TETRAZEPAM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H17ClN2O
Molecular Weight	288.772
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C2=C(C=C(Cl)C=C2)C(=NCC1=O)C3=CCCCC3

InChI

InChIKey=IQWYAQCHYZHJOS-UHFFFAOYSA-N

InChI=1S/C16H17ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h5,7-9H,2-4,6,10H2,1H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/24845943 | https://www.ncbi.nlm.nih.gov/pubmed/26012498

Tetrazepam was the most widely prescribed muscle relaxant in Germany. After a series of studies, which have shown, that tetrazepam caused cutaneous adverse effects and toxic epidermal necrolysis, the drug was withdrawn from the market.

Approval Year

PubMed

Title	Date	PubMed
Direct injection micellar liquid chromatographic determination of benzodiazepines in serum.	2002 Nov 25	12401349
[Determination of benzodiazepine derivatives mixture by high performance liquid chromatography].	2003	14617855
Screening, library-assisted identification and validated quantification of 23 benzodiazepines, flumazenil, zaleplone, zolpidem and zopiclone in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization.	2004 Aug	15329838
[Drug Safety. Preventing medication errors].	2004 Jul-Aug	15369443
Medicinal and injection therapies for mechanical neck disorders.	2005 Apr 18	15846603
Screening method for benzodiazepines and hypnotics in hair at pg/mg level by liquid chromatography-mass spectrometry/mass spectrometry.	2005 Oct 15	16154525
[Current differential diagnosis of hypereosinophilic syndrome].	2007 Nov-Dec	18666600
Systemic dermatitis due to tetrazepam.	2008	18973107
Acute generalized exanthematous pustulosis due to tetrazepam.	2008	18447141
Lumbar spondylosis: clinical presentation and treatment approaches.	2009 Jun	19468872
Occupational airborne contact allergy to tetrazepam in a geriatric nurse.	2009 Oct	19453384
Drugs associated with more suicidal ideations are also associated with more suicide attempts.	2009 Oct 2	19798416
The impact of perfectionism and anxiety traits on action monitoring in major depressive disorder.	2010 Jul	20473695

Patents

Sample Use Guides

In Vivo Use Guide

Tetrazepam was given orally as a single dose of 50 mg and repeated administration for 5 consecutive days of 50 mg at 12-h intervals, in tablet form

Route of Administration: Oral

Name

Type

Language

TETRAZEPAM

Official Name

English

Tetrazepam [WHO-DD]

Common Name

English

CB 4261

Code

English

tetrazepam [INN]

Common Name

English

TETRAZEPAM [EP MONOGRAPH]

Common Name

English

TETRAZEPAM [MART.]

Common Name

English

MYOLASTAN

Brand Name

English

CB-4261

Code

English

TETRAZEPAM [MI]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QM03BX07