2025

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INN

2923

Created by admin on Mon Mar 31 17:58:57 GMT 2025 , Edited by admin on Mon Mar 31 17:58:57 GMT 2025

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FDA UNII

H7SC0I332I

Created by admin on Mon Mar 31 17:58:57 GMT 2025 , Edited by admin on Mon Mar 31 17:58:57 GMT 2025

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MERCK INDEX

m5749

Created by admin on Mon Mar 31 17:58:57 GMT 2025 , Edited by admin on Mon Mar 31 17:58:57 GMT 2025

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Merck Index

EPA CompTox

DTXSID9023097

Created by admin on Mon Mar 31 17:58:57 GMT 2025 , Edited by admin on Mon Mar 31 17:58:57 GMT 2025

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DRUG CENTRAL

1305

Created by admin on Mon Mar 31 17:58:57 GMT 2025 , Edited by admin on Mon Mar 31 17:58:57 GMT 2025

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WIKIPEDIA

GLISOXEPIDE

Created by admin on Mon Mar 31 17:58:57 GMT 2025 , Edited by admin on Mon Mar 31 17:58:57 GMT 2025

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ChEMBL

CHEMBL2106618

Created by admin on Mon Mar 31 17:58:57 GMT 2025 , Edited by admin on Mon Mar 31 17:58:57 GMT 2025

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EVMPD

SUB07933MIG

Created by admin on Mon Mar 31 17:58:57 GMT 2025 , Edited by admin on Mon Mar 31 17:58:57 GMT 2025

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ACTIVE MOIETY


					H7SC0I332I