Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H12N2O.ClH |
| Molecular Weight | 212.676 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.NCCC1=CNC2=C1C=C(O)C=C2
InChI
InChIKey=MDIGAZPGKJFIAH-UHFFFAOYSA-N
InChI=1S/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H
Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter produced by serotonergic neurons in the CNS and enterochromaffin cells in the gastrointestinal tract. Pharmacologic action of serotonin is mediated by a large and diverse range of 5-HT receptors. Serotonin plays an important part in the biochemistry of depression, migraine, bipolar disorder, and anxiety. It is also believed to be influential on sexuality and appetite. Creatinine is a product of the metabolic breakdown of creatine phosphate in muscle. Creatinine is filtered by healthy kidneys. Serotonin creatinine sulfate complex was the first isolated salt form of serotonin.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Detailed examination of fenfluramine-phentermine users with valve abnormalities identified in Fargo, North Dakota. | 1999 Aug 1 |
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| Association between monoamine oxidase A activity in human male skin fibroblasts and genotype of the MAOA promoter-associated variable number tandem repeat. | 1999 Dec |
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| Actions of roxindole at recombinant human dopamine D2, D3 and D4 and serotonin 5-HT1A, 5-HT1B and 5-HT1D receptors. | 1999 Jun |
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| Serotonin in human allergic contact dermatitis. An immunohistochemical and high-performance liquid chromatographic study. | 1999 May |
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| The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit. | 1999 Oct 22 |
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| Isolation of the serotoninergic 5-HT4(e) receptor from human heart and comparative analysis of its pharmacological profile in C6-glial and CHO cell lines. | 2000 Feb |
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| Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant. | 2000 Feb |
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| Agonist high and low affinity state ratios predict drug intrinsic activity and a revised ternary complex mechanism at serotonin 5-HT(2A) and 5-HT(2C) receptors. | 2000 Feb |
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| The effect of fenfluramine on the pulmonary disposition of 5-hydroxytryptamine in the isolated perfused rat lung: a comparison with chlorphentermine. | 2000 Jan |
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| Effect of GBR 12909 and fluoxetine on the acute and long term changes induced by MDMA ('ecstasy') on the 5-HT and dopamine concentrations in mouse brain. | 2001 |
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| Influence of thyroid hormone on 5-HT(1A) and 5-HT(2A) receptor-mediated regulation of hippocampal BDNF mRNA expression. | 2001 |
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| Modulation of 5-HT(1A) receptor activation by its interaction with wild-type and mutant g(alphai3) proteins. | 2001 |
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| Peripheral interleukin-6 administration increases extracellular concentrations of serotonin and the evoked release of serotonin in the rat striatum. | 2001 Apr |
|
| Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily. | 2001 Apr 6 |
|
| New avenues in treatment of paediatric migraine: a review of the literature. | 2001 Feb |
|
| Presynaptic neuronal antigens expressed by a small cell lung carcinoma cell line. | 2001 Feb 1 |
|
| Biophysical characterization of the cocaine binding pocket in the serotonin transporter using a fluorescent cocaine analogue as a molecular reporter. | 2001 Feb 16 |
|
| Oligomerization of the human serotonin transporter and of the rat GABA transporter 1 visualized by fluorescence resonance energy transfer microscopy in living cells. | 2001 Feb 9 |
|
| Functional role of critical stripe residues in transmembrane span 7 of the serotonin transporter. Effects of Na+, Li+, and methanethiosulfonate reagents. | 2001 Feb 9 |
|
| Cisapride and dexamethasone in the prevention of delayed emesis after cisplatin administration. | 2001 Jan |
|
| Atrial arrhythmia in a woman treated with fluoxetine: is there a causal relationship? | 2001 Jan |
|
| Antisocial personality - part II. | 2001 Jan |
|
| Changes of biogenic amine levels in haemolymph during diapausing and non-diapausing status in Pieris brassicae L. | 2001 Jan |
|
| Chronic endothelial dysfunction after oversized coronary balloon angioplasty in pigs: a 12-week follow-up of coronary vasoreactivity in vivo and in vitro. | 2001 Jan |
|
| The effect of paroxetine on 5-HT(2A) receptors in depression: an [(18)F]setoperone PET imaging study. | 2001 Jan |
|
| Ondansetron hydrochloride for the treatment of delirium after coronary artery surgery. | 2001 Jan |
|
| Hypothesized treatment for migraines using low doses of tryptophan, niacin, calcium, caffeine, and acetylsalicylic acid. | 2001 Jan |
|
| The antidepressant-sensitive dopamine transporter in Drosophila melanogaster: a primordial carrier for catecholamines. | 2001 Jan |
|
| Effect of inhibition of MAO and COMT on intrarenal dopamine and serotonin and on renal function. | 2001 Jan |
|
| Vasoactive intestinal peptide: cardiovascular effects. | 2001 Jan |
|
| Rapid bidirectional modulation of mRNA expression and export accompany long-term facilitation and depression of Aplysia synapses. | 2001 Jan |
|
| Augmented accumbal serotonin levels decrease the preference for a morphine associated environment during withdrawal. | 2001 Jan |
|
| Lower baseline plasma cortisol and prolactin together with increased body temperature and higher mCPP-induced cortisol responses in men with pedophilia. | 2001 Jan |
|
| Low versus standard dose mCPP challenge in obsessive-compulsive patients. | 2001 Jan |
|
| Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin. | 2001 Jan |
|
| Neurotoxic regimen of methamphetamine produces evidence of behavioral sensitization in the rat. | 2001 Jan |
|
| Brain function in a patient with torture related post-traumatic stress disorder before and after fluoxetine treatment: a positron emission tomography provocation study. | 2001 Jan 12 |
|
| Inhibition of evoked glutamate release by the neuroprotective 5-HT(1A) receptor agonist BAY x 3702 in vitro and in vivo. | 2001 Jan 5 |
|
| M100,907, a selective 5-HT(2A) antagonist, attenuates dopamine release in the rat medial prefrontal cortex. | 2001 Jan 5 |
|
| Functional effects of corticosterone on 5-HT(1A) and 5-HT(1B) receptor activity in rat brain: in vivo microdialysis studies. | 2001 Jan 5 |
|
| Functional reconstitution and characterization of recombinant human alpha 1-glycine receptors. | 2001 Jun 15 |
|
| The dynamin-dependent, arrestin-independent internalization of 5-hydroxytryptamine 2A (5-HT2A) serotonin receptors reveals differential sorting of arrestins and 5-HT2A receptors during endocytosis. | 2001 Mar 16 |
Patents
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| Code System | Code | Type | Description | ||
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160436
Created by
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m9871
Created by
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DBSALT002615
Created by
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GKN429M9VS
Created by
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DTXSID80165186
Created by
admin on Fri Dec 15 16:00:49 GMT 2023 , Edited by admin on Fri Dec 15 16:00:49 GMT 2023
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1356129
Created by
admin on Fri Dec 15 16:00:49 GMT 2023 , Edited by admin on Fri Dec 15 16:00:49 GMT 2023
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GKN429M9VS
Created by
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153-98-0
Created by
admin on Fri Dec 15 16:00:49 GMT 2023 , Edited by admin on Fri Dec 15 16:00:49 GMT 2023
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ACTIVE MOIETY
SUBSTANCE RECORD
