Details
| Stereochemistry | MIXED |
| Molecular Formula | C10H16 |
| Molecular Weight | 136.234 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 0 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1(C)C2CCC(C2)C1=C
InChI
InChIKey=CRPUJAZIXJMDBK-UHFFFAOYSA-N
InChI=1S/C10H16/c1-7-8-4-5-9(6-8)10(7,2)3/h8-9H,1,4-6H2,2-3H3
| Molecular Formula | C10H16 |
| Molecular Weight | 136.234 |
| Charge | 0 |
| Count |
|
| Stereochemistry | MIXED |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Camphene is a bicyclic monoterpene, a Plant Derived Monoterpene, which possessed antitumor activity. This was found in vivo by inhibiting subcutaneous tumor growth of highly aggressive melanoma cells in a syngeneic model, suggesting a promising role of this compound in cancer therapy. In addition was shown, that camphene lowered cholesterol and triglycerides (TG) in the plasma of hyperlipidemic rats without affecting HMG-CoA reductase activity. And was suggested, that camphene upregulated Sterol regulatory element-binding proteins (SREBP-1) expression and microsomal triglyceride transfer protein (MTP) inhibition was likely to be a probable mechanism whereby camphene exerts its hypolipidemic effect.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: P36956|||Q6PJ36 Gene ID: 6720.0 Gene Symbol: SREBF1 Target Organism: Homo sapiens (Human) |
|||
Target ID: P55157 Gene ID: 4547.0 Gene Symbol: MTTP Target Organism: Homo sapiens (Human) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Attempt to unravel the composition of toxaphene by comprehensive two-dimensional gas chromatography with selective detection. | 2003 Apr 25 |
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| Supercritical carbon dioxide extraction of essential oils from Perovskia atriplicifolia Benth. | 2003 Aug 27 |
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| Chemical composition and antibacterial activity of essential oil of Artemisia iwayomogi. | 2003 Dec |
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| Antioxidative properties of the essential oil from Pinus mugo. | 2003 Dec 17 |
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| Processing DOSY spectra using the regularized resolvent transform. | 2003 Jul |
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| Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L) Merr. & Perry. (clove) in male mice: a comparative study. | 2003 Oct 20 |
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| The effect of selected monoterpenoids on the cellular slime mold, Dictyostelium discoideum NC4. | 2004 Jun |
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| Essential oil of Valeriana officinalis L. cultivars and their antimicrobial activity as influenced by harvesting time under commercial organic cultivation. | 2004 Jun 16 |
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| Full-scale chamber investigation and simulation of air freshener emissions in the presence of ozone. | 2004 May 15 |
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| Improving pulse sequences for 3D DOSY: convection compensation. | 2005 Dec |
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| Identification of an EcoRI restriction site for a rapid and precise determination of beta-asarone-free Acorus calamus cytotypes. | 2005 Mar |
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| Characteristic odor components of kumquat (Fortunella japonica Swingle) peel oil. | 2005 Mar 9 |
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| Allelopathic effects of volatile monoterpenoids produced by Salvia leucophylla: Inhibition of cell proliferation and DNA synthesis in the root apical meristem of Brassica campestris seedlings. | 2005 May |
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| Establishing a chromium-reactor design for measuring delta2H values of solid polyhalogenated compounds using direct elemental analysis and stable isotope ratio mass spectrometry. | 2006 Jan |
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| Chemical composition and biological activities of essential oil from the leaves of Sesuvium portulacastrum. | 2006 Jan 3 |
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| Gitksan medicinal plants--cultural choice and efficacy. | 2006 Jun 21 |
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| Difference in the volatile composition of pine-mushrooms (Tricholoma matsutake Sing.) according to their grades. | 2006 Jun 28 |
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| [Analysis of volatile constituents in leaves of three cypress species by gas chromatography/mass spectrometry]. | 2006 Mar |
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| Women's health among the Chumash. | 2006 Mar |
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| Synthesis of low and high chlorinated toxaphene and comparison of their toxicity by zebrafish (Danio rerio) embryo test. | 2006 Nov |
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| Baseline isotopic data of polyhalogenated compounds. | 2006 Sep 8 |
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| Chemical compositions of the essential oils of stems, leaves and flowers of Prangos acaulis (Dc) Bornm. | 2007 Aug 15 |
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| Chemical composition of the essential oil of Pelargonium quercetorum Agnew. of Iran. | 2007 Jan |
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| Volatile organic compounds of Angelica gigas Nakai, Korean medicinal herb. | 2007 Mar |
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| Assessment and implications of intraspecific and phenological variability in monoterpenes of Scots pine (Pinus sylvestris) foliage. | 2007 Mar |
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| Analysis by gas chromatography-mass spectrometry of essential oil from seeds and aerial parts of Ferulago angulata (Schlecht.) Boiss gathered in Nevakoh and Shahoo, Zagross mountain, West of Iran. | 2007 Mar 1 |
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| Volatile chemical constituents of Piper aduncum L and Piper gibbilimbum C. DC (Piperaceae) from Papua New Guinea. | 2007 Mar 9 |
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| Variability of the needle essential oils of Pinus heldreichii from different populations in Montenegro and Serbia. | 2007 May |
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| Bimolecular and unimolecular contributions to the disparate self-chemical ionizations of alpha-pinene and camphene isomers. | 2007 Nov |
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| Anti-inflammation activity of fruit essential oil from Cinnamomum insularimontanum Hayata. | 2008 Dec |
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| The oil-dispersion bath in anthroposophic medicine--an integrative review. | 2008 Dec 4 |
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| Variability of the needle essential oils of Pinus peuce from different populations in Montenegro and Serbia. | 2008 Jul |
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| Effects of cis-beta-ocimene, cis-sabinene hydrate, and monoterpene and sesquiterpene mixtures on alfalfa pellet intake by lambs. | 2008 Jun |
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| Chemical composition and antimicrobial activity of essential oil from cones of Pinus koraiensis. | 2008 Mar |
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| [Analysis of volatile oil in pre and post processed pieces of Eriobotrya japonica by GC-MS]. | 2008 Nov |
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| The essential oil qualitative and quantitative composition in the needles of Pinus sylvestris L. growing along industrial transects. | 2008 Oct |
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| Comparative analysis of chemical compositions and antimicrobial activities of essential oils from Abies holophylla and Abies koreana activities of essential oils from Abies holophylla and Abies koreana. | 2009 Apr |
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| Fingerprint of selected Salvia species by HS-GC-MS analysis of their volatile fraction. | 2009 Aug |
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| Rosmarinus officinalis L.: chemical modifications of the essential oil and evaluation of antioxidant and antimicrobial activity. | 2009 Dec |
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| Essential oil variability in natural populations of Picea omorika, a rare European conifer. | 2009 Feb |
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| Formation and stability of secondary ozonides from monoterpenes studied by mass spectrometry. | 2009 Jul |
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| Plant derived antioxidants - Geraniol and camphene protect rat alveolar macrophages against t-BHP induced oxidative stress. | 2009 Mar |
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| Radical Scavenging Activity of the Essential Oil of Silver Fir (Abies alba). | 2009 May |
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| Fabrication of HA/TCP scaffolds with a graded and porous structure using a camphene-based freeze-casting method. | 2009 May |
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| Effects of a thiosemicarbazide camphene derivative on Trichophyton mentagrophytes. | 2009 May 13 |
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| Influence of growth phase and geographic origin on the essential oil composition of Pituranthos chloranthus from Tunisia. | 2009 Nov |
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| Multiple ultrafast, broadband 2D NMR spectra of hyperpolarized natural products. | 2009 Oct 7 |
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| Formaldehyde in the indoor environment. | 2010 Apr 14 |
|
| Comparative chemical composition and antiproliferative activity of aerial parts of Salvia leriifolia Benth. and Salvia acetabulosa L. essential oils against human tumor cell in vitro models. | 2010 Feb |
|
| Cannabinoid receptor 1 binding activity and quantitative analysis of Cannabis sativa L. smoke and vapor. | 2010 Feb |
Patents
Sample Use Guides
In Vitro Use Guide
Curator's Comment: Camphene induced apoptosis by the intrinsic pathway in melanoma cells mainly by causing endoplasmic reticulum (ER) stress, with release of Ca(2+) together with HmgB1 and calreticulin, loss of mitochondrial membrane potential and up regulation of caspase-3 activity.
Unknown
| Substance Class |
Chemical
Created
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| Record UNII |
G3VG94Z26E
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| Record Status |
Validated (UNII)
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21 CFR 172.515
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JECFA EVALUATION |
CAMPHENE
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CAMPHENE
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| Related Record | Type | Details | ||
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PARENT -> CONSTITUENT ALWAYS PRESENT |
Monoterpene Class
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PARENT -> CONSTITUENT MAY BE PRESENT |
