Details
Stereochemistry | ACHIRAL |
Molecular Formula | C16H21N4O3.Na |
Molecular Weight | 340.3527 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].CCCC1=C(O)C(=CC=C1OCCCCC2=NN=N[N-]2)C(C)=O
InChI
InChIKey=WGUJPHDKJRVHMX-UHFFFAOYSA-M
InChI=1S/C16H22N4O3.Na/c1-3-6-13-14(9-8-12(11(2)21)16(13)22)23-10-5-4-7-15-17-19-20-18-15;/h8-9H,3-7,10H2,1-2H3,(H2,17,18,19,20,21,22);/q;+1/p-1
Originator
Sources: http://adisinsight.springer.com/drugs/800000075
Curator's Comment: # Eli Lilly
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: Q9Y271 Gene ID: 10800.0 Gene Symbol: CYSLTR1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/3981452 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2554766 |
Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
---|---|---|
In vivo characterization of zymosan-induced mouse peritoneal inflammation. | 1994 Jun |
|
Enhanced activity of Ca2+-activated K+ channels by 1-[2-hydroxy-3-propyl-4-[(1H-tetrazol-5-yl)butoxyl]phenyl] ethanone (LY-171883) in neuroendocrine and neuroblastoma cell lines. | 2002 Aug |
|
Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13. | 2003 Apr |
|
Actions of cysteinyl leukotrienes in the enteric nervous system of guinea-pig stomach and small intestine. | 2003 Jan 10 |
|
Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro. | 2004 Oct |
|
Molecular basis for reduced estrone sulfate transport and altered modulator sensitivity of transmembrane helix (TM) 6 and TM17 mutants of multidrug resistance protein 1 (ABCC1). | 2009 Jul |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2554766
600 mg twice daily for 6 weeks
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1706765
LY171883 functioned primarily as a leukotriene receptor antagonist with minimal pharmacological activity attributable to its ability to potentiate isoprenaline. Relaxation of carbachol-contracted guinea-pig trachea by isoprenaline was enhanced by the three agents in a dose-dependent manner. A two-fold enhancement of isoprenaline-induced smooth muscle relaxation was produced by 2.5 microM IBMX, 28 microM LY171883, or 140 microM theophylline. LY171883 totally inhibited the response and had significant LTE4 receptor antagonist activity even at 10-fold lower concentrations.
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
162623868
Created by
admin on Fri Dec 15 15:13:53 UTC 2023 , Edited by admin on Fri Dec 15 15:13:53 UTC 2023
|
PRIMARY | |||
|
G4YL9T9SOU
Created by
admin on Fri Dec 15 15:13:53 UTC 2023 , Edited by admin on Fri Dec 15 15:13:53 UTC 2023
|
PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD