Details
Stereochemistry | ACHIRAL |
Molecular Formula | C12H14N2.2ClH |
Molecular Weight | 259.175 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.NCCNC1=C2C=CC=CC2=CC=C1
InChI
InChIKey=MZNYWPRCVDMOJG-UHFFFAOYSA-N
InChI=1S/C12H14N2.2ClH/c13-8-9-14-12-7-3-5-10-4-1-2-6-11(10)12;;/h1-7,14H,8-9,13H2;2*1H
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL4789 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20590092 |
48.0 nM [Ki] | ||
Target ID: CHEMBL3729 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20590092 |
58.0 nM [Ki] | ||
Target ID: CHEMBL3969 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20590092 |
61.0 nM [Ki] |
PubMed
Title | Date | PubMed |
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Validation of a CE assay for the analysis of isomeric aminopyridines and diaminopyridines. | 2001 Feb |
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Sensitive spectrophotometric determination of nitrite in human saliva and rain water and of nitrogen dioxide in the atmosphere. | 2001 Jan-Feb |
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Determination of nitrite by sequential injection analysis of electrokinetic flow analysis system. | 2002 Mar 11 |
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Diagnostic value of protein induced by vitamin K absence (PIVKAII) and hepatoma-specific band of serum gamma-glutamyl transferase (GGTII) as hepatocellular carcinoma markers complementary to alpha-fetoprotein. | 2003 Jun 16 |
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[Evaluation of a colorimetric method for studying the interaction between microorganisms and intestinal epithelial cells]. | 2003 Oct-Dec |
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Flow-injection simultaneous determination of selenium(IV) and selenium(IV + VI) using photooxidative coupling of p-hydrazinobensenesulfonic acid with N-(1-naphthyl)ethylenediamine. | 2004 Dec 15 |
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Determination of mimosine by a sensitive indirect spectrophotometric method. | 2004 Jun 17 |
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[Highly sensitive spectrofluorimetric determination of trace amounts of nitrite with N-(1-naphthyl) ethylenediamine]. | 2005 Aug |
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Studies of selenium in environmental samples and synthetic mixtures by spectrophotometry. | 2006 Feb |
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Spectrophotometric determination of V(V) in environmental, biological, pharmaceutical and alloy samples by novel oxidative coupling reactions. | 2007 Feb 9 |
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Biological characteristics of Chinese hamster ovary cells transfected with bovine Prnp. | 2007 Jun |
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Application of genomic biomarkers to predict increased lung tumor incidence in 2-year rodent cancer bioassays. | 2007 May |
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Effects of nebulized ketamine on allergen-induced airway hyperresponsiveness and inflammation in actively sensitized Brown-Norway rats. | 2007 May 4 |
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Ameliorative role of Atorvastatin and Pitavastatin in L-Methionine induced vascular dementia in rats. | 2008 Aug 9 |
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Rosiglitazone inhibits metastasis development of a murine mammary tumor cell line LMM3. | 2008 Feb 8 |
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Bioavailable constituents/metabolites of pomegranate (Punica granatum L) preferentially inhibit COX2 activity ex vivo and IL-1beta-induced PGE2 production in human chondrocytes in vitro. | 2008 Jun 13 |
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Development and validation of spectrophotometric methods for determination of ceftazidime in pharmaceutical dosage forms. | 2008 Sep |
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Digestive proteolytic activity in the Sunn pest, Eurygaster integriceps. | 2009 |
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Purification and characterization of a lectin from Phaseolus vulgaris cv. (Anasazi beans). | 2009 |
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Pro-inflammatory and oxidative stress pathways which compromise sperm motility and survival may be altered by L-carnitine. | 2009 Apr-Jun |
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Liquid-phase microextraction and fibre-optics-based cuvetteless CCD-array micro-spectrophotometry for trace analysis. | 2009 Aug 26 |
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Nitric oxide bioavailability and its potential relevance to the variation in susceptibility to the renal and vascular complications in patients with type 2 diabetes. | 2009 Jan |
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Anti-inflammatory effects of the gorgonian Pseudopterogorgia elisabethae collected at the Islands of Providencia and San Andrés (SW Caribbean). | 2009 Mar 10 |
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Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue. | 2009 May 20 |
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Immunostimulatory Effects of Cordyceps militaris on Macrophages through the Enhanced Production of Cytokines via the Activation of NF-kappaB. | 2010 Apr |
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The Ca2+ activated SK3 channel is expressed in microglia in the rat striatum and contributes to microglia-mediated neurotoxicity in vitro. | 2010 Jan 14 |
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Tetrahydroabietic Acid, a Reduced Abietic Acid, Inhibits the Production of Inflammatory Mediators in RAW264.7 Macrophages Activated with Lipopolysaccharide. | 2010 Mar |
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Protection against LPS-induced cartilage inflammation and degradation provided by a biological extract of Mentha spicata. | 2010 May 11 |
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EGb761 protects motoneurons against avulsion-induced oxidative stress in rats. | 2010 May 24 |
Patents
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9849
Created by
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m7761
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2877
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C008588
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1465-25-4
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215-981-2
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H734599KJL
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DTXSID8020917
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15106
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PARENT (SALT/SOLVATE)
SUBSTANCE RECORD