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Details

Stereochemistry ACHIRAL
Molecular Formula C14H6Cl2F4N2O2
Molecular Weight 381.109
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TEFLUBENZURON

SMILES

FC1=CC=CC(F)=C1C(=O)NC(=O)NC2=C(F)C(Cl)=C(F)C(Cl)=C2

InChI

InChIKey=CJDWRQLODFKPEL-UHFFFAOYSA-N
InChI=1S/C14H6Cl2F4N2O2/c15-5-4-8(12(20)10(16)11(5)19)21-14(24)22-13(23)9-6(17)2-1-3-7(9)18/h1-4H,(H2,21,22,23,24)

HIDE SMILES / InChI

Description
Curator's Comment: Description was created based on several sources, including http://www.fluoridealert.org/wp-content/pesticides/teflubenzuron.scotlandepa99.pdf | http://apps.sepa.org.uk/spripa/Pages/SubstanceInformation.aspx?pid=173

Teflubenzuron is an insecticide which inhibits the biochemical synthesis of chitin. It controls all immature stages of the insects; the youngest larvae are the most susceptible and less teflubenzuron needs to be applied to control young larvae than older ones. The insecticidal activity of teflubenzuron results primarily from the ingestion of treated foliage; contact activity is less significant. The compound is also ovicidal by topical application. Teflubenzuron is used to control a wide range of insect pests and mites in fruit, vegetable, cereal and seed crops. It is also occasionally used to control sealice infestations in salmon.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
CALICIDE

Approved Use

Calicide (active ingredient Teflubenzuron) is a new in-feed sea lice treatment chemical for use by the marine salmon farming industry.

Launch Date

8.7298559E11
PubMed

PubMed

TitleDatePubMed
Transformation of the insecticide teflubenzuron by microorganisms.
2001 Sep
Field trials in Norway with SLICE (0.2% emamectin benzoate) for the oral treatment of sea lice infestation in farmed Atlantic salmon Salmo salar.
2002 Jun 21
Novaluron (Rimon), a novel IGR: potency and cross-resistance.
2003 Dec
Influence of a short exposure to teflubenzuron residues on the predation of thrips by Iphiseius degenerans (Acari: Phytoseiidae) and Orius laevigatus (Hemiptera: Anthocoridae).
2003 Nov
Determination of seven benzoylphenylurea insecticides in processed fruit and vegetables using high-performance liquid chromatography/tandem mass spectrometry.
2005
Hazards and uptake of chitin synthesis inhibitors in bumblebees Bombus terrestris.
2006 Aug
Effects of insect growth regulators on the nontarget soil arthropod Folsomia candida (Collembola).
2006 Feb
Historical control clinical trial to assess the effectiveness of teflubenzuron for treating sea lice on Atlantic salmon.
2006 Jun 12
Randomized clinical trial to investigate the effectiveness of teflubenzuron for treating sea lice on Atlantic salmon.
2006 Jun 12
Laboratory evaluation of five chitin synthesis inhibitors against the colorado potato beetle, Leptinotarsa decemlineata.
2007
Multigeneration effects of insect growth regulators on the springtail Folsomia candida.
2007 Jun
Insecticidal resistance and cross-resistance in populations of Cydia pomonella (Lepidoptera: Tortricidae) in central Europe.
2007 Oct
Determination of benzoylurea insecticide residues in tomatoes by high-performance liquid chromatography with ultraviolet-diode array and atmospheric pressure chemical ionization-mass spectrometry detection.
2007 Sep-Oct
Solid-phase microextraction for the determination of benzoylureas in orange juice using liquid chromatography combined with post-column photochemically induced fluorimetry derivatization and fluorescence detection.
2008 Jan
[Determination of benzoylurea and bishydrazide pesticide residues in vegetables by ultra performance liquid chromatography-tandem mass spectrometry with matrix solid phase dispersion].
2010 Apr
N-Benzoyl-N'-phenyl-urea.
2010 Jan 20
The effect of chitin metabolic effectors on the population increase of stored product mites.
2010 Oct
Field evaluation of pyriproxyfen and spinosad mixture for the control of insecticide resistant Aedes aegypti in Martinique (French West Indies).
2010 Sep 16
Patents

Sample Use Guides

Teflubenzuron (Calicide) is effective for the treatment of farmed Atlantic salmon Salmo salar L. infested with sea lice Lepeophtheirus salmonis (Krøyer, 1838) at a dose of 10mg/kg body weight per day for 7 consecutive days
Route of Administration: Oral
Teflubenzuron efficacy against Trichodina spp., was assessed using the concentrations of 30.0 or 50.0 mg/l for one hour exposure in tilapia, and the concentration of 30.0, 50.0 and 80.0 mg/l for one hour and 50 mg/l for two hours exposures in pacu. The drug effectiveness was observed against four identified Trichodina species: T. magna, T. heterodentata, T. compacta and T. centrostrigeata, with 87.9% parasite reduction with one hour exposure to 50.0 mg/l Teflubenzuron on O. niloticus and 96.1% with two hours exposure to 50.0 mg/l TFB on P. mesopotamicus.
Name Type Language
TEFLUBENZURON
ISO   MI  
Common Name English
TEFLUBENZURON [MI]
Common Name English
CME-134
Code English
TEFLUBENZURON [ISO]
Common Name English
NSC-367306
Code English
1-(3,5-DICHLORO-2,4-DIFLUOROPHENYL)-3-(2,6-DIFLUOROBENZOYL)UREA
Systematic Name English
N-(((3,5-DICHLORO-2,4-DIFLUOROPHENYL)AMINO)CARBONYL)-2,6-DIFLUOROBENZAMIDE
Systematic Name English
NOMOLT
Brand Name English
Classification Tree Code System Code
WHO-VATC QP53BC03
Created by admin on Fri Dec 15 18:06:42 UTC 2023 , Edited by admin on Fri Dec 15 18:06:42 UTC 2023
EPA PESTICIDE CODE 129048
Created by admin on Fri Dec 15 18:06:42 UTC 2023 , Edited by admin on Fri Dec 15 18:06:42 UTC 2023
Code System Code Type Description
PUBCHEM
91734
Created by admin on Fri Dec 15 18:06:42 UTC 2023 , Edited by admin on Fri Dec 15 18:06:42 UTC 2023
PRIMARY
EPA CompTox
DTXSID6042440
Created by admin on Fri Dec 15 18:06:42 UTC 2023 , Edited by admin on Fri Dec 15 18:06:42 UTC 2023
PRIMARY
CAS
83121-18-0
Created by admin on Fri Dec 15 18:06:42 UTC 2023 , Edited by admin on Fri Dec 15 18:06:42 UTC 2023
PRIMARY
CHEBI
39387
Created by admin on Fri Dec 15 18:06:42 UTC 2023 , Edited by admin on Fri Dec 15 18:06:42 UTC 2023
PRIMARY
MERCK INDEX
m10519
Created by admin on Fri Dec 15 18:06:42 UTC 2023 , Edited by admin on Fri Dec 15 18:06:42 UTC 2023
PRIMARY Merck Index
NSC
367306
Created by admin on Fri Dec 15 18:06:42 UTC 2023 , Edited by admin on Fri Dec 15 18:06:42 UTC 2023
PRIMARY
SMS_ID
100000156625
Created by admin on Fri Dec 15 18:06:42 UTC 2023 , Edited by admin on Fri Dec 15 18:06:42 UTC 2023
PRIMARY
EVMPD
SUB130601
Created by admin on Fri Dec 15 18:06:42 UTC 2023 , Edited by admin on Fri Dec 15 18:06:42 UTC 2023
PRIMARY
FDA UNII
FS9P57VL74
Created by admin on Fri Dec 15 18:06:42 UTC 2023 , Edited by admin on Fri Dec 15 18:06:42 UTC 2023
PRIMARY
ALANWOOD
teflubenzuron
Created by admin on Fri Dec 15 18:06:42 UTC 2023 , Edited by admin on Fri Dec 15 18:06:42 UTC 2023
PRIMARY