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Details

Stereochemistry MIXED
Molecular Formula C10H16
Molecular Weight 136.2344
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CAMPHENE

SMILES

C=C1C2CCC(C2)C1(C)C

InChI

InChIKey=CRPUJAZIXJMDBK-UHFFFAOYSA-N
InChI=1S/C10H16/c1-7-8-4-5-9(6-8)10(7,2)3/h8-9H,1,4-6H2,2-3H3

HIDE SMILES / InChI

Molecular Formula C10H16
Molecular Weight 136.2344
Charge 0
Count
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 0 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Camphene is a bicyclic monoterpene, a Plant Derived Monoterpene, which possessed antitumor activity. This was found in vivo by inhibiting subcutaneous tumor growth of highly aggressive melanoma cells in a syngeneic model, suggesting a promising role of this compound in cancer therapy. In addition was shown, that camphene lowered cholesterol and triglycerides (TG) in the plasma of hyperlipidemic rats without affecting HMG-CoA reductase activity. And was suggested, that camphene upregulated Sterol regulatory element-binding proteins (SREBP-1) expression and microsomal triglyceride transfer protein (MTP) inhibition was likely to be a probable mechanism whereby camphene exerts its hypolipidemic effect.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P36956|||Q6PJ36
Gene ID: 6720.0
Gene Symbol: SREBF1
Target Organism: Homo sapiens (Human)
Target ID: P55157
Gene ID: 4547.0
Gene Symbol: MTTP
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Age and space distributions of monoterpenes in fresh needles of Picea abies (L) Karst. Determined by gas chromatography-mass spectrometry.
2001 Jul-Aug
Seasonal changes in the composition of the essential oil extract of East Mediterranean sage (Salvia libanotica) and its toxicity in mice.
2001 Oct
Wet effluent diffusion denuder technique and the determination of volatile organic compounds in air. II. Monoterpenes.
2002 Oct 11
Attempt to unravel the composition of toxaphene by comprehensive two-dimensional gas chromatography with selective detection.
2003 Apr 25
Antioxidative properties of the essential oil from Pinus mugo.
2003 Dec 17
Evaluation of different formulation studies on air-filled polymeric microcapsules by multivariate analysis.
2003 May 12
(M)VOC and composting facilities. Part 2: (M)VOC dispersal in the environment.
2004
Essential oil of Valeriana officinalis L. cultivars and their antimicrobial activity as influenced by harvesting time under commercial organic cultivation.
2004 Jun 16
chemical composition, plant genetic differences, antimicrobial and antifungal activity investigation of the essential oil of Rosmarinus officinalis L.
2004 Jun 2
Main compounds responsible for off-odour of strawberries infected by Phytophthora cactorum.
2005
Application of artificial neural network on mono- and sesquiterpenes compounds determined by headspace solid-phase microextraction-gas chromatography-mass spectrometry for the Piedmont ricotta cheese traceability.
2005 Apr 15
Improving pulse sequences for 3D DOSY: convection compensation.
2005 Dec
How rainfall, relative humidity and temperature influence volatile emissions from apple trees in situ.
2005 Jul
An experimental study of sexual function improving effect of Myristica fragrans Houtt. (nutmeg).
2005 Jul 20
Analysis of aroma and phenolic components of selected Achillea species.
2005 Jun
Identification of an EcoRI restriction site for a rapid and precise determination of beta-asarone-free Acorus calamus cytotypes.
2005 Mar
Allelopathic effects of volatile monoterpenoids produced by Salvia leucophylla: Inhibition of cell proliferation and DNA synthesis in the root apical meristem of Brassica campestris seedlings.
2005 May
Biogenic volatile organic compounds (BVOCs) emissions from Abies alba in a French forest.
2006 Feb 1
Gitksan medicinal plants--cultural choice and efficacy.
2006 Jun 21
Difference in the volatile composition of pine-mushrooms (Tricholoma matsutake Sing.) according to their grades.
2006 Jun 28
Women's health among the Chumash.
2006 Mar
Essential oil composition of terminal branches, cones and roots of Tetraclinis articulata from Tunisia.
2007 Aug 1
Volatile chemical constituents of Piper aduncum L and Piper gibbilimbum C. DC (Piperaceae) from Papua New Guinea.
2007 Mar 9
Anti-inflammation activity of fruit essential oil from Cinnamomum insularimontanum Hayata.
2008 Dec
[Analysis of volatile oil in pre and post processed pieces of Eriobotrya japonica by GC-MS].
2008 Nov
In vitro biological activity of Salvia leriifolia benth essential oil relevant to the treatment of Alzheimer's disease.
2009
Chemical composition of hydrodistilled essential oil of Artemisia incana (L.) Druce and antimicrobial activity against foodborne microorganisms.
2009 Dec
Composition and antibacterial activity of essential oils of Artemisia fragrans Willd. leaves and roots from Iran.
2009 Feb
Fabrication of HA/TCP scaffolds with a graded and porous structure using a camphene-based freeze-casting method.
2009 May
Formaldehyde in the indoor environment.
2010 Apr 14
Cannabinoid receptor 1 binding activity and quantitative analysis of Cannabis sativa L. smoke and vapor.
2010 Feb
Patents

Patents

Sample Use Guides

Unknown
Route of Administration: Other
In Vitro Use Guide
Curator's Comment:: Camphene induced apoptosis by the intrinsic pathway in melanoma cells mainly by causing endoplasmic reticulum (ER) stress, with release of Ca(2+) together with HmgB1 and calreticulin, loss of mitochondrial membrane potential and up regulation of caspase-3 activity.
Unknown
Substance Class Chemical
Created
by admin
on Sat Jun 26 14:47:59 UTC 2021
Edited
by admin
on Sat Jun 26 14:47:59 UTC 2021
Record UNII
G3VG94Z26E
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CAMPHENE
FCC   FHFI   HSDB   INCI   MART.   MI   WHO-DD  
INCI  
Official Name English
CAMPHENE [FCC]
Common Name English
2,2-DIMETHYL-3-METHYLENENORBORNANE
Systematic Name English
CAMPHENE, D,L-
Common Name English
CAMPHENE [HSDB]
Common Name English
CAMPHENE, (+/-)-
Systematic Name English
CAMPHENE, DL-
Common Name English
CAMPHENE [MI]
Common Name English
NSC-4165
Code English
CAMPHENE [INCI]
Common Name English
CAMPHENE [MART.]
Common Name English
DL-CAMPHENE
Common Name English
FEMA NO. 2229
Code English
CAMPHENE [WHO-DD]
Common Name English
CAMPHENE [FHFI]
Common Name English
(+/-)-CAMPHENE
Systematic Name English
BICYCLO(2.2.1)HEPTANE, 2,2-DIMETHYL-3-METHYLENE-
Systematic Name English
Classification Tree Code System Code
CFR 21 CFR 172.515
Created by admin on Sat Jun 26 14:47:59 UTC 2021 , Edited by admin on Sat Jun 26 14:47:59 UTC 2021
JECFA EVALUATION CAMPHENE
Created by admin on Sat Jun 26 14:47:59 UTC 2021 , Edited by admin on Sat Jun 26 14:47:59 UTC 2021
Code System Code Type Description
RXCUI
2395761
Created by admin on Sat Jun 26 14:47:59 UTC 2021 , Edited by admin on Sat Jun 26 14:47:59 UTC 2021
PRIMARY
HSDB
900
Created by admin on Sat Jun 26 14:47:59 UTC 2021 , Edited by admin on Sat Jun 26 14:47:59 UTC 2021
PRIMARY
ECHA (EC/EINECS)
201-234-8
Created by admin on Sat Jun 26 14:47:59 UTC 2021 , Edited by admin on Sat Jun 26 14:47:59 UTC 2021
PRIMARY
WIKIPEDIA
CAMPHENE
Created by admin on Sat Jun 26 14:47:59 UTC 2021 , Edited by admin on Sat Jun 26 14:47:59 UTC 2021
PRIMARY
EVMPD
SUB13212MIG
Created by admin on Sat Jun 26 14:47:59 UTC 2021 , Edited by admin on Sat Jun 26 14:47:59 UTC 2021
PRIMARY
PUBCHEM
6616
Created by admin on Sat Jun 26 14:47:59 UTC 2021 , Edited by admin on Sat Jun 26 14:47:59 UTC 2021
PRIMARY
MERCK INDEX
M3002
Created by admin on Sat Jun 26 14:47:59 UTC 2021 , Edited by admin on Sat Jun 26 14:47:59 UTC 2021
PRIMARY Merck Index
CAS
79-92-5
Created by admin on Sat Jun 26 14:47:59 UTC 2021 , Edited by admin on Sat Jun 26 14:47:59 UTC 2021
PRIMARY
EPA CompTox
79-92-5
Created by admin on Sat Jun 26 14:47:59 UTC 2021 , Edited by admin on Sat Jun 26 14:47:59 UTC 2021
PRIMARY
FDA UNII
G3VG94Z26E
Created by admin on Sat Jun 26 14:47:59 UTC 2021 , Edited by admin on Sat Jun 26 14:47:59 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> CONSTITUENT ALWAYS PRESENT
Monoterpene Class
PARENT -> CONSTITUENT MAY BE PRESENT