IODOHIPPURIC ACID I-123

US Previously Marketed

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H8INO3
Molecular Weight	301.0703
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)CNC(=O)C1=CC=CC=C1[123I]

InChI

InChIKey=CORFWQGVBFFZHF-YWNMBFHISA-N

InChI=1S/C9H8INO3/c10-7-4-2-1-3-6(7)9(14)11-5-8(12)13/h1-4H,5H2,(H,11,14)(H,12,13)/i10-4

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10987332
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/6485965 | https://www.ncbi.nlm.nih.gov/pubmed/6492475 | https://www.ncbi.nlm.nih.gov/pubmed/3680968 | https://www.ncbi.nlm.nih.gov/pubmed/2208882 | https://www.ncbi.nlm.nih.gov/pubmed/8767955 | https://www.ncbi.nlm.nih.gov/pubmed/8827809 | https://www.ncbi.nlm.nih.gov/pubmed/6677098

I-123 radiolabeled ortho-iodohippurate is commonly employed for evaluating effective renal plasma flow (ERPF) by means of either in vivo scintigraphy and/or plasma clearance curves. It has been used to evaluate renal functioning in patients with obstructive uropathy, vesicorenal reflux, hypertensiion due to renal artery stenosis.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
renal filtration 2 Target ID: GO:0097205 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10987332 \| https://www.ncbi.nlm.nih.gov/pubmed/9814418 \| https://www.ncbi.nlm.nih.gov/pubmed/8827809 \| https://www.ncbi.nlm.nih.gov/pubmed/8767955	Interacts 323

Conditions

Condition	Modality	Targets	Highest Phase	Product
Renal failure 9 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6485965 https://www.ncbi.nlm.nih.gov/pubmed/6492475 https://www.ncbi.nlm.nih.gov/pubmed/3680968 https://www.ncbi.nlm.nih.gov/pubmed/2208882 https://www.ncbi.nlm.nih.gov/pubmed/8767955 https://www.ncbi.nlm.nih.gov/pubmed/8827809 https://www.ncbi.nlm.nih.gov/pubmed/6677098	Diagnostic		Withdrawn	IODOHIPPURATE SODIUM I-123 Approved Use Unknown Launch Date 1984

PubMed

Title	Date	PubMed
Evaluation of effective renal plasma flow with I-127 ortho-iodohippurate and I-123 ortho-iodohippurate in rabbits.	2000 Sep	10987332

Patents

Sample Use Guides

In Vivo Use Guide

After 1 mCi of I-123- orthoiodohippurate was given intravenously, serial renal scintigrams were obtained for 25 minutes and regional renogram curves were derived from the whole kidney, the cortical and pelvic areas.

Route of Administration: Intravenous

In Vitro Use Guide

Unknown

Name

Type

Language

IODOHIPPURIC ACID I-123

Common Name

English

GLYCINE, N-(2-(IODO-123I)BENZOYL)-

Common Name

English

O-IODOHIPPURIC-123I ACID

Common Name

English

O-IODOHIPPURIC ACID, I-123

Common Name

English

O-IODOHIPPURIC ACID I-123

Common Name

English

Classification Tree Code System Code

WHO-ATC

V09CX01