Details
| Stereochemistry | MIXED |
| Molecular Formula | C10H16 |
| Molecular Weight | 136.234 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 0 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1(C)C2CCC(C2)C1=C
InChI
InChIKey=CRPUJAZIXJMDBK-UHFFFAOYSA-N
InChI=1S/C10H16/c1-7-8-4-5-9(6-8)10(7,2)3/h8-9H,1,4-6H2,2-3H3
| Molecular Formula | C10H16 |
| Molecular Weight | 136.234 |
| Charge | 0 |
| Count |
|
| Stereochemistry | MIXED |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Camphene is a bicyclic monoterpene, a Plant Derived Monoterpene, which possessed antitumor activity. This was found in vivo by inhibiting subcutaneous tumor growth of highly aggressive melanoma cells in a syngeneic model, suggesting a promising role of this compound in cancer therapy. In addition was shown, that camphene lowered cholesterol and triglycerides (TG) in the plasma of hyperlipidemic rats without affecting HMG-CoA reductase activity. And was suggested, that camphene upregulated Sterol regulatory element-binding proteins (SREBP-1) expression and microsomal triglyceride transfer protein (MTP) inhibition was likely to be a probable mechanism whereby camphene exerts its hypolipidemic effect.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: P36956|||Q6PJ36 Gene ID: 6720.0 Gene Symbol: SREBF1 Target Organism: Homo sapiens (Human) |
|||
Target ID: P55157 Gene ID: 4547.0 Gene Symbol: MTTP Target Organism: Homo sapiens (Human) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Identification of odoriferous compounds from adults of a swallowtail butterfly, Papilio machaon (Lepidoptera: Papilionidae). | 2001 Nov-Dec |
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| Radiocarbon content of synthetic and natural semi-volatile halogenated organic compounds. | 2002 |
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| Sensitive indoor air monitoring of monoterpenes using different adsorbents and thermal desorption gas chromatography with mass-selective detection. | 2002 Jul 12 |
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| Wet effluent diffusion denuder technique and the determination of volatile organic compounds in air. II. Monoterpenes. | 2002 Oct 11 |
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| Attempt to unravel the composition of toxaphene by comprehensive two-dimensional gas chromatography with selective detection. | 2003 Apr 25 |
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| Essential oils produced by in vitro shoots of sage (Salvia officinalis L.). | 2003 Apr 9 |
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| Effect of the volatile constituents isolated from Thymus albicans, Th. mastichina, Th. carnosus and Thymbra capitata in sunflower oil. | 2003 Dec |
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| Volatile emissions of eastern hemlock, Tsuga canadensis, and the influence of hemlock woolly adelgid. | 2003 Jan |
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| (M)VOC and composting facilities. Part 2: (M)VOC dispersal in the environment. | 2004 |
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| Ion exchange resins as catalyst for the isomerization of alpha-pinene to camphene. | 2004 Jun |
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| Essential oil of Valeriana officinalis L. cultivars and their antimicrobial activity as influenced by harvesting time under commercial organic cultivation. | 2004 Jun 16 |
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| Chemical composition and antimicrobial activity of the essential oils from the gum of Turkish pistachio (Pistacia vera L.). | 2004 Jun 16 |
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| Full-scale chamber investigation and simulation of air freshener emissions in the presence of ozone. | 2004 May 15 |
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| Application of artificial neural network on mono- and sesquiterpenes compounds determined by headspace solid-phase microextraction-gas chromatography-mass spectrometry for the Piedmont ricotta cheese traceability. | 2005 Apr 15 |
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| Changes in anatomy and terpene chemistry in roots of Douglas-fir seedlings following treatment with methyl jasmonate. | 2005 Aug |
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| How rainfall, relative humidity and temperature influence volatile emissions from apple trees in situ. | 2005 Jul |
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| An experimental study of sexual function improving effect of Myristica fragrans Houtt. (nutmeg). | 2005 Jul 20 |
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| Characteristic odor components of kumquat (Fortunella japonica Swingle) peel oil. | 2005 Mar 9 |
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| Allelopathic effects of volatile monoterpenoids produced by Salvia leucophylla: Inhibition of cell proliferation and DNA synthesis in the root apical meristem of Brassica campestris seedlings. | 2005 May |
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| Anticonflict effects of lavender oil and identification of its active constituents. | 2006 Dec |
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| Biogenic volatile organic compounds (BVOCs) emissions from Abies alba in a French forest. | 2006 Feb 1 |
|
| Establishing a chromium-reactor design for measuring delta2H values of solid polyhalogenated compounds using direct elemental analysis and stable isotope ratio mass spectrometry. | 2006 Jan |
|
| Chemical composition and biological activities of essential oil from the leaves of Sesuvium portulacastrum. | 2006 Jan 3 |
|
| [Analysis of volatile constituents in leaves of three cypress species by gas chromatography/mass spectrometry]. | 2006 Mar |
|
| Women's health among the Chumash. | 2006 Mar |
|
| Baseline isotopic data of polyhalogenated compounds. | 2006 Sep 8 |
|
| Essential oil composition of terminal branches, cones and roots of Tetraclinis articulata from Tunisia. | 2007 Aug 1 |
|
| Chemical compositions of the essential oils of stems, leaves and flowers of Prangos acaulis (Dc) Bornm. | 2007 Aug 15 |
|
| Plant coexistence alters terpene emission and content of Mediterranean species. | 2007 Mar |
|
| The formation of ultra-fine particles during ozone-initiated oxidations with terpenes emitted from natural paint. | 2007 Mar 6 |
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| Variability of the needle essential oils of Pinus heldreichii from different populations in Montenegro and Serbia. | 2007 May |
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| The oil-dispersion bath in anthroposophic medicine--an integrative review. | 2008 Dec 4 |
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| Activity of essential oils and individual components against acetyl- and butyrylcholinesterase. | 2008 Jul-Aug |
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| Effects of cis-beta-ocimene, cis-sabinene hydrate, and monoterpene and sesquiterpene mixtures on alfalfa pellet intake by lambs. | 2008 Jun |
|
| Mass propagation and essential oil analysis of Artemisia vulgaris. | 2008 Mar |
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| Speedy component resolution: an improved tool for processing diffusion-ordered spectroscopy data. | 2008 May 15 |
|
| [Characterization of chemical components of essential oil from flowers of Chrysanthemum morifolium produced in Anhui province]. | 2008 Oct |
|
| In vitro biological activity of Salvia leriifolia benth essential oil relevant to the treatment of Alzheimer's disease. | 2009 |
|
| Antinociceptive effect and GC/MS analysis of Rosmarinus officinalis L. essential oil from its aerial parts. | 2009 Apr |
|
| Rosmarinus officinalis L.: chemical modifications of the essential oil and evaluation of antioxidant and antimicrobial activity. | 2009 Dec |
|
| Essential oil variability in natural populations of Picea omorika, a rare European conifer. | 2009 Feb |
|
| Comparative analysis of essential oils from eight herbal medicines with pungent flavor and cool nature by GC-MS and chemometric resolution methods. | 2009 Feb |
|
| Formation and stability of secondary ozonides from monoterpenes studied by mass spectrometry. | 2009 Jul |
|
| Preparation of porous bioactive ceramic microspheres and in vitro osteoblastic culturing for tissue engineering application. | 2009 Jun |
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| Plant derived antioxidants - Geraniol and camphene protect rat alveolar macrophages against t-BHP induced oxidative stress. | 2009 Mar |
|
| Fumigant and contact toxicities of monoterpenes to Sitophilus oryzae (L.) and Tribolium castaneum (Herbst) and their inhibitory effects on acetylcholinesterase activity. | 2009 May |
|
| Fabrication of HA/TCP scaffolds with a graded and porous structure using a camphene-based freeze-casting method. | 2009 May |
|
| Multiple ultrafast, broadband 2D NMR spectra of hyperpolarized natural products. | 2009 Oct 7 |
|
| Formaldehyde in the indoor environment. | 2010 Apr 14 |
|
| Comparative chemical composition and antiproliferative activity of aerial parts of Salvia leriifolia Benth. and Salvia acetabulosa L. essential oils against human tumor cell in vitro models. | 2010 Feb |
Patents
Sample Use Guides
In Vitro Use Guide
Curator's Comment: Camphene induced apoptosis by the intrinsic pathway in melanoma cells mainly by causing endoplasmic reticulum (ER) stress, with release of Ca(2+) together with HmgB1 and calreticulin, loss of mitochondrial membrane potential and up regulation of caspase-3 activity.
Unknown
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 16 21:53:30 UTC 2022
by
admin
on
Fri Dec 16 21:53:30 UTC 2022
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| Record UNII |
G3VG94Z26E
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| Record Status |
Validated (UNII)
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| Record Version |
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21 CFR 172.515
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JECFA EVALUATION |
CAMPHENE
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2395761
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900
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201-234-8
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4165
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CAMPHENE
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G3VG94Z26E
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3830
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M3002
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79-92-5
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| Related Record | Type | Details | ||
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PARENT -> CONSTITUENT ALWAYS PRESENT |
Monoterpene Class
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PARENT -> CONSTITUENT MAY BE PRESENT |
