GLISOXEPIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H27N5O5S
Molecular Weight	449.524
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC(=NO1)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NN3CCCCCC3

InChI

InChIKey=ZKUDBRCEOBOWLF-UHFFFAOYSA-N

InChI=1S/C20H27N5O5S/c1-15-14-18(23-30-15)19(26)21-11-10-16-6-8-17(9-7-16)31(28,29)24-20(27)22-25-12-4-2-3-5-13-25/h6-9,14H,2-5,10-13H2,1H3,(H,21,26)(H2,22,24,27)

HIDE SMILES / InChI

Molecular Formula	C20H27N5O5S
Molecular Weight	449.524
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/235462 | https://www.ncbi.nlm.nih.gov/pubmed/1618280 | https://www.ncbi.nlm.nih.gov/pubmed/5004178

Glisoxepide (BS 4231) is a sulfonylurea compound with glucose-lowering activity. Glisoxepide is a specific inhibitor of the L- aspartate/L-glutamate antiport system. Glisoxepide also inhibits transport of bile acids into hepatocytes

Approval Year

PubMed

Title	Date	PubMed
Screening, library-assisted identification and validated quantification of oral antidiabetics of the sulfonylurea-type in plasma by atmospheric pressure chemical ionization liquid chromatography-mass spectrometry.	2002 Jun 15	12015271
Antidiabetic sulphonylureas activate mitochondrial permeability transition in rat skeletal muscle.	2005 Jul	15895111
Identification and quantification of 8 sulfonylureas with clinical toxicology interest by liquid chromatography-ion-trap tandem mass spectrometry and library searching.	2005 Sep	16020498
Bepridil, an antiarrhythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotection.	2006 Jan	16174795

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:29:35 GMT 2023` Edited by `admin` on `Fri Dec 15 15:29:35 GMT 2023`
Record UNII	H7SC0I332I
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GLISOXEPIDE

Official Name

English

BAY-B-4231

Code

English

1-(HEXAHYDRO-1H-AZEPIN-1-YL)-3-((P-(2-(5-METHYL-3-ISOXAZOLECARBOXAMIDO)ETHYL)PHENYL)SULFONYL)UREA

Common Name

English

RP-22410

Code

English

FBB-4231

Code

English

FBB 4231

Code

English

GLISOXEPIDE [MART.]

Common Name

English

GLISOXEPID [MI]

Common Name

English

RP 22410

Code

English

glisoxepide [INN]

Common Name

English

BAY B 4231

Code

English

Glisoxepide [WHO-DD]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QA10BB11