Details
| Stereochemistry | MIXED |
| Molecular Formula | C10H16 |
| Molecular Weight | 136.234 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 0 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1(C)C2CCC(C2)C1=C
InChI
InChIKey=CRPUJAZIXJMDBK-UHFFFAOYSA-N
InChI=1S/C10H16/c1-7-8-4-5-9(6-8)10(7,2)3/h8-9H,1,4-6H2,2-3H3
| Molecular Formula | C10H16 |
| Molecular Weight | 136.234 |
| Charge | 0 |
| Count |
|
| Stereochemistry | MIXED |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Camphene is a bicyclic monoterpene, a Plant Derived Monoterpene, which possessed antitumor activity. This was found in vivo by inhibiting subcutaneous tumor growth of highly aggressive melanoma cells in a syngeneic model, suggesting a promising role of this compound in cancer therapy. In addition was shown, that camphene lowered cholesterol and triglycerides (TG) in the plasma of hyperlipidemic rats without affecting HMG-CoA reductase activity. And was suggested, that camphene upregulated Sterol regulatory element-binding proteins (SREBP-1) expression and microsomal triglyceride transfer protein (MTP) inhibition was likely to be a probable mechanism whereby camphene exerts its hypolipidemic effect.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: P36956|||Q6PJ36 Gene ID: 6720.0 Gene Symbol: SREBF1 Target Organism: Homo sapiens (Human) |
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Target ID: P55157 Gene ID: 4547.0 Gene Symbol: MTTP Target Organism: Homo sapiens (Human) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Foliar and cortex oleoresin variability of silver fir (Abies alba Mill.) in Albania. | 2001 Jul-Aug |
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| Organ- and season-dependent variation in the essential oil composition of Salvia officinalis L. cultivated at two different sites. | 2001 Jun |
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| The historic camphenyl cation: a detailed structure evaluation including solvation energy calculations. | 2001 Nov 2 |
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| Identification of odoriferous compounds from adults of a swallowtail butterfly, Papilio machaon (Lepidoptera: Papilionidae). | 2001 Nov-Dec |
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| Radiocarbon content of synthetic and natural semi-volatile halogenated organic compounds. | 2002 |
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| Effects of four mono- and sesquiterpenes on the consumption of alfalfa pellets by sheep. | 2002 Dec |
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| Supercritical carbon dioxide extraction of essential oils from Perovskia atriplicifolia Benth. | 2003 Aug 27 |
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| Antioxidative properties of the essential oil from Pinus mugo. | 2003 Dec 17 |
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| Ion exchange resins as catalyst for the isomerization of alpha-pinene to camphene. | 2004 Jun |
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| Main compounds responsible for off-odour of strawberries infected by Phytophthora cactorum. | 2005 |
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| Application of artificial neural network on mono- and sesquiterpenes compounds determined by headspace solid-phase microextraction-gas chromatography-mass spectrometry for the Piedmont ricotta cheese traceability. | 2005 Apr 15 |
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| An experimental study of sexual function improving effect of Myristica fragrans Houtt. (nutmeg). | 2005 Jul 20 |
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| Biotransformation of terpenoids by mammals, microorganisms, and plant-cultured cells. | 2005 May |
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| Measurements of biogenic hydrocarbons and carbonyl compounds emitted by trees from temperate warm Atlantic rainforest, Brazil. | 2005 May |
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| Anticonflict effects of lavender oil and identification of its active constituents. | 2006 Dec |
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| Biogenic volatile organic compounds (BVOCs) emissions from Abies alba in a French forest. | 2006 Feb 1 |
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| Maternal food provisioning in relation to condition-dependent offspring odours in burrower bugs (Sehirus cinctus). | 2006 Jun 22 |
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| [Analysis of volatile constituents in leaves of three cypress species by gas chromatography/mass spectrometry]. | 2006 Mar |
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| Baseline isotopic data of polyhalogenated compounds. | 2006 Sep 8 |
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| Chemical composition of the essential oil of Pelargonium quercetorum Agnew. of Iran. | 2007 Jan |
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| Volatile organic compounds of Angelica gigas Nakai, Korean medicinal herb. | 2007 Mar |
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| Assessment and implications of intraspecific and phenological variability in monoterpenes of Scots pine (Pinus sylvestris) foliage. | 2007 Mar |
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| Plant coexistence alters terpene emission and content of Mediterranean species. | 2007 Mar |
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| Temperature dependence of the optical rotation in six bicyclic organic molecules calculated by vibrational averaging. | 2007 Mar 12 |
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| Volatile chemical constituents of Piper aduncum L and Piper gibbilimbum C. DC (Piperaceae) from Papua New Guinea. | 2007 Mar 9 |
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| Variability of the needle essential oils of Pinus heldreichii from different populations in Montenegro and Serbia. | 2007 May |
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| Bimolecular and unimolecular contributions to the disparate self-chemical ionizations of alpha-pinene and camphene isomers. | 2007 Nov |
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| Variability of the needle essential oils of Pinus peuce from different populations in Montenegro and Serbia. | 2008 Jul |
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| The essential oil qualitative and quantitative composition in the needles of Pinus sylvestris L. growing along industrial transects. | 2008 Oct |
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| Rosmarinus officinalis L.: chemical modifications of the essential oil and evaluation of antioxidant and antimicrobial activity. | 2009 Dec |
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| Chemical composition of hydrodistilled essential oil of Artemisia incana (L.) Druce and antimicrobial activity against foodborne microorganisms. | 2009 Dec |
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| Comparative analysis of essential oils from eight herbal medicines with pungent flavor and cool nature by GC-MS and chemometric resolution methods. | 2009 Feb |
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| Formation and stability of secondary ozonides from monoterpenes studied by mass spectrometry. | 2009 Jul |
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| Fabrication of HA/TCP scaffolds with a graded and porous structure using a camphene-based freeze-casting method. | 2009 May |
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| Effects of a thiosemicarbazide camphene derivative on Trichophyton mentagrophytes. | 2009 May 13 |
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| Multiple ultrafast, broadband 2D NMR spectra of hyperpolarized natural products. | 2009 Oct 7 |
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| Formaldehyde in the indoor environment. | 2010 Apr 14 |
Patents
Sample Use Guides
In Vitro Use Guide
Curator's Comment: Camphene induced apoptosis by the intrinsic pathway in melanoma cells mainly by causing endoplasmic reticulum (ER) stress, with release of Ca(2+) together with HmgB1 and calreticulin, loss of mitochondrial membrane potential and up regulation of caspase-3 activity.
Unknown
| Substance Class |
Chemical
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G3VG94Z26E
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21 CFR 172.515
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JECFA EVALUATION |
CAMPHENE
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2395761
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900
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CAMPHENE
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| Related Record | Type | Details | ||
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PARENT -> CONSTITUENT ALWAYS PRESENT |
Monoterpene Class
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PARENT -> CONSTITUENT MAY BE PRESENT |
