CAMPHENE

Details

Stereochemistry	MIXED
Molecular Formula	C10H16
Molecular Weight	136.234
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1(C)C2CCC(C2)C1=C

InChI

InChIKey=CRPUJAZIXJMDBK-UHFFFAOYSA-N

InChI=1S/C10H16/c1-7-8-4-5-9(6-8)10(7,2)3/h8-9H,1,4-6H2,2-3H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26784701 | https://www.ncbi.nlm.nih.gov/pubmed/26471302

Camphene is a bicyclic monoterpene, a Plant Derived Monoterpene, which possessed antitumor activity. This was found in vivo by inhibiting subcutaneous tumor growth of highly aggressive melanoma cells in a syngeneic model, suggesting a promising role of this compound in cancer therapy. In addition was shown, that camphene lowered cholesterol and triglycerides (TG) in the plasma of hyperlipidemic rats without affecting HMG-CoA reductase activity. And was suggested, that camphene upregulated Sterol regulatory element-binding proteins (SREBP-1) expression and microsomal triglyceride transfer protein (MTP) inhibition was likely to be a probable mechanism whereby camphene exerts its hypolipidemic effect.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Sterol regulatory element-binding protein 1 2 Target ID: P36956\|\|\|Q6PJ36 Gene ID: 6720.0 Gene Symbol: SREBF1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/26784701	Activator 1430
Microsomal triglyceride transfer protein large subunit 4 Target ID: P55157 Gene ID: 4547.0 Gene Symbol: MTTP Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/26784701	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Melanoma 88 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26471302	Primary		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
(M)VOC and composting facilities. Part 2: (M)VOC dispersal in the environment.	2004	15259697
The effect of selected monoterpenoids on the cellular slime mold, Dictyostelium discoideum NC4.	2004 Jun	15303320
Essential oil of Valeriana officinalis L. cultivars and their antimicrobial activity as influenced by harvesting time under commercial organic cultivation.	2004 Jun 16	15186117
Chemical composition and antimicrobial activity of the essential oils from the gum of Turkish pistachio (Pistacia vera L.).	2004 Jun 16	15186116
Full-scale chamber investigation and simulation of air freshener emissions in the presence of ozone.	2004 May 15	15212253
Main compounds responsible for off-odour of strawberries infected by Phytophthora cactorum.	2005	15752214
Application of artificial neural network on mono- and sesquiterpenes compounds determined by headspace solid-phase microextraction-gas chromatography-mass spectrometry for the Piedmont ricotta cheese traceability.	2005 Apr 15	15865200
Changes in anatomy and terpene chemistry in roots of Douglas-fir seedlings following treatment with methyl jasmonate.	2005 Aug	15929938
Improving pulse sequences for 3D DOSY: convection compensation.	2005 Dec	16140552
Gas chromatography-mass spectrometry study of the essential oils of Schinus longifolia (Lindl.) speg., Schinus fasciculata (Griseb.) I. M. Johnst., and Schinus areira L.	2005 Jan-Feb	15787239
How rainfall, relative humidity and temperature influence volatile emissions from apple trees in situ.	2005 Jul	15949824
An experimental study of sexual function improving effect of Myristica fragrans Houtt. (nutmeg).	2005 Jul 20	16033651
Analysis of aroma and phenolic components of selected Achillea species.	2005 Jun	16021832
Identification of an EcoRI restriction site for a rapid and precise determination of beta-asarone-free Acorus calamus cytotypes.	2005 Mar	15721942
Characteristic odor components of kumquat (Fortunella japonica Swingle) peel oil.	2005 Mar 9	15740053
Allelopathic effects of volatile monoterpenoids produced by Salvia leucophylla: Inhibition of cell proliferation and DNA synthesis in the root apical meristem of Brassica campestris seedlings.	2005 May	16124241
Measurements of biogenic hydrocarbons and carbonyl compounds emitted by trees from temperate warm Atlantic rainforest, Brazil.	2005 May	15877172
Anticonflict effects of lavender oil and identification of its active constituents.	2006 Dec	17173962
Biogenic volatile organic compounds (BVOCs) emissions from Abies alba in a French forest.	2006 Feb 1	16140360
Establishing a chromium-reactor design for measuring delta2H values of solid polyhalogenated compounds using direct elemental analysis and stable isotope ratio mass spectrometry.	2006 Jan	16283262
Chemical composition and biological activities of essential oil from the leaves of Sesuvium portulacastrum.	2006 Jan 3	16243465
Gitksan medicinal plants--cultural choice and efficacy.	2006 Jun 21	16790066
Maternal food provisioning in relation to condition-dependent offspring odours in burrower bugs (Sehirus cinctus).	2006 Jun 22	16777747
Difference in the volatile composition of pine-mushrooms (Tricholoma matsutake Sing.) according to their grades.	2006 Jun 28	16787034
[Analysis of volatile constituents in leaves of three cypress species by gas chromatography/mass spectrometry].	2006 Mar	16830472
Women's health among the Chumash.	2006 Mar	16550233
Synthesis of low and high chlorinated toxaphene and comparison of their toxicity by zebrafish (Danio rerio) embryo test.	2006 Nov	17089711
Volatile organic compounds of Angelica gigas Nakai, Korean medicinal herb.	2007 Mar	17365718
The formation of ultra-fine particles during ozone-initiated oxidations with terpenes emitted from natural paint.	2007 Mar 6	16908097
Volatile chemical constituents of Piper aduncum L and Piper gibbilimbum C. DC (Piperaceae) from Papua New Guinea.	2007 Mar 9	17851397
Bimolecular and unimolecular contributions to the disparate self-chemical ionizations of alpha-pinene and camphene isomers.	2007 Nov	17920928
Variability of the needle essential oils of Pinus peuce from different populations in Montenegro and Serbia.	2008 Jul	18649304
[Analysis of volatile oil in pre and post processed pieces of Eriobotrya japonica by GC-MS].	2008 Nov	19260269
The essential oil qualitative and quantitative composition in the needles of Pinus sylvestris L. growing along industrial transects.	2008 Oct	18372084
Antinociceptive effect and GC/MS analysis of Rosmarinus officinalis L. essential oil from its aerial parts.	2009 Apr	19184968
Fingerprint of selected Salvia species by HS-GC-MS analysis of their volatile fraction.	2009 Aug	19772730
Temperature-dependent release of volatile organic compounds of eucalypts by direct analysis in real time (DART) mass spectrometry.	2009 Aug	19551840
Rosmarinus officinalis L.: chemical modifications of the essential oil and evaluation of antioxidant and antimicrobial activity.	2009 Dec	20120107
Chemical composition of hydrodistilled essential oil of Artemisia incana (L.) Druce and antimicrobial activity against foodborne microorganisms.	2009 Dec	20020464
Essential oil variability in natural populations of Picea omorika, a rare European conifer.	2009 Feb	19235161
Comparative analysis of essential oils from eight herbal medicines with pungent flavor and cool nature by GC-MS and chemometric resolution methods.	2009 Feb	19212980
Formation and stability of secondary ozonides from monoterpenes studied by mass spectrometry.	2009 Jul	19329138
Tissue engineering polymeric microcarriers with macroporous morphology and bone-bioactive surface.	2009 Jul 7	19226560
Terpenoid emissions from Quercus robur. A case study of Galicia (NW Spain).	2009 Jun	19513459
Preparation of porous bioactive ceramic microspheres and in vitro osteoblastic culturing for tissue engineering application.	2009 Jun	19141374
Fumigant and contact toxicities of monoterpenes to Sitophilus oryzae (L.) and Tribolium castaneum (Herbst) and their inhibitory effects on acetylcholinesterase activity.	2009 May	19412756
Influence of growth phase and geographic origin on the essential oil composition of Pituranthos chloranthus from Tunisia.	2009 Nov	19967997
Multiple ultrafast, broadband 2D NMR spectra of hyperpolarized natural products.	2009 Oct 7	19743849
Comparative chemical composition and antiproliferative activity of aerial parts of Salvia leriifolia Benth. and Salvia acetabulosa L. essential oils against human tumor cell in vitro models.	2010 Feb	20136437
Cannabinoid receptor 1 binding activity and quantitative analysis of Cannabis sativa L. smoke and vapor.	2010 Feb	20118579

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Other

In Vitro Use Guide

Unknown

Name

Type

Language

CAMPHENE

Official Name

English

CAMPHENE [FCC]

Common Name

English

2,2-DIMETHYL-3-METHYLENENORBORNANE

Systematic Name

English

CAMPHENE, D,L-

Common Name

English

CAMPHENE [HSDB]

Common Name

English

Camphene [WHO-DD]

Common Name

English

CAMPHENE, (±)-

Systematic Name

English

CAMPHENE, DL-

Common Name

English

CAMPHENE [MI]

Common Name

English

NSC-4165

Code

English

CAMPHENE [INCI]

Common Name

English

CAMPHENE [MART.]

Common Name

English

DL-CAMPHENE

Common Name

English

FEMA NO. 2229

Code

English

CAMPHENE [FHFI]

Common Name

English

(±)-CAMPHENE

Systematic Name

English

BICYCLO(2.2.1)HEPTANE, 2,2-DIMETHYL-3-METHYLENE-

Systematic Name

English

Classification Tree Code System Code

CFR

21 CFR 172.515