Althiazide

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C11H14ClN3O4S3
Molecular Weight	383.895
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

NS(=O)(=O)C1=CC2=C(NC(CSCC=C)NS2(=O)=O)C=C1Cl

InChI

InChIKey=VGLGVJVUHYTIIU-UHFFFAOYSA-N

InChI=1S/C11H14ClN3O4S3/c1-2-3-20-6-11-14-8-4-7(12)9(21(13,16)17)5-10(8)22(18,19)15-11/h2,4-5,11,14-15H,1,3,6H2,(H2,13,16,17)

HIDE SMILES / InChI

Description

Altizide, a thiazide diuretic, and aldosterone antagonist, in combination with spironolactone was marketed under brand name Aldactazine to treat patients with mild to moderate hypertension. In addition, Aldactazine was investigated for the treatment of congestive cardiac insufficiency.

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Thiazide-sensitive sodium-chloride cotransporter 28	Inhibitor 8,297

PubMed

PubMed

Show entries

Title	Date	PubMed
High-speed gas chromatography in doping control: fast-GC and fast-GC/MS determination of beta-adrenoceptor ligands and diuretics.	2006 Dec	17305237
A case of brucellar spondylodiscitis involving the cervical spine.	2009	20023340
Detection of urinary markers for thiazide diuretics after oral administration of hydrochlorothiazide and altizide-relevance to doping control analysis.	2009 Mar 20	19187939
Probing the allosteric modulator binding site of GluR2 with thiazide derivatives.	2009 Sep 15	19673491
Generic sample preparation combined with high-resolution liquid chromatography-time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories.	2010 Apr	20155493

Showing 1 to 5 of 5 entries

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Sample Use Guides

In Vivo Use Guide

Aldactazine ( 25 mg spironolactone and 15 mg altizide, 1/day)

Route of Administration: Oral

Show entries

Name

Type

Language

Althiazide

Official Name

English

ALTHIAZIDE [USAN]

Common Name

English

Altizide

Official Name

English

NSC-757786

Code

English

Altizide [WHO-DD]

Common Name

English

Showing 1 to 5 of 12 entries

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Show entries

Classification Tree

Code System

Code

Low-ceiling diuretics and potassium-sparing agents

WHO-VATC

QC03EA04

Diuretic

NCI_THESAURUS

C49185

Low-ceiling diuretics and potassium-sparing agents

WHO-ATC

C03EA04

Showing 1 to 3 of 3 entries

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Show entries

Code System

Code

Type

Description

EVMPD

SUB05379MIG

PRIMARY

MERCK INDEX

m1584

PRIMARY

Merck Index

PUBCHEM

2122

PRIMARY

ChEMBL

CHEMBL599870

PRIMARY

INN

1382

PRIMARY

Showing 1 to 5 of 16 entries

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ACTIVE MOIETY


					GI8CB72B0D

Althiazide