U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Description
Curator's Comment:: https://www.drugbank.ca/drugs/DB00046 | https://www.accessdata.fda.gov/drugsatfda_docs/label/1999/21017lbl.pdf

Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Chemically, insulin lispro is Lys(B28), Pro(B29) human insulin analog, created when the amino acids at positions 28 and 29 on the insulin B-chain are reversed. Insulin lispro is synthesized in a special non-pathogenic laboratory strain of Escherichia coli bacteria that has been genetically altered by the addition of the gene for insulin lispro. Regulation of glucose metabolism is the primary activity of insulins and insulin analogs, including insulin lispro products. Insulins lower blood glucose by stimulating peripheral glucose uptake by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulins inhibit lipolysis and proteolysis, and enhance protein synthesis. Insulin lispro begins to exert its effects within 15 minutes of subcutaneous administration, while peak levels occur 30 to 90 minutes after administration. Due to its duration of action of around 5 hours, Humalog is considered "bolus insulin" as it provides high levels of insulin in a short period of time to mimic the release of endogenous insulin from the pancreas after meals. Bolus insulin is often combined with once daily, long-acting "basal insulin" to provide low concentrations of background insulin that can keep blood sugar stable between meals or overnight. Use of basal and bolus insulin together is intended to mimic the pancreas' production of endogenous insulin, with a goal of avoiding any periods of hypoglycemia.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
HUMALOG MIX

Approved Use

Humalog Mix75/25, a mixture of 75% insulin lispro protamine suspension and 25% insulin lispro injection, (rDNA origin), is indicated in the treatment of patients with diabetes mellitus for the control of hyperglycemia. Humalog Mix75/25 has a more rapid onset of glucose-lowering activity compared with Humulin 70/30 while having a similar duration of action. This profile is achieved by combining the rapid onset of Humalog with the intermediate action of insulin lispro protamine suspension.

Launch Date

945734400000
Name Type Language
INSULIN LISPRO
EMA EPAR   EP   INN   MI   USAN   USP   USP-RS   WHO-DD  
USAN   INN  
Official Name English
IDENTICAL TO HUMAN INSULIN EXCEPT FOR THE TRANSPOSITION OF PROLINE AND LYSINE AT POSITIONS 28 AND 29 ON THE B CHAIN
Common Name English
INSULIN LISPRO (GENETICAL RECOMBINATION)
Common Name English
HUMALOG
Brand Name English
INSULIN LISPRO RECOMBINANT [ORANGE BOOK]
Common Name English
INSULIN LISPRO [EMA EPAR]
Common Name English
LISPRO
Common Name English
INSULIN LISPRO [INN]
Common Name English
LISPRO-PH20 COMPONENT INSULIN LISPRO
Common Name English
INSULIN LISPRO [EP MONOGRAPH]
Common Name English
INSULIN,LISPRO,PROTAMINE/RDNA
VANDF  
Common Name English
INSULIN,LISPRO,PROTAMINE/RDNA [VANDF]
Common Name English
INSULIN LISPRO RECOMBINANT
ORANGE BOOK  
Common Name English
LY900014
Code English
LISPRO INSULIN
Common Name English
ADMELOG
Brand Name English
INSULIN LISPRO (RDNA ORIGIN)
Common Name English
INSULIN B28(LYS)-B29(PRO) RECOMBINANT HUMAN/PROTAMINE SULPHATE
Common Name English
INSULIN LISPRO [USP MONOGRAPH]
Common Name English
28(SUP B)-L-LYSINE-29(SUP B)-L-PROLINEINSULIN (HUMAN)
Common Name English
INSULIN LISPRO [WHO-DD]
Common Name English
INSULIN LISPRO PROTAMINE
Common Name English
INSULIN LISPRO [USAN]
Common Name English
INSULIN LISPRO [MI]
Common Name English
INSULIN,LISPRO,HUMAN/RDNA [VANDF]
Common Name English
INSULIN LISPRO PROTAMINE SUSPENSION [WHO-DD]
Common Name English
ADMELOG SOLOSTAR
Brand Name English
INSULIN LISPRO PROTAMINE RECOMBINANT [ORANGE BOOK]
Common Name English
LY-275585
Code English
INSULIN LISPRO PROTAMINE SUSPENSION
WHO-DD  
Common Name English
SAR-342434
Code English
INSULIN LISPRO [USP-RS]
Common Name English
LY275585
Code English
SAR342434
Code English
INSULIN,LISPRO,HUMAN/RDNA
VANDF  
Common Name English
INSULIN (HUMAN), 28(SUP B)-L-LYSINE-29(SUP B)-L-PROLINE-
Common Name English
INSULIN LISPRO PROTAMINE RECOMBINANT
ORANGE BOOK  
Common Name English
LY-900014
Code English
Classification Tree Code System Code
NDF-RT N0000175453
Created by admin on Fri Jun 25 20:51:56 UTC 2021 , Edited by admin on Fri Jun 25 20:51:56 UTC 2021
NCI_THESAURUS C581
Created by admin on Fri Jun 25 20:51:56 UTC 2021 , Edited by admin on Fri Jun 25 20:51:56 UTC 2021
NDF-RT N0000004931
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WHO-ATC A10AB04
Created by admin on Fri Jun 25 20:51:56 UTC 2021 , Edited by admin on Fri Jun 25 20:51:56 UTC 2021
WHO-VATC QA10AC04
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WHO-VATC QA10AD04
Created by admin on Fri Jun 25 20:51:56 UTC 2021 , Edited by admin on Fri Jun 25 20:51:56 UTC 2021
NDF-RT N0000004931
Created by admin on Fri Jun 25 20:51:56 UTC 2021 , Edited by admin on Fri Jun 25 20:51:56 UTC 2021
WHO-VATC QA10AB04
Created by admin on Fri Jun 25 20:51:56 UTC 2021 , Edited by admin on Fri Jun 25 20:51:56 UTC 2021
WHO-ATC A10AD04
Created by admin on Fri Jun 25 20:51:56 UTC 2021 , Edited by admin on Fri Jun 25 20:51:56 UTC 2021
WHO-ATC A10AC04
Created by admin on Fri Jun 25 20:51:56 UTC 2021 , Edited by admin on Fri Jun 25 20:51:56 UTC 2021
NDF-RT N0000004931
Created by admin on Fri Jun 25 20:51:56 UTC 2021 , Edited by admin on Fri Jun 25 20:51:56 UTC 2021
Code System Code Type Description
FDA UNII
GFX7QIS1II
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PRIMARY
EVMPD
SUB128662
Created by admin on Fri Jun 25 20:51:56 UTC 2021 , Edited by admin on Fri Jun 25 20:51:56 UTC 2021
PRIMARY
ChEMBL
CHEMBL1201611
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PRIMARY
RXCUI
86009
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PRIMARY RxNorm
MERCK INDEX
M6300
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PRIMARY Merck Index
NCI_THESAURUS
C29123
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PRIMARY
PUBCHEM
118984450
Created by admin on Fri Jun 25 20:51:56 UTC 2021 , Edited by admin on Fri Jun 25 20:51:56 UTC 2021
PRIMARY
EVMPD
SUB08198MIG
Created by admin on Fri Jun 25 20:51:56 UTC 2021 , Edited by admin on Fri Jun 25 20:51:56 UTC 2021
PRIMARY
EPA CompTox
133107-64-9
Created by admin on Fri Jun 25 20:51:56 UTC 2021 , Edited by admin on Fri Jun 25 20:51:56 UTC 2021
PRIMARY
DRUG CENTRAL
5002
Created by admin on Fri Jun 25 20:51:56 UTC 2021 , Edited by admin on Fri Jun 25 20:51:56 UTC 2021
PRIMARY
MESH
D061268
Created by admin on Fri Jun 25 20:51:56 UTC 2021 , Edited by admin on Fri Jun 25 20:51:56 UTC 2021
PRIMARY
DRUG BANK
DB00046
Created by admin on Fri Jun 25 20:51:56 UTC 2021 , Edited by admin on Fri Jun 25 20:51:56 UTC 2021
PRIMARY
CAS
133107-64-9
Created by admin on Fri Jun 25 20:51:56 UTC 2021 , Edited by admin on Fri Jun 25 20:51:56 UTC 2021
PRIMARY
EVMPD
SUB128661
Created by admin on Fri Jun 25 20:51:56 UTC 2021 , Edited by admin on Fri Jun 25 20:51:56 UTC 2021
PRIMARY
USP_CATALOG
1342321
Created by admin on Fri Jun 25 20:51:56 UTC 2021 , Edited by admin on Fri Jun 25 20:51:56 UTC 2021
PRIMARY USP-RS
WIKIPEDIA
INSULIN LISPRO
Created by admin on Fri Jun 25 20:51:56 UTC 2021 , Edited by admin on Fri Jun 25 20:51:56 UTC 2021
PRIMARY
INN
7278
Created by admin on Fri Jun 25 20:51:56 UTC 2021 , Edited by admin on Fri Jun 25 20:51:56 UTC 2021
PRIMARY
ChEMBL
CHEMBL1201538
Created by admin on Fri Jun 25 20:51:56 UTC 2021 , Edited by admin on Fri Jun 25 20:51:56 UTC 2021
PRIMARY