Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C5H13NO7P2.2Na |
| Molecular Weight | 307.0863 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[Na+].CN(C)CCC(O)(P(O)([O-])=O)P(O)([O-])=O
InChI
InChIKey=JFGHPLSPUGOSLV-UHFFFAOYSA-L
InChI=1S/C5H15NO7P2.2Na/c1-6(2)4-3-5(7,14(8,9)10)15(11,12)13;;/h7H,3-4H2,1-2H3,(H2,8,9,10)(H2,11,12,13);;/q;2*+1/p-2
Olpadronate, a nitrogenated bisphosphonate that can inhibit bone resorption. Although it shares the therapeutic and pharmacological properties of pamidronate and alendronate, it has a greater dosage amplitude, more predictable effects, and greater digestive tolerability than other bisphosphates. Clinical trials have shown that the oral olpadronate was well tolerated and effective in the treatment of Paget's disease. In addition, the drug is ongoing in phase II clinical trials in the Netherlands. This clinical trial has to assess the efficacy of the intravenous drug in decreasing the average back pain intensity from baseline.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Interventions for Improving Bone Mineral Density and Reducing Fracture Risk in Osteogenesis Imperfecta: A Mixed Treatment Comparison Network Meta-analysis of Randomized Controlled Clinical Trials. | 2018 |
|
| Bisphosphonates for Paget's disease of bone in adults. | 2017-12-01 |
|
| [Treatment of Paget's disease with olpadronate. Its efficacy in partial responders to oral pamidronate]. | 1997 |
Sample Use Guides
Paget's disease: olpadronate was given orally in doses of 100 to 200 mg/day. Initial dose and/or increment of the dose during treatment were decided accordingly to the biochemical response
Olpadronate intra venous in chronic low back pain: 20 mg and 40 mg
Route of Administration:
Other
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DTXSID30153250
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121368-58-9
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G90M9V9GMQ
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198715
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admin on Mon Mar 31 18:56:37 GMT 2025 , Edited by admin on Mon Mar 31 18:56:37 GMT 2025
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PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
