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Details

Stereochemistry ACHIRAL
Molecular Formula C12H15NO3.BrH
Molecular Weight 302.164
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HYDROCOTARNINE HYDROBROMIDE

SMILES

Br.COC1=C2OCOC2=CC3=C1CN(C)CC3

InChI

InChIKey=VMLDPXIOBIJNAW-UHFFFAOYSA-N
InChI=1S/C12H15NO3.BrH/c1-13-4-3-8-5-10-12(16-7-15-10)11(14-2)9(8)6-13;/h5H,3-4,6-7H2,1-2H3;1H

HIDE SMILES / InChI
Molecular Formula C12H15NO3
Molecular Weight 221.2524
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula BrH
Molecular Weight 80.912
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including: https://www.ncbi.nlm.nih.gov/pubmed/19252340

Hydrocotarnine is a crystalline alkaloid, obtained from opium and also formed by the reduction of cotarnine. It is a non-narcotic opium alkaloid. Hydrocotarnine is supposed to potentiate the analgesic effect of oxycodone with unknown mechanism.

CNS Activity

CNS Penetrant
2554
Curator's Comment: The tests were performed at different time periods (5, 15, 45 and 120 min) after male and female Wistar rats were treated with seized heroin. Seized heroin contained a mixture of opiate alkaloids, including hydrocotarnine. Opiate alkaloids were quantitatively determined in brain regions known for their high concentration of µ-opiate receptors: cortex, brainstem, amygdala and basal ganglia. Human data not available.

Originator

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
 18.4 µM [IC50]
Inhibitor
8297
 6.63 µM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
Unknown

Approved Use

Compound injection of oxycodone and hydrocotarnine is effective for cancer pain treatment
PubMed

PubMed

TitleDatePubMed
Determination of oxycodone and hydrocotarnine in cancer patient serum by high-performance liquid chromatography with electrochemical detection.
2005 Mar
Comparison of the various opiate alkaloid contaminants and their metabolites found in illicit heroin with 6-monoacetyl morphine as indicators of heroin ingestion.
2006 May
[Conversion ratio between intravenous oxycodone/hydrocotarnine and sustained-release oral oxycodone in patients with cancer pain].
2007 Dec
Pharmacokinetics and variation in the clearance of oxycodone and hydrocotarnine in patients with cancer pain.
2007 Nov
Effect of hydrocotarnine on cytochrome P450 and P-glycoprotein.
2009
[Efficacy and safety of continuous subcutaneous injection of the compound oxycodone in cancer pain management: the first 4-year audit].
2009 Oct
[Efficacy and safety of compound oxycodone injection for cancer pain relief-a multicenter survey of prescriptions].
2010 May
Patents

Patents

04769480
6
20030039699
8
20090269772
13
7192608
6

Sample Use Guides

In Vivo Use Guide
injections of oxycodone and hydrocotarnine contains 8 mg of oxycodone hydrochloride and 2 mg of hydrocotarnine hydrochloride.
Route of Administration: Other
In Vitro Use Guide
Hydrocotarnine (0.000388–38.8 mM) did not induce a significant change in the metabolic activities of CYP2C9, 2C19, and 2E1. Although weak inhibitory effects were observed on CYP3A4 and 2D6, the inhibition rate was less than 50% at the concentrations below 3.88 mM.
Substance Class Chemical
Created
by admin
on Sat Dec 16 01:15:12 GMT 2023
Edited
by admin
on Sat Dec 16 01:15:12 GMT 2023
Record UNII
XSR2NNV6TM
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HYDROCOTARNINE HYDROBROMIDE
MI  
Common Name English
HYDROCOTARNINE HYDROBROMIDE [MI]
Common Name English
5,6,7,8-TETRAHYDRO-4-METHOXY-6-METHYL-1,3-DIOXOLO(4,5-G)ISOQUINOLINE HYDROBROMIDE
Systematic Name English
NSC-99784
Code English
8-METHOXY-5,6-METHYLENEDIOXY-2-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROBROMIDE
Systematic Name English
1,3-DIOXOLO(4,5-G)ISOQUINOLINE, 5,6,7,8-TETRAHYDRO-4-METHOXY-6-METHYL-, HYDROBROMIDE (1:1)
Systematic Name English
Code System Code Type Description
FDA UNII
XSR2NNV6TM
Created by admin on Sat Dec 16 01:15:12 GMT 2023 , Edited by admin on Sat Dec 16 01:15:12 GMT 2023
PRIMARY
CAS
5985-00-2
Created by admin on Sat Dec 16 01:15:12 GMT 2023 , Edited by admin on Sat Dec 16 01:15:12 GMT 2023
PRIMARY
NSC
99784
Created by admin on Sat Dec 16 01:15:12 GMT 2023 , Edited by admin on Sat Dec 16 01:15:12 GMT 2023
PRIMARY
EPA CompTox
DTXSID9045392
Created by admin on Sat Dec 16 01:15:12 GMT 2023 , Edited by admin on Sat Dec 16 01:15:12 GMT 2023
PRIMARY
PUBCHEM
5459345
Created by admin on Sat Dec 16 01:15:12 GMT 2023 , Edited by admin on Sat Dec 16 01:15:12 GMT 2023
PRIMARY
MERCK INDEX
m6095
Created by admin on Sat Dec 16 01:15:12 GMT 2023 , Edited by admin on Sat Dec 16 01:15:12 GMT 2023
PRIMARY Merck Index
MESH
C024594
Created by admin on Sat Dec 16 01:15:12 GMT 2023 , Edited by admin on Sat Dec 16 01:15:12 GMT 2023
PRIMARY
Related Record Type Details
Structure of HYDROCOTARNINE
PARENT -> SALT/SOLVATE
NIH
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