Details
| Stereochemistry | MIXED |
| Molecular Formula | C10H16 |
| Molecular Weight | 136.2344 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 0 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C=C1C2CCC(C2)C1(C)C
InChI
InChIKey=CRPUJAZIXJMDBK-UHFFFAOYSA-N
InChI=1S/C10H16/c1-7-8-4-5-9(6-8)10(7,2)3/h8-9H,1,4-6H2,2-3H3
| Molecular Formula | C10H16 |
| Molecular Weight | 136.2344 |
| Charge | 0 |
| Count |
|
| Stereochemistry | MIXED |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Camphene is a bicyclic monoterpene, a Plant Derived Monoterpene, which possessed antitumor activity. This was found in vivo by inhibiting subcutaneous tumor growth of highly aggressive melanoma cells in a syngeneic model, suggesting a promising role of this compound in cancer therapy. In addition was shown, that camphene lowered cholesterol and triglycerides (TG) in the plasma of hyperlipidemic rats without affecting HMG-CoA reductase activity. And was suggested, that camphene upregulated Sterol regulatory element-binding proteins (SREBP-1) expression and microsomal triglyceride transfer protein (MTP) inhibition was likely to be a probable mechanism whereby camphene exerts its hypolipidemic effect.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: P36956|||Q6PJ36 Gene ID: 6720.0 Gene Symbol: SREBF1 Target Organism: Homo sapiens (Human) |
|||
Target ID: P55157 Gene ID: 4547.0 Gene Symbol: MTTP Target Organism: Homo sapiens (Human) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| (M)VOC and composting facilities. Part 2: (M)VOC dispersal in the environment. | 2004 |
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| The effect of selected monoterpenoids on the cellular slime mold, Dictyostelium discoideum NC4. | 2004 Jun |
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| Main compounds responsible for off-odour of strawberries infected by Phytophthora cactorum. | 2005 |
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| Improving pulse sequences for 3D DOSY: convection compensation. | 2005 Dec |
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| Gas chromatography-mass spectrometry study of the essential oils of Schinus longifolia (Lindl.) speg., Schinus fasciculata (Griseb.) I. M. Johnst., and Schinus areira L. | 2005 Jan-Feb |
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| How rainfall, relative humidity and temperature influence volatile emissions from apple trees in situ. | 2005 Jul |
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| Characteristic odor components of kumquat (Fortunella japonica Swingle) peel oil. | 2005 Mar 9 |
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| Biotransformation of terpenoids by mammals, microorganisms, and plant-cultured cells. | 2005 May |
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| Anticonflict effects of lavender oil and identification of its active constituents. | 2006 Dec |
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| Gitksan medicinal plants--cultural choice and efficacy. | 2006 Jun 21 |
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| Maternal food provisioning in relation to condition-dependent offspring odours in burrower bugs (Sehirus cinctus). | 2006 Jun 22 |
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| Difference in the volatile composition of pine-mushrooms (Tricholoma matsutake Sing.) according to their grades. | 2006 Jun 28 |
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| [Analysis of volatile constituents in leaves of three cypress species by gas chromatography/mass spectrometry]. | 2006 Mar |
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| Synthesis of low and high chlorinated toxaphene and comparison of their toxicity by zebrafish (Danio rerio) embryo test. | 2006 Nov |
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| Baseline isotopic data of polyhalogenated compounds. | 2006 Sep 8 |
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| Essential oil composition of terminal branches, cones and roots of Tetraclinis articulata from Tunisia. | 2007 Aug 1 |
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| Chemical compositions of the essential oils of stems, leaves and flowers of Prangos acaulis (Dc) Bornm. | 2007 Aug 15 |
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| Chemical composition of the essential oil of Pelargonium quercetorum Agnew. of Iran. | 2007 Jan |
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| Volatile organic compounds of Angelica gigas Nakai, Korean medicinal herb. | 2007 Mar |
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| Assessment and implications of intraspecific and phenological variability in monoterpenes of Scots pine (Pinus sylvestris) foliage. | 2007 Mar |
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| Plant coexistence alters terpene emission and content of Mediterranean species. | 2007 Mar |
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| Analysis by gas chromatography-mass spectrometry of essential oil from seeds and aerial parts of Ferulago angulata (Schlecht.) Boiss gathered in Nevakoh and Shahoo, Zagross mountain, West of Iran. | 2007 Mar 1 |
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| Temperature dependence of the optical rotation in six bicyclic organic molecules calculated by vibrational averaging. | 2007 Mar 12 |
|
| The formation of ultra-fine particles during ozone-initiated oxidations with terpenes emitted from natural paint. | 2007 Mar 6 |
|
| Variability of the needle essential oils of Pinus heldreichii from different populations in Montenegro and Serbia. | 2007 May |
|
| Anti-inflammation activity of fruit essential oil from Cinnamomum insularimontanum Hayata. | 2008 Dec |
|
| The oil-dispersion bath in anthroposophic medicine--an integrative review. | 2008 Dec 4 |
|
| Variability of the needle essential oils of Pinus peuce from different populations in Montenegro and Serbia. | 2008 Jul |
|
| Activity of essential oils and individual components against acetyl- and butyrylcholinesterase. | 2008 Jul-Aug |
|
| [Analysis of volatile oil in pre and post processed pieces of Eriobotrya japonica by GC-MS]. | 2008 Nov |
|
| [Characterization of chemical components of essential oil from flowers of Chrysanthemum morifolium produced in Anhui province]. | 2008 Oct |
|
| In vitro biological activity of Salvia leriifolia benth essential oil relevant to the treatment of Alzheimer's disease. | 2009 |
|
| Antinociceptive effect and GC/MS analysis of Rosmarinus officinalis L. essential oil from its aerial parts. | 2009 Apr |
|
| Fingerprint of selected Salvia species by HS-GC-MS analysis of their volatile fraction. | 2009 Aug |
|
| Temperature-dependent release of volatile organic compounds of eucalypts by direct analysis in real time (DART) mass spectrometry. | 2009 Aug |
|
| Rosmarinus officinalis L.: chemical modifications of the essential oil and evaluation of antioxidant and antimicrobial activity. | 2009 Dec |
|
| Chemical composition of hydrodistilled essential oil of Artemisia incana (L.) Druce and antimicrobial activity against foodborne microorganisms. | 2009 Dec |
|
| Essential oil variability in natural populations of Picea omorika, a rare European conifer. | 2009 Feb |
|
| Comparative analysis of essential oils from eight herbal medicines with pungent flavor and cool nature by GC-MS and chemometric resolution methods. | 2009 Feb |
|
| Tissue engineering polymeric microcarriers with macroporous morphology and bone-bioactive surface. | 2009 Jul 7 |
|
| Composition and seasonal variation of the essential oil from Abies sachalinensis from Hokkaido, Japan. | 2009 Jun |
|
| Terpenoid emissions from Quercus robur. A case study of Galicia (NW Spain). | 2009 Jun |
|
| Preparation of porous bioactive ceramic microspheres and in vitro osteoblastic culturing for tissue engineering application. | 2009 Jun |
|
| Plant derived antioxidants - Geraniol and camphene protect rat alveolar macrophages against t-BHP induced oxidative stress. | 2009 Mar |
|
| Fabrication of HA/TCP scaffolds with a graded and porous structure using a camphene-based freeze-casting method. | 2009 May |
|
| Influence of growth phase and geographic origin on the essential oil composition of Pituranthos chloranthus from Tunisia. | 2009 Nov |
|
| Multiple ultrafast, broadband 2D NMR spectra of hyperpolarized natural products. | 2009 Oct 7 |
|
| Formaldehyde in the indoor environment. | 2010 Apr 14 |
|
| Comparative chemical composition and antiproliferative activity of aerial parts of Salvia leriifolia Benth. and Salvia acetabulosa L. essential oils against human tumor cell in vitro models. | 2010 Feb |
|
| Cannabinoid receptor 1 binding activity and quantitative analysis of Cannabis sativa L. smoke and vapor. | 2010 Feb |
Patents
Sample Use Guides
In Vitro Use Guide
Curator's Comment:: Camphene induced apoptosis by the intrinsic pathway in melanoma cells mainly by causing endoplasmic reticulum (ER) stress, with release of Ca(2+) together with HmgB1 and calreticulin, loss of mitochondrial membrane potential and up regulation of caspase-3 activity.
Unknown
| Substance Class |
Chemical
Created
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admin
on
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Sat Jun 26 14:47:59 UTC 2021
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| Record UNII |
G3VG94Z26E
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| Record Status |
Validated (UNII)
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21 CFR 172.515
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JECFA EVALUATION |
CAMPHENE
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2395761
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900
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201-234-8
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CAMPHENE
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SUB13212MIG
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6616
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M3002
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79-92-5
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79-92-5
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G3VG94Z26E
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| Related Record | Type | Details | ||
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PARENT -> CONSTITUENT ALWAYS PRESENT |
Monoterpene Class
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PARENT -> CONSTITUENT MAY BE PRESENT |
