Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C20H18N4O5S2.2H2O |
| Molecular Weight | 494.541 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.[H][C@]12SCC(C[N+]3=CC=C(C=C3)C(N)=O)=C(N1C(=O)[C@H]2NC(=O)CC4=CC=CS4)C([O-])=O
InChI
InChIKey=MJKBYXGLUCGDRX-LEVQAPRMSA-N
InChI=1S/C20H18N4O5S2.2H2O/c21-17(26)11-3-5-23(6-4-11)9-12-10-31-19-15(18(27)24(19)16(12)20(28)29)22-14(25)8-13-2-1-7-30-13;;/h1-7,15,19H,8-10H2,(H3-,21,22,25,26,28,29);2*1H2/t15-,19-;;/m1../s1
| Molecular Formula | H2O |
| Molecular Weight | 18.0153 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C20H18N4O5S2 |
| Molecular Weight | 458.511 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Cefalonium is a 1st generation cephalosporin with a broad spectrum of actvity against Gram-positive and Gram-negative bacterias. The drug inhibits the bacterial cell wall synthesis by binding to penicillin binding proteins. Cefalonium is approved for routine dry cow therapy to treat existing sub-clinical infections and to prevent new infections which occur during the dry period.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2354204 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Curative | CEPRAVIN Approved UseIn conjunction with, proper management of the cow during drying-off and over the dry period, correct administration of Cepravin Dry Cow at drying off: (1) Reduces new infections at drying off and in the dry period; (2) Treats subclinical mastitis that may be present at drying off; (3) Helps reduce SCC's and mastitis in the subsequent lactation. |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Effect of an intramammary teat seal and dry cow antibiotic in relation to dry period length on postpartum mastitis. | 2007 Feb |
|
| [Determination of 9 cephalosporin drug residues in beef by ultra performance liquid chromatography-tandem mass spectrometry]. | 2009 Jul |
|
| Development of a rapid multi-residue assay for detecting β-lactams using penicillin binding protein 2x*. | 2013 Feb |
Patents
Sample Use Guides
1 syringe (250 mg) per quarter immediately after final milking.
Route of Administration:
Other
The activity of cefalonium against different bacterial strains was measured. The MIC90 values were: 0.125 ug/ml for Staphylococcus aureus, 0.0156 ug/ml for Streptococcus agalactiae, 0.0078 ug/ml for Streptococcus dysgalactiae, 0.06 ug/ml for Streptococcus uberis, 0.125 ug/ml for Arcanobacterium pyogenes, 2 ug/ml for Escherichia coli and Klebsiella spp.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 18:05:48 UTC 2023
by
admin
on
Sat Dec 16 18:05:48 UTC 2023
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| Record UNII |
GMV4EAL4T7
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| Record Status |
Validated (UNII)
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| Record Version |
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57519749
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1385046-35-4
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300000023691
Created by
admin on Sat Dec 16 18:05:49 UTC 2023 , Edited by admin on Sat Dec 16 18:05:49 UTC 2023
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GMV4EAL4T7
Created by
admin on Sat Dec 16 18:05:49 UTC 2023 , Edited by admin on Sat Dec 16 18:05:49 UTC 2023
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ANHYDROUS->SOLVATE |
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |
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