HYDROCOTARNINE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H15NO3
Molecular Weight	221.2524
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

COC1=C2OCOC2=CC3=C1CN(C)CC3

InChI

InChIKey=XXANNZJIZQTCBP-UHFFFAOYSA-N

InChI=1S/C12H15NO3/c1-13-4-3-8-5-10-12(16-7-15-10)11(14-2)9(8)6-13/h5H,3-4,6-7H2,1-2H3

HIDE SMILES / InChI

Description

Hydrocotarnine is a crystalline alkaloid, obtained from opium and also formed by the reduction of cotarnine. It is a non-narcotic opium alkaloid. Hydrocotarnine is supposed to potentiate the analgesic effect of oxycodone with unknown mechanism.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cytochrome P450 3A4	Inhibitor		18.4 µM [IC50]
Cytochrome P450 2D6	Inhibitor		6.63 µM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Cancer pain	Primary		Approved	Unknown

PubMed

Show entries

Title	Date	PubMed
[Efficacy and safety of compound oxycodone injection for cancer pain relief-a multicenter survey of prescriptions].	2010 May	20495318

Showing 1 to 1 of 1 entries

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Patents

Sample Use Guides

In Vivo Use Guide

injections of oxycodone and hydrocotarnine contains 8 mg of oxycodone hydrochloride and 2 mg of hydrocotarnine hydrochloride.

Route of Administration: Other

In Vitro Use Guide

Hydrocotarnine (0.000388–38.8 mM) did not induce a significant change in the metabolic activities of CYP2C9, 2C19, and 2E1. Although weak inhibitory effects were observed on CYP3A4 and 2D6, the inhibition rate was less than 50% at the concentrations below 3.88 mM.

Show entries

Name

Type

Language

HYDROCOTARNINE

Common Name

English

8-METHOXY-5,6-METHYLENEDIOXY-2-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE

Systematic Name

English

Hydrocotarnine [WHO-DD]

Common Name