Details
Stereochemistry | ACHIRAL |
Molecular Formula | C14H6Cl2F4N2O2 |
Molecular Weight | 381.109 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
FC1=CC=CC(F)=C1C(=O)NC(=O)NC2=C(F)C(Cl)=C(F)C(Cl)=C2
InChI
InChIKey=CJDWRQLODFKPEL-UHFFFAOYSA-N
InChI=1S/C14H6Cl2F4N2O2/c15-5-4-8(12(20)10(16)11(5)19)21-14(24)22-13(23)9-6(17)2-1-3-7(9)18/h1-4H,(H2,21,22,23,24)
Molecular Formula | C14H6Cl2F4N2O2 |
Molecular Weight | 381.109 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: http://www.fao.org/fileadmin/templates/agphome/documents/Pests_Pesticides/JMPR/Evaluation96/tefluben.pdfCurator's Comment: Description was created based on several sources, including
http://www.fluoridealert.org/wp-content/pesticides/teflubenzuron.scotlandepa99.pdf | http://apps.sepa.org.uk/spripa/Pages/SubstanceInformation.aspx?pid=173
Sources: http://www.fao.org/fileadmin/templates/agphome/documents/Pests_Pesticides/JMPR/Evaluation96/tefluben.pdf
Curator's Comment: Description was created based on several sources, including
http://www.fluoridealert.org/wp-content/pesticides/teflubenzuron.scotlandepa99.pdf | http://apps.sepa.org.uk/spripa/Pages/SubstanceInformation.aspx?pid=173
Teflubenzuron is an insecticide which inhibits the biochemical synthesis of chitin. It controls all immature stages of the insects; the youngest larvae are the most susceptible and less teflubenzuron needs to be applied to control young larvae than older ones. The insecticidal activity of teflubenzuron results primarily from the ingestion of treated foliage; contact activity is less significant. The compound is also ovicidal by topical application. Teflubenzuron is used to control a wide range of insect pests and mites in fruit, vegetable, cereal and seed crops. It is also occasionally used to control sealice infestations in salmon.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Curative | CALICIDE Approved UseCalicide (active ingredient Teflubenzuron) is a new in-feed sea lice treatment chemical for use by the marine salmon farming industry. Launch Date1997 |
PubMed
Title | Date | PubMed |
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Field trials in Norway with SLICE (0.2% emamectin benzoate) for the oral treatment of sea lice infestation in farmed Atlantic salmon Salmo salar. | 2002 Jun 21 |
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Age-dependent response to insecticides and enzymatic variation in susceptible and resistant codling moth larvae. | 2002 Oct |
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Toxicological efficacy of some indigenous dill compounds against the flesh fly, Parasarcophaga dux Thomson. | 2004 Apr |
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Compatibility of the entomopathogenic fungus Lecanicillium muscarium and insecticides for eradication of sweetpotato whitefly, Bemisia tabaci. | 2005 Aug |
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Historical control clinical trial to assess the effectiveness of teflubenzuron for treating sea lice on Atlantic salmon. | 2006 Jun 12 |
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Randomized clinical trial to investigate the effectiveness of teflubenzuron for treating sea lice on Atlantic salmon. | 2006 Jun 12 |
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Laboratory evaluation of five chitin synthesis inhibitors against the colorado potato beetle, Leptinotarsa decemlineata. | 2007 |
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Compatibility of Verticillium lecani (Zimm.) with several pesticides. | 2007 |
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Safe apples for baby-food production: survey of pesticide treatment regimes leaving minimum residues. | 2007 Jun |
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Multigeneration effects of insect growth regulators on the springtail Folsomia candida. | 2007 Jun |
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Insecticidal resistance and cross-resistance in populations of Cydia pomonella (Lepidoptera: Tortricidae) in central Europe. | 2007 Oct |
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Different transcript patterns in response to specialist and generalist herbivores in the wild Arabidopsis relative Boechera divaricarpa. | 2007 Oct 24 |
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Determination of benzoylurea insecticide residues in tomatoes by high-performance liquid chromatography with ultraviolet-diode array and atmospheric pressure chemical ionization-mass spectrometry detection. | 2007 Sep-Oct |
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The efficacy of emamectin benzoate against infestations of Lepeophtheirus salmonis on farmed Atlantic salmon (Salmo salar L) in Scotland, 2002-2006. | 2008 Feb 6 |
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Solid-phase microextraction for the determination of benzoylureas in orange juice using liquid chromatography combined with post-column photochemically induced fluorimetry derivatization and fluorescence detection. | 2008 Jan |
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Side effects of teflubenzuron and chlorfenapyr in Eriopis connexa eggs (Coleoptera: Coccinellidae). | 2009 |
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[Determination of benzoylurea and bishydrazide pesticide residues in vegetables by ultra performance liquid chromatography-tandem mass spectrometry with matrix solid phase dispersion]. | 2010 Apr |
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N-Benzoyl-N'-phenyl-urea. | 2010 Jan 20 |
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The effect of chitin metabolic effectors on the population increase of stored product mites. | 2010 Oct |
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Field evaluation of pyriproxyfen and spinosad mixture for the control of insecticide resistant Aedes aegypti in Martinique (French West Indies). | 2010 Sep 16 |
Sample Use Guides
Teflubenzuron (Calicide) is effective for the treatment of farmed Atlantic salmon Salmo salar L. infested with sea lice Lepeophtheirus salmonis (Krøyer, 1838) at a dose of 10mg/kg body weight per day for 7 consecutive days
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25913667
Teflubenzuron efficacy against Trichodina spp., was assessed using the concentrations of 30.0 or 50.0 mg/l for one hour exposure in tilapia, and the concentration of 30.0, 50.0 and 80.0 mg/l for one hour and 50 mg/l for two hours exposures in pacu. The drug effectiveness was observed against four identified Trichodina species: T. magna, T. heterodentata, T. compacta and T. centrostrigeata, with 87.9% parasite reduction with one hour exposure to 50.0 mg/l Teflubenzuron on O. niloticus and 96.1% with two hours exposure to 50.0 mg/l TFB on P. mesopotamicus.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 18:06:42 GMT 2023
by
admin
on
Fri Dec 15 18:06:42 GMT 2023
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Record UNII |
FS9P57VL74
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Record Status |
Validated (UNII)
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Record Version |
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WHO-VATC |
QP53BC03
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EPA PESTICIDE CODE |
129048
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teflubenzuron
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