Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C17H25N5O2 |
| Molecular Weight | 331.4127 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)(C)NCC(O)COC1=CC=CC=C1C2=NN=C(NN)C=C2
InChI
InChIKey=QGONODUKOFNSOY-UHFFFAOYSA-N
InChI=1S/C17H25N5O2/c1-17(2,3)19-10-12(23)11-24-15-7-5-4-6-13(15)14-8-9-16(20-18)22-21-14/h4-9,12,19,23H,10-11,18H2,1-3H3,(H,20,22)
Prizidilol (also known as SKF 92657) is arylpyridazinylhydrazine derivative patented by Smith Kline and French Laboratories Ltd. as an antihypertensive agent. In clinical trials, Supine and standing blood pressure measured 24--27 h after drug intake was reduced Slight but significant decreases in heart rate were seen after moderate doses of prizidilol. A more pronounced blood pressure reduction was noticed 2--7 h after drug administration. Prizidilol was well tolerated, although dizziness and tiredness were reported by four patients and edema by two.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| SK&F 92657, a novel antihypertensive acting by precapillary vasodilatation and beta-adrenoreceptor blockade. | 1979 Dec |
|
| Studies on the autonomic nervous system with SK&F 92657, a new antihypertensive agent causing direct arterial vasodilatation and beta-adrenoceptor blockade. | 1981 Mar-Apr |
|
| Hemodynamic profile of a new antihypertensive agent D,L-3-[2-(3-t-butylamino-2-hydroxypropoxy)phenyl]-6-hydrazinopyridazine (SK&F 92657). | 1981 Mar-Apr |
|
| Clinical pharmacology and pharmacokinetics of prizidilol in hypertensive patients. | 1983 Nov-Dec |
Patents
| Name | Type | Language | ||
|---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
NCI_THESAURUS |
C29576
Created by
admin on Sat Dec 16 17:59:00 GMT 2023 , Edited by admin on Sat Dec 16 17:59:00 GMT 2023
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
DTXSID80866727
Created by
admin on Sat Dec 16 17:59:00 GMT 2023 , Edited by admin on Sat Dec 16 17:59:00 GMT 2023
|
PRIMARY | |||
|
59010-44-5
Created by
admin on Sat Dec 16 17:59:00 GMT 2023 , Edited by admin on Sat Dec 16 17:59:00 GMT 2023
|
PRIMARY | |||
|
G29795CN0B
Created by
admin on Sat Dec 16 17:59:00 GMT 2023 , Edited by admin on Sat Dec 16 17:59:00 GMT 2023
|
PRIMARY | |||
|
CHEMBL119865
Created by
admin on Sat Dec 16 17:59:00 GMT 2023 , Edited by admin on Sat Dec 16 17:59:00 GMT 2023
|
PRIMARY | |||
|
C84106
Created by
admin on Sat Dec 16 17:59:00 GMT 2023 , Edited by admin on Sat Dec 16 17:59:00 GMT 2023
|
PRIMARY | |||
|
72848-98-7
Created by
admin on Sat Dec 16 17:59:00 GMT 2023 , Edited by admin on Sat Dec 16 17:59:00 GMT 2023
|
SUPERSEDED | |||
|
4557
Created by
admin on Sat Dec 16 17:59:00 GMT 2023 , Edited by admin on Sat Dec 16 17:59:00 GMT 2023
|
PRIMARY | |||
|
SUB10050MIG
Created by
admin on Sat Dec 16 17:59:00 GMT 2023 , Edited by admin on Sat Dec 16 17:59:00 GMT 2023
|
PRIMARY | |||
|
C024293
Created by
admin on Sat Dec 16 17:59:00 GMT 2023 , Edited by admin on Sat Dec 16 17:59:00 GMT 2023
|
PRIMARY | |||
|
100000081109
Created by
admin on Sat Dec 16 17:59:00 GMT 2023 , Edited by admin on Sat Dec 16 17:59:00 GMT 2023
|
PRIMARY | |||
|
71952
Created by
admin on Sat Dec 16 17:59:00 GMT 2023 , Edited by admin on Sat Dec 16 17:59:00 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)
SALT/SOLVATE (PARENT)
