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Details

Stereochemistry MIXED
Molecular Formula C10H16
Molecular Weight 136.234
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CAMPHENE

SMILES

CC1(C)C2CCC(C2)C1=C

InChI

InChIKey=CRPUJAZIXJMDBK-UHFFFAOYSA-N
InChI=1S/C10H16/c1-7-8-4-5-9(6-8)10(7,2)3/h8-9H,1,4-6H2,2-3H3

HIDE SMILES / InChI

Molecular Formula C10H16
Molecular Weight 136.234
Charge 0
Count
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 0 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Camphene is a bicyclic monoterpene, a Plant Derived Monoterpene, which possessed antitumor activity. This was found in vivo by inhibiting subcutaneous tumor growth of highly aggressive melanoma cells in a syngeneic model, suggesting a promising role of this compound in cancer therapy. In addition was shown, that camphene lowered cholesterol and triglycerides (TG) in the plasma of hyperlipidemic rats without affecting HMG-CoA reductase activity. And was suggested, that camphene upregulated Sterol regulatory element-binding proteins (SREBP-1) expression and microsomal triglyceride transfer protein (MTP) inhibition was likely to be a probable mechanism whereby camphene exerts its hypolipidemic effect.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P36956|||Q6PJ36
Gene ID: 6720.0
Gene Symbol: SREBF1
Target Organism: Homo sapiens (Human)
Target ID: P55157
Gene ID: 4547.0
Gene Symbol: MTTP
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Foliar and cortex oleoresin variability of silver fir (Abies alba Mill.) in Albania.
2001 Jul-Aug
Organ- and season-dependent variation in the essential oil composition of Salvia officinalis L. cultivated at two different sites.
2001 Jun
The historic camphenyl cation: a detailed structure evaluation including solvation energy calculations.
2001 Nov 2
Identification of odoriferous compounds from adults of a swallowtail butterfly, Papilio machaon (Lepidoptera: Papilionidae).
2001 Nov-Dec
Radiocarbon content of synthetic and natural semi-volatile halogenated organic compounds.
2002
Effects of four mono- and sesquiterpenes on the consumption of alfalfa pellets by sheep.
2002 Dec
Supercritical carbon dioxide extraction of essential oils from Perovskia atriplicifolia Benth.
2003 Aug 27
Antioxidative properties of the essential oil from Pinus mugo.
2003 Dec 17
Ion exchange resins as catalyst for the isomerization of alpha-pinene to camphene.
2004 Jun
Main compounds responsible for off-odour of strawberries infected by Phytophthora cactorum.
2005
Application of artificial neural network on mono- and sesquiterpenes compounds determined by headspace solid-phase microextraction-gas chromatography-mass spectrometry for the Piedmont ricotta cheese traceability.
2005 Apr 15
An experimental study of sexual function improving effect of Myristica fragrans Houtt. (nutmeg).
2005 Jul 20
Biotransformation of terpenoids by mammals, microorganisms, and plant-cultured cells.
2005 May
Measurements of biogenic hydrocarbons and carbonyl compounds emitted by trees from temperate warm Atlantic rainforest, Brazil.
2005 May
Anticonflict effects of lavender oil and identification of its active constituents.
2006 Dec
Biogenic volatile organic compounds (BVOCs) emissions from Abies alba in a French forest.
2006 Feb 1
Maternal food provisioning in relation to condition-dependent offspring odours in burrower bugs (Sehirus cinctus).
2006 Jun 22
[Analysis of volatile constituents in leaves of three cypress species by gas chromatography/mass spectrometry].
2006 Mar
Baseline isotopic data of polyhalogenated compounds.
2006 Sep 8
Chemical composition of the essential oil of Pelargonium quercetorum Agnew. of Iran.
2007 Jan
Volatile organic compounds of Angelica gigas Nakai, Korean medicinal herb.
2007 Mar
Assessment and implications of intraspecific and phenological variability in monoterpenes of Scots pine (Pinus sylvestris) foliage.
2007 Mar
Plant coexistence alters terpene emission and content of Mediterranean species.
2007 Mar
Temperature dependence of the optical rotation in six bicyclic organic molecules calculated by vibrational averaging.
2007 Mar 12
Volatile chemical constituents of Piper aduncum L and Piper gibbilimbum C. DC (Piperaceae) from Papua New Guinea.
2007 Mar 9
Variability of the needle essential oils of Pinus heldreichii from different populations in Montenegro and Serbia.
2007 May
Bimolecular and unimolecular contributions to the disparate self-chemical ionizations of alpha-pinene and camphene isomers.
2007 Nov
Variability of the needle essential oils of Pinus peuce from different populations in Montenegro and Serbia.
2008 Jul
The essential oil qualitative and quantitative composition in the needles of Pinus sylvestris L. growing along industrial transects.
2008 Oct
Rosmarinus officinalis L.: chemical modifications of the essential oil and evaluation of antioxidant and antimicrobial activity.
2009 Dec
Chemical composition of hydrodistilled essential oil of Artemisia incana (L.) Druce and antimicrobial activity against foodborne microorganisms.
2009 Dec
Comparative analysis of essential oils from eight herbal medicines with pungent flavor and cool nature by GC-MS and chemometric resolution methods.
2009 Feb
Formation and stability of secondary ozonides from monoterpenes studied by mass spectrometry.
2009 Jul
Fabrication of HA/TCP scaffolds with a graded and porous structure using a camphene-based freeze-casting method.
2009 May
Effects of a thiosemicarbazide camphene derivative on Trichophyton mentagrophytes.
2009 May 13
Multiple ultrafast, broadband 2D NMR spectra of hyperpolarized natural products.
2009 Oct 7
Formaldehyde in the indoor environment.
2010 Apr 14
Patents

Patents

Sample Use Guides

Unknown
Route of Administration: Other
In Vitro Use Guide
Curator's Comment: Camphene induced apoptosis by the intrinsic pathway in melanoma cells mainly by causing endoplasmic reticulum (ER) stress, with release of Ca(2+) together with HmgB1 and calreticulin, loss of mitochondrial membrane potential and up regulation of caspase-3 activity.
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:42:43 GMT 2025
Edited
by admin
on Mon Mar 31 18:42:43 GMT 2025
Record UNII
G3VG94Z26E
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CAMPHENE
FCC   FHFI   HSDB   INCI   MART.   MI   WHO-DD  
INCI  
Official Name English
FEMA NO. 2229
Preferred Name English
CAMPHENE [FCC]
Common Name English
2,2-DIMETHYL-3-METHYLENENORBORNANE
Systematic Name English
CAMPHENE, D,L-
Common Name English
CAMPHENE [HSDB]
Common Name English
Camphene [WHO-DD]
Common Name English
CAMPHENE, (±)-
Systematic Name English
CAMPHENE, DL-
Common Name English
CAMPHENE [MI]
Common Name English
NSC-4165
Code English
CAMPHENE [MART.]
Common Name English
DL-CAMPHENE
Common Name English
CAMPHENE [FHFI]
Common Name English
(±)-CAMPHENE
Systematic Name English
BICYCLO(2.2.1)HEPTANE, 2,2-DIMETHYL-3-METHYLENE-
Systematic Name English
Classification Tree Code System Code
CFR 21 CFR 172.515
Created by admin on Mon Mar 31 18:42:43 GMT 2025 , Edited by admin on Mon Mar 31 18:42:43 GMT 2025
JECFA EVALUATION CAMPHENE
Created by admin on Mon Mar 31 18:42:43 GMT 2025 , Edited by admin on Mon Mar 31 18:42:43 GMT 2025
Code System Code Type Description
RXCUI
2395761
Created by admin on Mon Mar 31 18:42:43 GMT 2025 , Edited by admin on Mon Mar 31 18:42:43 GMT 2025
PRIMARY
HSDB
900
Created by admin on Mon Mar 31 18:42:43 GMT 2025 , Edited by admin on Mon Mar 31 18:42:43 GMT 2025
PRIMARY
SMS_ID
100000076601
Created by admin on Mon Mar 31 18:42:43 GMT 2025 , Edited by admin on Mon Mar 31 18:42:43 GMT 2025
PRIMARY
ECHA (EC/EINECS)
201-234-8
Created by admin on Mon Mar 31 18:42:43 GMT 2025 , Edited by admin on Mon Mar 31 18:42:43 GMT 2025
PRIMARY
NSC
4165
Created by admin on Mon Mar 31 18:42:43 GMT 2025 , Edited by admin on Mon Mar 31 18:42:43 GMT 2025
PRIMARY
WIKIPEDIA
CAMPHENE
Created by admin on Mon Mar 31 18:42:43 GMT 2025 , Edited by admin on Mon Mar 31 18:42:43 GMT 2025
PRIMARY
DAILYMED
G3VG94Z26E
Created by admin on Mon Mar 31 18:42:43 GMT 2025 , Edited by admin on Mon Mar 31 18:42:43 GMT 2025
PRIMARY
EVMPD
SUB13212MIG
Created by admin on Mon Mar 31 18:42:43 GMT 2025 , Edited by admin on Mon Mar 31 18:42:43 GMT 2025
PRIMARY
PUBCHEM
6616
Created by admin on Mon Mar 31 18:42:43 GMT 2025 , Edited by admin on Mon Mar 31 18:42:43 GMT 2025
PRIMARY
CHEBI
3830
Created by admin on Mon Mar 31 18:42:43 GMT 2025 , Edited by admin on Mon Mar 31 18:42:43 GMT 2025
PRIMARY
JECFA MONOGRAPH
1322
Created by admin on Mon Mar 31 18:42:43 GMT 2025 , Edited by admin on Mon Mar 31 18:42:43 GMT 2025
PRIMARY
MERCK INDEX
m3002
Created by admin on Mon Mar 31 18:42:43 GMT 2025 , Edited by admin on Mon Mar 31 18:42:43 GMT 2025
PRIMARY Merck Index
CAS
79-92-5
Created by admin on Mon Mar 31 18:42:43 GMT 2025 , Edited by admin on Mon Mar 31 18:42:43 GMT 2025
PRIMARY
EPA CompTox
DTXSID8026488
Created by admin on Mon Mar 31 18:42:43 GMT 2025 , Edited by admin on Mon Mar 31 18:42:43 GMT 2025
PRIMARY
FDA UNII
G3VG94Z26E
Created by admin on Mon Mar 31 18:42:43 GMT 2025 , Edited by admin on Mon Mar 31 18:42:43 GMT 2025
PRIMARY
Related Record Type Details
PARENT -> CONSTITUENT ALWAYS PRESENT
Monoterpene Class
PARENT -> CONSTITUENT MAY BE PRESENT