IODOHIPPURIC ACID I-123

US Previously Marketed

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H8INO3
Molecular Weight	301.0703
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)CNC(=O)C1=CC=CC=C1[123I]

InChI

InChIKey=CORFWQGVBFFZHF-YWNMBFHISA-N

InChI=1S/C9H8INO3/c10-7-4-2-1-3-6(7)9(14)11-5-8(12)13/h1-4H,5H2,(H,11,14)(H,12,13)/i10-4

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10987332
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/6485965 | https://www.ncbi.nlm.nih.gov/pubmed/6492475 | https://www.ncbi.nlm.nih.gov/pubmed/3680968 | https://www.ncbi.nlm.nih.gov/pubmed/2208882 | https://www.ncbi.nlm.nih.gov/pubmed/8767955 | https://www.ncbi.nlm.nih.gov/pubmed/8827809 | https://www.ncbi.nlm.nih.gov/pubmed/6677098

I-123 radiolabeled ortho-iodohippurate is commonly employed for evaluating effective renal plasma flow (ERPF) by means of either in vivo scintigraphy and/or plasma clearance curves. It has been used to evaluate renal functioning in patients with obstructive uropathy, vesicorenal reflux, hypertensiion due to renal artery stenosis.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
renal filtration 2 Target ID: GO:0097205 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10987332 \| https://www.ncbi.nlm.nih.gov/pubmed/9814418 \| https://www.ncbi.nlm.nih.gov/pubmed/8827809 \| https://www.ncbi.nlm.nih.gov/pubmed/8767955	Interacts 323

Conditions

Condition	Modality	Targets	Highest Phase	Product
Renal failure 9 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6485965 https://www.ncbi.nlm.nih.gov/pubmed/6492475 https://www.ncbi.nlm.nih.gov/pubmed/3680968 https://www.ncbi.nlm.nih.gov/pubmed/2208882 https://www.ncbi.nlm.nih.gov/pubmed/8767955 https://www.ncbi.nlm.nih.gov/pubmed/8827809 https://www.ncbi.nlm.nih.gov/pubmed/6677098	Diagnostic		Withdrawn	IODOHIPPURATE SODIUM I-123 Approved Use Unknown Launch Date 4.72953586E11

PubMed

Title	Date	PubMed
Renal clearance and extraction parameters of ortho-iodohippurate (I-123) compared with OIH(I-131) and PAH.	1980 Feb	7356755
Posture-induced disturbance of pertechnetate flow and I-123 iodohippurate transport in some renal graft recipients with hypertension.	1980 Sep	6997440
[Regional renogram and functional imaging with I-123-orthoiodohippurate in obstructive nephropathy].	1983 Nov	6677098
[Dynamic urinary flow images in patients with ileal loop diversion assessed by I-123-hippuran scintigraphy. Detection of ileoureteral reflux].	1984 Jun	6485965
[Age and sex dependence of tubular kidney clearance in childhood].	1984 Oct 25	6500461
A simplified method for the routine determination of effective renal plasma flow.	1986 Nov	3791782
[The course of renal function in vesicorenal reflux. Study using I-123 Hippuran].	1987	3680968
Diminished response to furosemide in I-123 Hippuran renal studies of renovascular hypertension caused by unilateral renal artery stenosis.	1990 Sep	2208882
Comparison of scintigraphic renal differentials using radiolabeled orthoiodohippurate and glucoheptonate.	1991 Jun	1868647
[Mean renal transit time of I-123 orthoiodohippurate in normotensive and hypertensive subjects].	1996 Jan-Feb	8767955
Measurement of effective renal plasma flow (ERPF) with 123I-orthoiodohippurate (I-123-OIH).	1996 May-Jun	8827809
Modification of measurement of effective renal plasma flow from blood pool clearance curve of I-123-orthoiodohippurate using single blood sampling.	1998 Jul-Aug	9814418
Evaluation of effective renal plasma flow with I-127 ortho-iodohippurate and I-123 ortho-iodohippurate in rabbits.	2000 Sep	10987332

Patents

Sample Use Guides

In Vivo Use Guide

After 1 mCi of I-123- orthoiodohippurate was given intravenously, serial renal scintigrams were obtained for 25 minutes and regional renogram curves were derived from the whole kidney, the cortical and pelvic areas.

Route of Administration: Intravenous

In Vitro Use Guide

Unknown

Name

Type

Language

IODOHIPPURIC ACID I-123

Common Name

English

GLYCINE, N-(2-(IODO-123I)BENZOYL)-

Common Name

English

O-IODOHIPPURIC-123I ACID

Common Name

English

O-IODOHIPPURIC ACID, I-123

Common Name

English

O-IODOHIPPURIC ACID I-123

Common Name

English

Classification Tree Code System Code

WHO-ATC

V09CX01