Details
Stereochemistry | ACHIRAL |
Molecular Formula | C12H14N2.2ClH |
Molecular Weight | 259.175 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.NCCNC1=C2C=CC=CC2=CC=C1
InChI
InChIKey=MZNYWPRCVDMOJG-UHFFFAOYSA-N
InChI=1S/C12H14N2.2ClH/c13-8-9-14-12-7-3-5-10-4-1-2-6-11(10)12;;/h1-7,14H,8-9,13H2;2*1H
Molecular Formula | C12H14N2 |
Molecular Weight | 186.253 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL4789 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20590092 |
48.0 nM [Ki] | ||
Target ID: CHEMBL3729 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20590092 |
58.0 nM [Ki] | ||
Target ID: CHEMBL3969 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20590092 |
61.0 nM [Ki] |
PubMed
Title | Date | PubMed |
---|---|---|
Determination of nitrite by sequential injection analysis of electrokinetic flow analysis system. | 2002 Mar 11 |
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The application of the chromatomembrane cell for the absorptive sampling of nitrogen dioxide followed by continuous determination of nitrite using a micro-flow injection system. | 2002 May 16 |
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Flow-injection simultaneous determination of selenium(IV) and selenium(IV + VI) using photooxidative coupling of p-hydrazinobensenesulfonic acid with N-(1-naphthyl)ethylenediamine. | 2004 Dec 15 |
|
Determination of mimosine by a sensitive indirect spectrophotometric method. | 2004 Jun 17 |
|
Spectrophotometric flow-injection determination of zinc in plant digests based on a spot test. | 2004 May 28 |
|
A novel method for the spectrophotometric determination of nitrite in water. | 2005 Jun 15 |
|
Abstracts of papers presented at the 2008 pittsburgh conference. | 2008 |
|
Antioxidant and free radical scavenging activity of Spondias pinnata. | 2008 Dec 9 |
|
Role of vitamins C and e in regulating antioxidant and pro-oxidant markers in preeclampsia. | 2008 Nov |
|
Determination of ortho-phthalaldehyde in air and on surfaces. | 2008 Nov |
|
Enhanced production of nitric oxide, reactive oxygen species, and pro-inflammatory cytokines in very long chain saturated fatty acid-accumulated macrophages. | 2008 Nov 28 |
|
Development and validation of spectrophotometric methods for determination of ceftazidime in pharmaceutical dosage forms. | 2008 Sep |
|
Development of a selective and sensitive spectrophotometric method for the trace determination of thallium(III) using 3-methyl-2-benzothiazolinone hydrazone hydrochloride and N-(1-naphthyl)-ethylenediamine dihydrochloride. | 2008 Sep-Oct |
|
Digestive proteolytic activity in the Sunn pest, Eurygaster integriceps. | 2009 |
|
Nitric oxide production by the human intestinal microbiota by dissimilatory nitrate reduction to ammonium. | 2009 |
|
Purification and characterization of a lectin from Phaseolus vulgaris cv. (Anasazi beans). | 2009 |
|
Lack of galectin-3 drives response to Paracoccidioides brasiliensis toward a Th2-biased immunity. | 2009 |
|
Alternative spectrofluorimetric determination of short-chain volatile fatty acids in aqueous samples. | 2009 Apr 15 |
|
Pro-inflammatory and oxidative stress pathways which compromise sperm motility and survival may be altered by L-carnitine. | 2009 Apr-Jun |
|
Liquid-phase microextraction and fibre-optics-based cuvetteless CCD-array micro-spectrophotometry for trace analysis. | 2009 Aug 26 |
|
Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells. | 2009 Jan 5 |
|
Acute seizure activity promotes lipid peroxidation, increased nitrite levels and adaptive pathways against oxidative stress in the frontal cortex and striatum. | 2009 Jul-Aug |
|
Crocetin reduces TNBS-induced experimental colitis in mice by downregulation of NFkB. | 2009 Jul-Sep |
|
Cordycepin Suppresses Expression of Diabetes Regulating Genes by Inhibition of Lipopolysaccharide-induced Inflammation in Macrophages. | 2009 Jun |
|
[Determination of the daily changes curve of nitrogen oxides in the atmosphere by digital imaging colorimetry method]. | 2009 Jun |
|
Effects of L-NAME, a non-specific nitric oxide synthase inhibitor, on AlCl3-induced toxicity in the rat forebrain cortex. | 2009 Mar |
|
Anti-inflammatory effects of the gorgonian Pseudopterogorgia elisabethae collected at the Islands of Providencia and San Andrés (SW Caribbean). | 2009 Mar 10 |
|
Estimation of nitric oxide as an inflammatory marker in periodontitis. | 2009 May |
|
Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue. | 2009 May 20 |
|
Sources of variation for indoor nitrogen dioxide in rural residences of Ethiopia. | 2009 Nov 18 |
|
In vitro antioxidant and antihyperlipidemic activities of Bauhinia variegata Linn. | 2009 Oct |
|
Pichinde virus induces microvascular endothelial cell permeability through the production of nitric oxide. | 2009 Oct 8 |
|
Acacia Senegal gum exudate offers protection against cyclophosphamide-induced urinary bladder cytotoxicity. | 2009 Sep-Oct |
|
Suppression of inflammatory mediators by cruciferous vegetable-derived indole-3-carbinol and phenylethyl isothiocyanate in lipopolysaccharide-activated macrophages. | 2010 |
|
Development and validation of spectrophotometric methods for estimating amisulpride in pharmaceutical preparations. | 2010 |
|
Acanthopanax koreanum fruit waste inhibits lipopolysaccharide-induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages. | 2010 |
|
The unexpected role for the aryl hydrocarbon receptor on susceptibility to experimental toxoplasmosis. | 2010 |
|
Immunostimulatory Effects of Cordyceps militaris on Macrophages through the Enhanced Production of Cytokines via the Activation of NF-kappaB. | 2010 Apr |
|
Resveratrol differentially modulates inflammatory responses of microglia and astrocytes. | 2010 Aug 17 |
|
Inhibition of inducible nitric oxide synthase prevents mitochondrial damage and improves survival of steatotic partial liver grafts. | 2010 Feb 15 |
|
Vaccination of mice with salmonella expressing VapA: mucosal and systemic Th1 responses provide protection against Rhodococcus equi infection. | 2010 Jan 13 |
|
The Ca2+ activated SK3 channel is expressed in microglia in the rat striatum and contributes to microglia-mediated neurotoxicity in vitro. | 2010 Jan 14 |
|
Design of group IIA secreted/synovial phospholipase A(2) inhibitors: an oxadiazolone derivative suppresses chondrocyte prostaglandin E(2) secretion. | 2010 Jun 1 |
|
Effect of taurine supplementation on hyperhomocysteinemia and markers of oxidative stress in high fructose diet induced insulin resistance. | 2010 Jun 30 |
|
Tetrahydroabietic Acid, a Reduced Abietic Acid, Inhibits the Production of Inflammatory Mediators in RAW264.7 Macrophages Activated with Lipopolysaccharide. | 2010 Mar |
|
Protection against LPS-induced cartilage inflammation and degradation provided by a biological extract of Mentha spicata. | 2010 May 11 |
|
Flow-injection catalytic spectrophotometic determination of molybdenum(VI) in plants using bromate oxidative coupling of p-hydrazinobensenesulfonic acid with N-(1-naphthyl)ethylenediamine. | 2010 May 15 |
|
On-line analysis of volatile fatty acids in anaerobic treatment processes. | 2010 May 23 |
|
EGb761 protects motoneurons against avulsion-induced oxidative stress in rats. | 2010 May 24 |
|
Effect of St. John's Wort (Hypericum perforatum) treatment on restraint stress-induced behavioral and biochemical alteration in mice. | 2010 May 7 |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:45:16 UTC 2023
by
admin
on
Fri Dec 15 17:45:16 UTC 2023
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Record UNII |
H734599KJL
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Record Status |
Validated (UNII)
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Record Version |
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9849
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m7761
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2877
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C008588
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1465-25-4
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215-981-2
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H734599KJL
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DTXSID8020917
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15106
Created by
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