IODOHIPPURATE SODIUM I-123

US Previously Marketed

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H7INO3.Na
Molecular Weight	323.0521
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[O-]C(=O)CNC(=O)C1=CC=CC=C1[123I]

InChI

InChIKey=XYITYKDGJLHYPW-TWDNZPFZSA-M

InChI=1S/C9H8INO3.Na/c10-7-4-2-1-3-6(7)9(14)11-5-8(12)13;/h1-4H,5H2,(H,11,14)(H,12,13);/q;+1/p-1/i10-4;

HIDE SMILES / InChI

Molecular Formula	C9H7INO3
Molecular Weight	300.0624
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10987332
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/6485965 | https://www.ncbi.nlm.nih.gov/pubmed/6492475 | https://www.ncbi.nlm.nih.gov/pubmed/3680968 | https://www.ncbi.nlm.nih.gov/pubmed/2208882 | https://www.ncbi.nlm.nih.gov/pubmed/8767955 | https://www.ncbi.nlm.nih.gov/pubmed/8827809 | https://www.ncbi.nlm.nih.gov/pubmed/6677098

I-123 radiolabeled ortho-iodohippurate is commonly employed for evaluating effective renal plasma flow (ERPF) by means of either in vivo scintigraphy and/or plasma clearance curves. It has been used to evaluate renal functioning in patients with obstructive uropathy, vesicorenal reflux, hypertensiion due to renal artery stenosis.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
renal filtration 2 Target ID: GO:0097205 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10987332 \| https://www.ncbi.nlm.nih.gov/pubmed/9814418 \| https://www.ncbi.nlm.nih.gov/pubmed/8827809 \| https://www.ncbi.nlm.nih.gov/pubmed/8767955	Interacts 323

Conditions

Condition	Modality	Targets	Highest Phase	Product
Renal failure 9 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6485965 https://www.ncbi.nlm.nih.gov/pubmed/6492475 https://www.ncbi.nlm.nih.gov/pubmed/3680968 https://www.ncbi.nlm.nih.gov/pubmed/2208882 https://www.ncbi.nlm.nih.gov/pubmed/8767955 https://www.ncbi.nlm.nih.gov/pubmed/8827809 https://www.ncbi.nlm.nih.gov/pubmed/6677098	Diagnostic		Withdrawn	IODOHIPPURATE SODIUM I-123 Approved Use Unknown Launch Date 1984

PubMed

Title	Date	PubMed
[Age and sex dependence of tubular kidney clearance in childhood].	1984 Oct 25	6500461
A simplified method for the routine determination of effective renal plasma flow.	1986 Nov	3791782
Diminished response to furosemide in I-123 Hippuran renal studies of renovascular hypertension caused by unilateral renal artery stenosis.	1990 Sep	2208882
Comparison of scintigraphic renal differentials using radiolabeled orthoiodohippurate and glucoheptonate.	1991 Jun	1868647
[Mean renal transit time of I-123 orthoiodohippurate in normotensive and hypertensive subjects].	1996 Jan-Feb	8767955
Measurement of effective renal plasma flow (ERPF) with 123I-orthoiodohippurate (I-123-OIH).	1996 May-Jun	8827809
Modification of measurement of effective renal plasma flow from blood pool clearance curve of I-123-orthoiodohippurate using single blood sampling.	1998 Jul-Aug	9814418
Evaluation of effective renal plasma flow with I-127 ortho-iodohippurate and I-123 ortho-iodohippurate in rabbits.	2000 Sep	10987332

Patents

Sample Use Guides

In Vivo Use Guide

After 1 mCi of I-123- orthoiodohippurate was given intravenously, serial renal scintigrams were obtained for 25 minutes and regional renogram curves were derived from the whole kidney, the cortical and pelvic areas.

Route of Administration: Intravenous

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:21:06 GMT 2023` Edited by `admin` on `Fri Dec 15 15:21:06 GMT 2023`
Record UNII	4NW20GFQ7H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IODOHIPPURATE SODIUM I-123

Common Name

English

IODOHIPPURATE SODIUM I 123

Official Name

English

GLYCINE, N-(2-(IODO-(SUP 123)I) BENZOYL)-, MONOSODIUM SALT

Common Name

English

O-IODOHIPPURATE SODIUM 123I-LABELED FORM [MI]

Common Name

English

IODOHIPPURATE SODIUM I-123 [ORANGE BOOK]

Common Name

English

SODIUM IODOHIPPURATE (123 I)

Common Name

English

IODOHIPPURATE SODIUM I 123 [USP IMPURITY]

Common Name

English

IODOHIPPURATE SODIUM, I-123

Common Name

English

Sodium iodohippurate (123 i) [WHO-DD]

Common Name

English

IODOHIPPURATE SODIUM I 123 [USAN]

Common Name

English

SODIUM IODOHIPPURATE (123-I)

Common Name

English

IODOHIPPURATE SODIUM,I-123 [VANDF]

Common Name

English

O-IODOHIPPURATE SODIUM 123I-LABELED FORM

Common Name

English

IODOHIPPURATE SODIUM,I-123

Common Name

English

IODOHIPPURATE I123 SODIUM

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2124