Thiourea

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	CH4N2S
Molecular Weight	76.121
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(N)=S

InChI

InChIKey=UMGDCJDMYOKAJW-UHFFFAOYSA-N

InChI=1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)

HIDE SMILES / InChI

Approval Year

PubMed

Title	Date	PubMed
Suppression of Ca2+ influx through L-type voltage-dependent calcium channels by hydroxyl radical in mouse cerebral cortical neurons.	2001-08-15	11483237
Alleviation of wood smoke-induced lung injury by tachykinin receptor antagonist and hydroxyl radical scavenger in guinea pigs.	2001-08-10	11502280
Synthesis of some pyridone derivatives.	2001-08-07	11486604
Role of the reverse mode of the Na+/Ca2+ exchanger in reoxygenation-induced cardiomyocyte injury.	2001-08-01	11470463
Cardiac sodium-calcium exchanger: a double-edged sword.	2001-08-01	11470457
Role of nNOS in regulation of renal function in angiotensin II-induced hypertension.	2001-08	11509490
Inhibition of Na+/Ca2+ exchange with KB-R7943 or bepridil diminished mineral deposition by osteoblasts.	2001-08	11499866
Neuroprotective and neurorescuing effects of isoform-specific nitric oxide synthase inhibitors, nitric oxide scavenger, and antioxidant against beta-amyloid toxicity.	2001-08	11487523
Influence of sediment and pore-water composition on nitrite accumulation in a nitrate-perfused freshwater sediment.	2001-08	11471681
Implications for isoform-selective inhibitor design derived from the binding mode of bulky isothioureas to the heme domain of endothelial nitric-oxide synthase.	2001-07-13	11331290
[Synthesis of 1-hydroxyalkyl-3-substituted ureas and thioureas as a substrates for alcohol dehydrogenase].	2001-07-11	11443945
Some 3-thioxo/alkylthio-1,2,4-triazoles with a substituted thiourea moiety as possible antimycobacterials.	2001-07-09	11425542
Thiourea enhances mapping of the proteome from murine white adipose tissue.	2001-07	11503206
Effects of the cardioselective KATP channel blocker HMR 1098 on cardiac function in isolated perfused working rat hearts and in anesthetized rats during ischemia and reperfusion.	2001-07	11485036
A proving of Thiosinamine.	2001-07	11479789
Sodium-calcium exchanger (NCX-1) and calcium modulation: NCX protein expression patterns and regulation of early heart development.	2001-07	11458386
Chlorotris(N,N'-dicyclohexylthiourea-S)tellurium(II) chloride, a tellurium complex with a TeClS3 coordination sphere.	2001-07	11443265
The effect of thiolate organic compounds on methylmercury accumulation and redistribution in sheepshead minnows, Cyprinodon variegatus.	2001-07	11434298
Synthesis of plaunotol derivatives and their antibacterial activities against Helicobacter pylori.	2001-07	11425580
N-(3-acyloxy-2-benzylpropyl)-N'-dihydroxytetrahydrobenzazepine and tetrahydroisoquinoline thiourea analogues as vanilloid receptor ligands.	2001-07	11425572
SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models.	2001-07	11408549
Capillary-electrochromatographic separations with copolymeric reversed-stationary phase and ion-exchanger-packed columns.	2001-06-22	11453022
Role of nitric oxide in human gastric cancer cells treated with 5-fluorouracil.	2001-06-19	11410796
Synthesis and characterization of CdIn(2)S(4) nanorods by converting CdS nanorods via the hydrothermal route.	2001-06-18	11399183
Metamorphosis of summer flounder, Paralichthys dentatus: cell proliferation and differentiation of the gastric mucosa and developmental effects of altered thyroidal status.	2001-06-15	11429761
Competitive sorption of platinum and palladium on chitosan derivatives.	2001-06-12	11325428
A novel method of studying wound healing.	2001-06-01	11368532
Protein alkylation in the presence/absence of thiourea in proteome analysis: a matrix assisted laser desorption/ionization-time of flight-mass spectrometry investigation.	2001-06	11465507
Influence of neutral cyclodextrin concentration on plate numbers in capillary electrophoresis.	2001-06	11465494
An immunoblotting method for high-resolution isoelectric focusing of protein isoforms on immobilized pH gradients.	2001-06	11465484
Silver ion microplates for immunoassays.	2001-06	11414228
Aminoethyl-isothiourea inhibits leukocyte production of reactive oxygen species and proinflammatory cytokines induced by streptococcal cell wall components in human whole blood.	2001-06	11386618
Aminoethyl-isothiourea in gram-positive shock: an inhibitor of inducible nitric oxide synthase or a jack-of-all-trades?	2001-06	11386617
Aminoethyl-isothiourea inhibits the increase in plasma endothelin-1 caused by serogroup A streptococci and prolongs survival in rat peritoneal sepsis.	2001-06	11386616
Effect of a series of novel sulphonylthioureas on glucose tolerance in the obese fa/fa Zucker rat.	2001-05-31	11380511
Lipopolysaccharide-induced cell cycle arrest in macrophages occurs independently of nitric oxide synthase II induction.	2001-05-28	11389976
Thiols in coastal waters of the western North Sea and English Channel.	2001-05-15	11393967
Combinatorial synthesis of heterocycles: solid-phase synthesis of 6-amino-2,4-dioxo-3,4-dihydro-1,3,5-triazine derivatives.	2001-05-15	11350251
The effects of the Na(+)/Ca(++) exchange blocker on osmotic blood-brain barrier disruption.	2001-05-11	11334793
Histamine H3 receptor-mediated inhibition of sympathetically evoked mydriasis in rats.	2001-05-04	11348630
Histamine H(3) receptor-mediated inhibition of depolarization-induced, dopamine D(1) receptor-dependent release of [(3)H]-gamma-aminobutryic acid from rat striatal slices.	2001-05	11325806
Thiouracil antithyroid drugs as a new class of neuronal nitric oxide synthase inhibitors.	2001-04-06	11401533
Catalysis and inhibition of ligand substitution in palladium(II) square-planar complexes: effects of DNA.	2001-03-07	11456812
Carbohydrate-based receptors with multiple thiourea binding sites. Multipoint hydrogen bond recognition of dicarboxylates and monosaccharides.	2001-02-23	11312968
Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent.	2001-02-01	11462972
In vivo toxicity, pharmacokinetic features and tissue distribution of N-[2-(2,5-dimethoxyphenylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-236), a potent non-nucleoside inhibitor of HIV-1 reverse transcriptase.	2001	11505789
Iron-induced oxidative stress up-regulates calreticulin levels in intestinal epithelial (Caco-2) cells.	2001	11500943
Inhibition of lung natural killer cell activity by smoking: the role of alveolar macrophages.	2001	11416246
Evaluation of nitrification-inhibition measurements.	2001	11379092
[The Na+/Ca2+ exchanger as responsible for myocardial stunning].	2001	11374139

Patents

Name

Type

Language

NSC-5033

Preferred Name

English

Thiourea

Official Name

English

THIOUREA [HSDB]

Common Name

English

THIOCARBAMIDE

Common Name

English

THIOUREA [IARC]

Common Name

English

Thiourea [WHO-DD]

Common Name

English

PROPYLTHIOURACIL IMPURITY A [EP IMPURITY]

Common Name

English

THIOUREA [MI]

Common Name

English

2-THIOUREA

Common Name

English

THIOUREA [VANDF]

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 189.190