IODOHIPPURATE SODIUM I-123

US Previously Marketed

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H7INO3.Na
Molecular Weight	323.0521
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[O-]C(=O)CNC(=O)C1=CC=CC=C1[123I]

InChI

InChIKey=XYITYKDGJLHYPW-TWDNZPFZSA-M

InChI=1S/C9H8INO3.Na/c10-7-4-2-1-3-6(7)9(14)11-5-8(12)13;/h1-4H,5H2,(H,11,14)(H,12,13);/q;+1/p-1/i10-4;

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.98976928
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C9H7INO3
Molecular Weight	300.0624
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10987332
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/6485965 | https://www.ncbi.nlm.nih.gov/pubmed/6492475 | https://www.ncbi.nlm.nih.gov/pubmed/3680968 | https://www.ncbi.nlm.nih.gov/pubmed/2208882 | https://www.ncbi.nlm.nih.gov/pubmed/8767955 | https://www.ncbi.nlm.nih.gov/pubmed/8827809 | https://www.ncbi.nlm.nih.gov/pubmed/6677098

I-123 radiolabeled ortho-iodohippurate is commonly employed for evaluating effective renal plasma flow (ERPF) by means of either in vivo scintigraphy and/or plasma clearance curves. It has been used to evaluate renal functioning in patients with obstructive uropathy, vesicorenal reflux, hypertensiion due to renal artery stenosis.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
renal filtration 2 Target ID: GO:0097205 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10987332 \| https://www.ncbi.nlm.nih.gov/pubmed/9814418 \| https://www.ncbi.nlm.nih.gov/pubmed/8827809 \| https://www.ncbi.nlm.nih.gov/pubmed/8767955	Interacts 323

Conditions

Condition	Modality	Targets	Highest Phase	Product
Renal failure 9 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6485965 https://www.ncbi.nlm.nih.gov/pubmed/6492475 https://www.ncbi.nlm.nih.gov/pubmed/3680968 https://www.ncbi.nlm.nih.gov/pubmed/2208882 https://www.ncbi.nlm.nih.gov/pubmed/8767955 https://www.ncbi.nlm.nih.gov/pubmed/8827809 https://www.ncbi.nlm.nih.gov/pubmed/6677098	Diagnostic		Withdrawn	IODOHIPPURATE SODIUM I-123 Approved Use Unknown Launch Date 1984

PubMed

Title	Date	PubMed
Evaluation of effective renal plasma flow with I-127 ortho-iodohippurate and I-123 ortho-iodohippurate in rabbits.	2000-09	10987332
Modification of measurement of effective renal plasma flow from blood pool clearance curve of I-123-orthoiodohippurate using single blood sampling.	1998-11-14	9814418
Measurement of effective renal plasma flow (ERPF) with 123I-orthoiodohippurate (I-123-OIH).	1996-05-01	8827809
[Mean renal transit time of I-123 orthoiodohippurate in normotensive and hypertensive subjects].	1996-01-01	8767955
Comparison of scintigraphic renal differentials using radiolabeled orthoiodohippurate and glucoheptonate.	1991-06	1868647
Diminished response to furosemide in I-123 Hippuran renal studies of renovascular hypertension caused by unilateral renal artery stenosis.	1990-09	2208882
[The course of renal function in vesicorenal reflux. Study using I-123 Hippuran].	1987	3680968
A simplified method for the routine determination of effective renal plasma flow.	1986-11	3791782
[Age and sex dependence of tubular kidney clearance in childhood].	1984-10-25	6500461
[Dynamic urinary flow images in patients with ileal loop diversion assessed by I-123-hippuran scintigraphy. Detection of ileoureteral reflux].	1984-06	6485965
[Regional renogram and functional imaging with I-123-orthoiodohippurate in obstructive nephropathy].	1983-11	6677098
Posture-induced disturbance of pertechnetate flow and I-123 iodohippurate transport in some renal graft recipients with hypertension.	1980-09	6997440
Renal clearance and extraction parameters of ortho-iodohippurate (I-123) compared with OIH(I-131) and PAH.	1980-02	7356755

Patents

Sample Use Guides

In Vivo Use Guide

After 1 mCi of I-123- orthoiodohippurate was given intravenously, serial renal scintigrams were obtained for 25 minutes and regional renogram curves were derived from the whole kidney, the cortical and pelvic areas.

Route of Administration: Intravenous

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:54:54 GMT 2025` Edited by `admin` on `Mon Mar 31 17:54:54 GMT 2025`
Record UNII	4NW20GFQ7H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IODOHIPPURATE SODIUM I 123

Preferred Name

English

IODOHIPPURATE SODIUM I-123

Common Name

English

GLYCINE, N-(2-(IODO-(SUP 123)I) BENZOYL)-, MONOSODIUM SALT

Common Name

English

O-IODOHIPPURATE SODIUM 123I-LABELED FORM [MI]

Common Name

English

IODOHIPPURATE SODIUM I-123 [ORANGE BOOK]

Common Name

English

SODIUM IODOHIPPURATE (123 I)

Common Name

English

IODOHIPPURATE SODIUM I 123 [USP IMPURITY]

Common Name

English

IODOHIPPURATE SODIUM, I-123

Common Name

English

Sodium iodohippurate (123 i) [WHO-DD]

Common Name

English

IODOHIPPURATE SODIUM I 123 [USAN]

Common Name

English

SODIUM IODOHIPPURATE (123-I)

Common Name

English

IODOHIPPURATE SODIUM,I-123 [VANDF]

Common Name

English

O-IODOHIPPURATE SODIUM 123I-LABELED FORM

Common Name

English

IODOHIPPURATE SODIUM,I-123

Common Name

English

IODOHIPPURATE I123 SODIUM

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2124