U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C17H14Cl2N2O2
Molecular Weight 349.211
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CLOXAZOLAM

SMILES

ClC1=CC2=C(NC(=O)CN3CCOC23C4=C(Cl)C=CC=C4)C=C1

InChI

InChIKey=ZIXNZOBDFKSQTC-UHFFFAOYSA-N
InChI=1S/C17H14Cl2N2O2/c18-11-5-6-15-13(9-11)17(12-3-1-2-4-14(12)19)21(7-8-23-17)10-16(22)20-15/h1-6,9H,7-8,10H2,(H,20,22)

HIDE SMILES / InChI
Cloxazolam is an agonist of GABA-A receptor that was developed in Japan for the treatment of anxiety-disorders. The drug was marketed in Europe under the names Sepazon, Olcadil, Akton and Lubalix.

Originator

Sources: www.ncbi.nlm.nih.gov/pubmed/4753311

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
OLCADIL

Approved Use

Emotional disorders such as anxiety, tension, restlessness; sleep disorders such as difficulty falling asleep, insomnia and early awakening; pre-medication prior to surgery.

Launch Date

2013
Primary
OLCADIL

Approved Use

Emotional disorders such as anxiety, tension, restlessness; sleep disorders such as difficulty falling asleep, insomnia and early awakening; pre-medication prior to surgery.

Launch Date

2013
PubMed

PubMed

TitleDatePubMed
[A case of amoxapine-induced tardive dystonia successfully treated with a low dose anti-cholinergic agent].
2000 Apr
Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone.
2003 Feb 1
Patents

Sample Use Guides

Symptoms of mild to moderate severity: a tablet (2 mg) and a half to three tablets per day, divided into two administrations; Symptoms of moderately severe to severe: 3 to 4 tablets per day divided in two administrations.The optimal therapeutic dosage should be determined individually by progressive adjustment. max recommended dose: 6 tablets (12 mg)/day.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
CLOXAZOLAM
INN   MART.   MI   WHO-DD  
INN  
Official Name English
cloxazolam [INN]
Common Name English
CLOXAZOLAM [JAN]
Common Name English
CLOXAZOLAM [MART.]
Common Name English
CLOXAZOLAM [MI]
Common Name English
10-CHLORO-11B-(O-CHLOROPHENYL)-2,3,7,11B-TETRAHYDRO-OXAZOLO(3,2-D) (1,4)BENZODIAZEPIN-6(5H)-ONE
Common Name English
Cloxazolam [WHO-DD]
Common Name English
SEPAZON
Brand Name English
Classification Tree Code System Code
DEA NO. 2753
Created by admin on Fri Dec 15 16:01:44 GMT 2023 , Edited by admin on Fri Dec 15 16:01:44 GMT 2023
WHO-ATC N05BA22
Created by admin on Fri Dec 15 16:01:44 GMT 2023 , Edited by admin on Fri Dec 15 16:01:44 GMT 2023
NCI_THESAURUS C28197
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WHO-VATC QN05BA22
Created by admin on Fri Dec 15 16:01:44 GMT 2023 , Edited by admin on Fri Dec 15 16:01:44 GMT 2023
Code System Code Type Description
ChEMBL
CHEMBL2107254
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PRIMARY
MERCK INDEX
m3674
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PRIMARY Merck Index
PUBCHEM
2816
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PRIMARY
NCI_THESAURUS
C79883
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PRIMARY
EVMPD
SUB06781MIG
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PRIMARY
SMS_ID
100000084056
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PRIMARY
WIKIPEDIA
CLOXAZOLAM
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PRIMARY
CAS
24166-13-0
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PRIMARY
DRUG CENTRAL
721
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PRIMARY
RXCUI
21311
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PRIMARY RxNorm
DRUG BANK
DB01553
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PRIMARY
MESH
C005522
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PRIMARY
FDA UNII
GYL649Z0HY
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PRIMARY
EPA CompTox
DTXSID0022854
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PRIMARY
INN
3400
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PRIMARY