U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C20H18N4O5S2.2H2O
Molecular Weight 494.541
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CEFALONIUM DIHYDRATE

SMILES

O.O.[H][C@]12SCC(C[N+]3=CC=C(C=C3)C(N)=O)=C(N1C(=O)[C@H]2NC(=O)CC4=CC=CS4)C([O-])=O

InChI

InChIKey=MJKBYXGLUCGDRX-LEVQAPRMSA-N
InChI=1S/C20H18N4O5S2.2H2O/c21-17(26)11-3-5-23(6-4-11)9-12-10-31-19-15(18(27)24(19)16(12)20(28)29)22-14(25)8-13-2-1-7-30-13;;/h1-7,15,19H,8-10H2,(H3-,21,22,25,26,28,29);2*1H2/t15-,19-;;/m1../s1

HIDE SMILES / InChI
Cefalonium is a 1st generation cephalosporin with a broad spectrum of actvity against Gram-positive and Gram-negative bacterias. The drug inhibits the bacterial cell wall synthesis by binding to penicillin binding proteins. Cefalonium is approved for routine dry cow therapy to treat existing sub-clinical infections and to prevent new infections which occur during the dry period.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
CEPRAVIN

Approved Use

In conjunction with, proper management of the cow during drying-off and over the dry period, correct administration of Cepravin Dry Cow at drying off: (1) Reduces new infections at drying off and in the dry period; (2) Treats subclinical mastitis that may be present at drying off; (3) Helps reduce SCC's and mastitis in the subsequent lactation.
PubMed

PubMed

TitleDatePubMed
Effect of an intramammary teat seal and dry cow antibiotic in relation to dry period length on postpartum mastitis.
2007 Feb
[Determination of 9 cephalosporin drug residues in beef by ultra performance liquid chromatography-tandem mass spectrometry].
2009 Jul
Development of a rapid multi-residue assay for detecting β-lactams using penicillin binding protein 2x*.
2013 Feb
Patents

Patents

Sample Use Guides

1 syringe (250 mg) per quarter immediately after final milking.
Route of Administration: Other
The activity of cefalonium against different bacterial strains was measured. The MIC90 values were: 0.125 ug/ml for Staphylococcus aureus, 0.0156 ug/ml for Streptococcus agalactiae, 0.0078 ug/ml for Streptococcus dysgalactiae, 0.06 ug/ml for Streptococcus uberis, 0.125 ug/ml for Arcanobacterium pyogenes, 2 ug/ml for Escherichia coli and Klebsiella spp.
Name Type Language
CEFALONIUM DIHYDRATE
Common Name English
PYRIDINIUM, 4-(AMINOCARBONYL)-1-(((6R,7R)-2-CARBOXY-8-OXO-7-((2-(2-THIENYL)ACETYL)AMINO)-5-THIA-1-AZABICYCLO(4.2.0)OCT-2-EN-3-YL)METHYL)-, INNER SALT, HYDRATE (1:2)
Systematic Name English
Code System Code Type Description
PUBCHEM
57519749
Created by admin on Sat Dec 16 18:05:49 GMT 2023 , Edited by admin on Sat Dec 16 18:05:49 GMT 2023
PRIMARY
CAS
1385046-35-4
Created by admin on Sat Dec 16 18:05:49 GMT 2023 , Edited by admin on Sat Dec 16 18:05:49 GMT 2023
PRIMARY
SMS_ID
300000023691
Created by admin on Sat Dec 16 18:05:49 GMT 2023 , Edited by admin on Sat Dec 16 18:05:49 GMT 2023
PRIMARY
FDA UNII
GMV4EAL4T7
Created by admin on Sat Dec 16 18:05:49 GMT 2023 , Edited by admin on Sat Dec 16 18:05:49 GMT 2023
PRIMARY