Details
| Stereochemistry | MIXED |
| Molecular Formula | C10H16 |
| Molecular Weight | 136.2344 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 0 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C=C1C2CCC(C2)C1(C)C
InChI
InChIKey=CRPUJAZIXJMDBK-UHFFFAOYSA-N
InChI=1S/C10H16/c1-7-8-4-5-9(6-8)10(7,2)3/h8-9H,1,4-6H2,2-3H3
| Molecular Formula | C10H16 |
| Molecular Weight | 136.2344 |
| Charge | 0 |
| Count |
|
| Stereochemistry | MIXED |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Camphene is a bicyclic monoterpene, a Plant Derived Monoterpene, which possessed antitumor activity. This was found in vivo by inhibiting subcutaneous tumor growth of highly aggressive melanoma cells in a syngeneic model, suggesting a promising role of this compound in cancer therapy. In addition was shown, that camphene lowered cholesterol and triglycerides (TG) in the plasma of hyperlipidemic rats without affecting HMG-CoA reductase activity. And was suggested, that camphene upregulated Sterol regulatory element-binding proteins (SREBP-1) expression and microsomal triglyceride transfer protein (MTP) inhibition was likely to be a probable mechanism whereby camphene exerts its hypolipidemic effect.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: P36956|||Q6PJ36 Gene ID: 6720.0 Gene Symbol: SREBF1 Target Organism: Homo sapiens (Human) |
|||
Target ID: P55157 Gene ID: 4547.0 Gene Symbol: MTTP Target Organism: Homo sapiens (Human) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Age and space distributions of monoterpenes in fresh needles of Picea abies (L) Karst. Determined by gas chromatography-mass spectrometry. | 2001 Jul-Aug |
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| Seasonal changes in the composition of the essential oil extract of East Mediterranean sage (Salvia libanotica) and its toxicity in mice. | 2001 Oct |
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| Wet effluent diffusion denuder technique and the determination of volatile organic compounds in air. II. Monoterpenes. | 2002 Oct 11 |
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| Attempt to unravel the composition of toxaphene by comprehensive two-dimensional gas chromatography with selective detection. | 2003 Apr 25 |
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| Antioxidative properties of the essential oil from Pinus mugo. | 2003 Dec 17 |
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| Evaluation of different formulation studies on air-filled polymeric microcapsules by multivariate analysis. | 2003 May 12 |
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| (M)VOC and composting facilities. Part 2: (M)VOC dispersal in the environment. | 2004 |
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| Essential oil of Valeriana officinalis L. cultivars and their antimicrobial activity as influenced by harvesting time under commercial organic cultivation. | 2004 Jun 16 |
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| chemical composition, plant genetic differences, antimicrobial and antifungal activity investigation of the essential oil of Rosmarinus officinalis L. | 2004 Jun 2 |
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| Main compounds responsible for off-odour of strawberries infected by Phytophthora cactorum. | 2005 |
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| Application of artificial neural network on mono- and sesquiterpenes compounds determined by headspace solid-phase microextraction-gas chromatography-mass spectrometry for the Piedmont ricotta cheese traceability. | 2005 Apr 15 |
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| Improving pulse sequences for 3D DOSY: convection compensation. | 2005 Dec |
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| How rainfall, relative humidity and temperature influence volatile emissions from apple trees in situ. | 2005 Jul |
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| An experimental study of sexual function improving effect of Myristica fragrans Houtt. (nutmeg). | 2005 Jul 20 |
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| Analysis of aroma and phenolic components of selected Achillea species. | 2005 Jun |
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| Identification of an EcoRI restriction site for a rapid and precise determination of beta-asarone-free Acorus calamus cytotypes. | 2005 Mar |
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| Allelopathic effects of volatile monoterpenoids produced by Salvia leucophylla: Inhibition of cell proliferation and DNA synthesis in the root apical meristem of Brassica campestris seedlings. | 2005 May |
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| Biogenic volatile organic compounds (BVOCs) emissions from Abies alba in a French forest. | 2006 Feb 1 |
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| Gitksan medicinal plants--cultural choice and efficacy. | 2006 Jun 21 |
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| Difference in the volatile composition of pine-mushrooms (Tricholoma matsutake Sing.) according to their grades. | 2006 Jun 28 |
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| Women's health among the Chumash. | 2006 Mar |
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| Essential oil composition of terminal branches, cones and roots of Tetraclinis articulata from Tunisia. | 2007 Aug 1 |
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| Volatile chemical constituents of Piper aduncum L and Piper gibbilimbum C. DC (Piperaceae) from Papua New Guinea. | 2007 Mar 9 |
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| Anti-inflammation activity of fruit essential oil from Cinnamomum insularimontanum Hayata. | 2008 Dec |
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| [Analysis of volatile oil in pre and post processed pieces of Eriobotrya japonica by GC-MS]. | 2008 Nov |
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| In vitro biological activity of Salvia leriifolia benth essential oil relevant to the treatment of Alzheimer's disease. | 2009 |
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| Chemical composition of hydrodistilled essential oil of Artemisia incana (L.) Druce and antimicrobial activity against foodborne microorganisms. | 2009 Dec |
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| Composition and antibacterial activity of essential oils of Artemisia fragrans Willd. leaves and roots from Iran. | 2009 Feb |
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| Fabrication of HA/TCP scaffolds with a graded and porous structure using a camphene-based freeze-casting method. | 2009 May |
|
| Formaldehyde in the indoor environment. | 2010 Apr 14 |
|
| Cannabinoid receptor 1 binding activity and quantitative analysis of Cannabis sativa L. smoke and vapor. | 2010 Feb |
Patents
Sample Use Guides
In Vitro Use Guide
Curator's Comment:: Camphene induced apoptosis by the intrinsic pathway in melanoma cells mainly by causing endoplasmic reticulum (ER) stress, with release of Ca(2+) together with HmgB1 and calreticulin, loss of mitochondrial membrane potential and up regulation of caspase-3 activity.
Unknown
| Substance Class |
Chemical
Created
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| Record UNII |
G3VG94Z26E
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Validated (UNII)
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21 CFR 172.515
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JECFA EVALUATION |
CAMPHENE
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2395761
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900
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201-234-8
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CAMPHENE
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SUB13212MIG
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6616
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M3002
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79-92-5
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79-92-5
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G3VG94Z26E
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> CONSTITUENT ALWAYS PRESENT |
Monoterpene Class
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PARENT -> CONSTITUENT MAY BE PRESENT |
