Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H14N2.2ClH |
| Molecular Weight | 259.175 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.NCCNC1=C2C=CC=CC2=CC=C1
InChI
InChIKey=MZNYWPRCVDMOJG-UHFFFAOYSA-N
InChI=1S/C12H14N2.2ClH/c13-8-9-14-12-7-3-5-10-4-1-2-6-11(10)12;;/h1-7,14H,8-9,13H2;2*1H
| Molecular Formula | C12H14N2 |
| Molecular Weight | 186.253 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL4789 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20590092 |
48.0 nM [Ki] | ||
Target ID: CHEMBL3729 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20590092 |
58.0 nM [Ki] | ||
Target ID: CHEMBL3969 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20590092 |
61.0 nM [Ki] |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Acacia Senegal gum exudate offers protection against cyclophosphamide-induced urinary bladder cytotoxicity. | 2010-08-19 |
|
| Resveratrol differentially modulates inflammatory responses of microglia and astrocytes. | 2010-08-17 |
|
| Effect of taurine supplementation on hyperhomocysteinemia and markers of oxidative stress in high fructose diet induced insulin resistance. | 2010-06-30 |
|
| Design of group IIA secreted/synovial phospholipase A(2) inhibitors: an oxadiazolone derivative suppresses chondrocyte prostaglandin E(2) secretion. | 2010-06-01 |
|
| EGb761 protects motoneurons against avulsion-induced oxidative stress in rats. | 2010-05-24 |
|
| On-line analysis of volatile fatty acids in anaerobic treatment processes. | 2010-05-23 |
|
| Flow-injection catalytic spectrophotometic determination of molybdenum(VI) in plants using bromate oxidative coupling of p-hydrazinobensenesulfonic acid with N-(1-naphthyl)ethylenediamine. | 2010-05-15 |
|
| Protection against LPS-induced cartilage inflammation and degradation provided by a biological extract of Mentha spicata. | 2010-05-11 |
|
| Effect of St. John's Wort (Hypericum perforatum) treatment on restraint stress-induced behavioral and biochemical alteration in mice. | 2010-05-07 |
|
| Immunostimulatory Effects of Cordyceps militaris on Macrophages through the Enhanced Production of Cytokines via the Activation of NF-kappaB. | 2010-04 |
|
| Tetrahydroabietic Acid, a Reduced Abietic Acid, Inhibits the Production of Inflammatory Mediators in RAW264.7 Macrophages Activated with Lipopolysaccharide. | 2010-03 |
|
| Inhibition of inducible nitric oxide synthase prevents mitochondrial damage and improves survival of steatotic partial liver grafts. | 2010-02-15 |
|
| The Ca2+ activated SK3 channel is expressed in microglia in the rat striatum and contributes to microglia-mediated neurotoxicity in vitro. | 2010-01-14 |
|
| Vaccination of mice with salmonella expressing VapA: mucosal and systemic Th1 responses provide protection against Rhodococcus equi infection. | 2010-01-13 |
|
| Suppression of inflammatory mediators by cruciferous vegetable-derived indole-3-carbinol and phenylethyl isothiocyanate in lipopolysaccharide-activated macrophages. | 2010 |
|
| Development and validation of spectrophotometric methods for estimating amisulpride in pharmaceutical preparations. | 2010 |
|
| Acanthopanax koreanum fruit waste inhibits lipopolysaccharide-induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages. | 2010 |
|
| The unexpected role for the aryl hydrocarbon receptor on susceptibility to experimental toxoplasmosis. | 2010 |
|
| Sources of variation for indoor nitrogen dioxide in rural residences of Ethiopia. | 2009-11-18 |
|
| Pichinde virus induces microvascular endothelial cell permeability through the production of nitric oxide. | 2009-10-08 |
|
| In vitro antioxidant and antihyperlipidemic activities of Bauhinia variegata Linn. | 2009-10 |
|
| Liquid-phase microextraction and fibre-optics-based cuvetteless CCD-array micro-spectrophotometry for trace analysis. | 2009-08-26 |
|
| Crocetin reduces TNBS-induced experimental colitis in mice by downregulation of NFkB. | 2009-07-29 |
|
| Cordycepin Suppresses Expression of Diabetes Regulating Genes by Inhibition of Lipopolysaccharide-induced Inflammation in Macrophages. | 2009-06 |
|
| [Determination of the daily changes curve of nitrogen oxides in the atmosphere by digital imaging colorimetry method]. | 2009-06 |
|
| Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue. | 2009-05-20 |
|
| Estimation of nitric oxide as an inflammatory marker in periodontitis. | 2009-05 |
|
| Alternative spectrofluorimetric determination of short-chain volatile fatty acids in aqueous samples. | 2009-04-15 |
|
| Anti-inflammatory effects of the gorgonian Pseudopterogorgia elisabethae collected at the Islands of Providencia and San Andrés (SW Caribbean). | 2009-03-10 |
|
| Acute seizure activity promotes lipid peroxidation, increased nitrite levels and adaptive pathways against oxidative stress in the frontal cortex and striatum. | 2009-03-01 |
|
| Effects of L-NAME, a non-specific nitric oxide synthase inhibitor, on AlCl3-induced toxicity in the rat forebrain cortex. | 2009-03 |
|
| Pro-inflammatory and oxidative stress pathways which compromise sperm motility and survival may be altered by L-carnitine. | 2009-02-11 |
|
| Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells. | 2009-01-05 |
|
| Digestive proteolytic activity in the Sunn pest, Eurygaster integriceps. | 2009 |
|
| Nitric oxide production by the human intestinal microbiota by dissimilatory nitrate reduction to ammonium. | 2009 |
|
| Purification and characterization of a lectin from Phaseolus vulgaris cv. (Anasazi beans). | 2009 |
|
| Lack of galectin-3 drives response to Paracoccidioides brasiliensis toward a Th2-biased immunity. | 2009 |
|
| Antioxidant and free radical scavenging activity of Spondias pinnata. | 2008-12-09 |
|
| Enhanced production of nitric oxide, reactive oxygen species, and pro-inflammatory cytokines in very long chain saturated fatty acid-accumulated macrophages. | 2008-11-28 |
|
| Development of a selective and sensitive spectrophotometric method for the trace determination of thallium(III) using 3-methyl-2-benzothiazolinone hydrazone hydrochloride and N-(1-naphthyl)-ethylenediamine dihydrochloride. | 2008-11-05 |
|
| Role of vitamins C and e in regulating antioxidant and pro-oxidant markers in preeclampsia. | 2008-11 |
|
| Determination of ortho-phthalaldehyde in air and on surfaces. | 2008-11 |
|
| Development and validation of spectrophotometric methods for determination of ceftazidime in pharmaceutical dosage forms. | 2008-09 |
|
| Abstracts of papers presented at the 2008 pittsburgh conference. | 2008 |
|
| A novel method for the spectrophotometric determination of nitrite in water. | 2005-06-15 |
|
| Flow-injection simultaneous determination of selenium(IV) and selenium(IV + VI) using photooxidative coupling of p-hydrazinobensenesulfonic acid with N-(1-naphthyl)ethylenediamine. | 2004-12-15 |
|
| Determination of mimosine by a sensitive indirect spectrophotometric method. | 2004-06-17 |
|
| Spectrophotometric flow-injection determination of zinc in plant digests based on a spot test. | 2004-05-28 |
|
| The application of the chromatomembrane cell for the absorptive sampling of nitrogen dioxide followed by continuous determination of nitrite using a micro-flow injection system. | 2002-05-16 |
|
| Determination of nitrite by sequential injection analysis of electrokinetic flow analysis system. | 2002-03-11 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:51:33 GMT 2025
by
admin
on
Mon Mar 31 18:51:33 GMT 2025
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| Record UNII |
H734599KJL
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| Record Status |
Validated (UNII)
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| Record Version |
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9849
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m7761
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2877
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C008588
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1465-25-4
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215-981-2
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H734599KJL
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DTXSID8020917
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15106
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