U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C16H17ClN2O
Molecular Weight 288.772
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TETRAZEPAM

SMILES

CN1C2=C(C=C(Cl)C=C2)C(=NCC1=O)C3=CCCCC3

InChI

InChIKey=IQWYAQCHYZHJOS-UHFFFAOYSA-N
InChI=1S/C16H17ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h5,7-9H,2-4,6,10H2,1H3

HIDE SMILES / InChI
Tetrazepam was the most widely prescribed muscle relaxant in Germany. After a series of studies, which have shown, that tetrazepam caused cutaneous adverse effects and toxic epidermal necrolysis, the drug was withdrawn from the market.

Approval Year

PubMed

PubMed

TitleDatePubMed
Adverse reaction to tetrazepam.
2001
The usefulness of patch testing on the previously most severely affected site in a cutaneous adverse drug reaction to tetrazepam.
2001 Apr
Guidelines for performing skin tests with drugs in the investigation of cutaneous adverse drug reactions.
2001 Dec
Development of a novel parenteral formulation for tetrazepam using a lipid emulsion.
2001 Nov
[Medical treatment of spasticity].
2003 May
Sex-dependent modulation of treatment response.
2004 Mar
Screening and confirmatory method for benzodiazepines and hypnotics in oral fluid by LC-MS/MS.
2005 Jun 10
Development of in situ ion selective sensors for dissolution.
2007 Jan 2
[Current differential diagnosis of hypereosinophilic syndrome].
2007 Nov-Dec
Systemic dermatitis due to tetrazepam.
2008
Patch testing in non-immediate drug eruptions.
2008 Jun 15
Metabolic studies of tetrazepam based on electrochemical simulation in comparison to in vivo and in vitro methods.
2009 Apr 10
Drugs associated with more suicidal ideations are also associated with more suicide attempts.
2009 Oct 2
Development and validation of an EI-GC-MS method for the determination of benzodiazepine drugs and their metabolites in blood: applications in clinical and forensic toxicology.
2010 Aug 1
Solubilization of poorly water-soluble drugs by mixed micelles based on hydrogenated phosphatidylcholine.
2010 Aug 16
An updated overview of clinical guidelines for the management of non-specific low back pain in primary care.
2010 Dec
The impact of perfectionism and anxiety traits on action monitoring in major depressive disorder.
2010 Jul
Patient-reported-outcomes in subjects with painful lumbar or cervical radiculopathy treated with pregabalin: evidence from medical practice in primary care settings.
2010 Jun
[Multimodal treatment of chronic unspecific low back pain].
2010 Mar-Apr
Occupational allergic contact dermatitis from tetrazepam in nurses.
2010 May
Experimental design for optimization of microwave-assisted extraction of benzodiazepines in human plasma.
2010 May
Analysis of six benzodiazepines in vitreous humor by high-performance liquid chromatography-photodiode-array detection.
2010 Nov
Patents

Sample Use Guides

Tetrazepam was given orally as a single dose of 50 mg and repeated administration for 5 consecutive days of 50 mg at 12-h intervals, in tablet form
Route of Administration: Oral
Name Type Language
TETRAZEPAM
EP   INN   MART.   MI   WHO-DD  
INN  
Official Name English
Tetrazepam [WHO-DD]
Common Name English
CB 4261
Code English
tetrazepam [INN]
Common Name English
TETRAZEPAM [EP MONOGRAPH]
Common Name English
TETRAZEPAM [MART.]
Common Name English
MYOLASTAN
Brand Name English
CB-4261
Code English
TETRAZEPAM [MI]
Common Name English
Classification Tree Code System Code
WHO-VATC QM03BX07
Created by admin on Fri Dec 16 17:11:35 UTC 2022 , Edited by admin on Fri Dec 16 17:11:35 UTC 2022
WHO-ATC M03BX07
Created by admin on Fri Dec 16 17:11:34 UTC 2022 , Edited by admin on Fri Dec 16 17:11:34 UTC 2022
DEA NO. 2886
Created by admin on Fri Dec 16 17:11:34 UTC 2022 , Edited by admin on Fri Dec 16 17:11:34 UTC 2022
NCI_THESAURUS C1012
Created by admin on Fri Dec 16 17:11:35 UTC 2022 , Edited by admin on Fri Dec 16 17:11:35 UTC 2022
Code System Code Type Description
INN
2182
Created by admin on Fri Dec 16 17:11:34 UTC 2022 , Edited by admin on Fri Dec 16 17:11:34 UTC 2022
PRIMARY
DRUG CENTRAL
2614
Created by admin on Fri Dec 16 17:11:34 UTC 2022 , Edited by admin on Fri Dec 16 17:11:34 UTC 2022
PRIMARY
ChEMBL
CHEMBL2105527
Created by admin on Fri Dec 16 17:11:34 UTC 2022 , Edited by admin on Fri Dec 16 17:11:34 UTC 2022
PRIMARY
MERCK INDEX
M10661
Created by admin on Fri Dec 16 17:11:34 UTC 2022 , Edited by admin on Fri Dec 16 17:11:34 UTC 2022
PRIMARY Merck Index
FDA UNII
FO92091VP8
Created by admin on Fri Dec 16 17:11:34 UTC 2022 , Edited by admin on Fri Dec 16 17:11:34 UTC 2022
PRIMARY
PUBCHEM
25215
Created by admin on Fri Dec 16 17:11:35 UTC 2022 , Edited by admin on Fri Dec 16 17:11:35 UTC 2022
PRIMARY
DRUG BANK
DB13324
Created by admin on Fri Dec 16 17:11:34 UTC 2022 , Edited by admin on Fri Dec 16 17:11:34 UTC 2022
PRIMARY
WIKIPEDIA
TETRAZEPAM
Created by admin on Fri Dec 16 17:11:35 UTC 2022 , Edited by admin on Fri Dec 16 17:11:35 UTC 2022
PRIMARY
EVMPD
SUB10946MIG
Created by admin on Fri Dec 16 17:11:34 UTC 2022 , Edited by admin on Fri Dec 16 17:11:34 UTC 2022
PRIMARY
CAS
10379-14-3
Created by admin on Fri Dec 16 17:11:34 UTC 2022 , Edited by admin on Fri Dec 16 17:11:34 UTC 2022
PRIMARY
NCI_THESAURUS
C74282
Created by admin on Fri Dec 16 17:11:35 UTC 2022 , Edited by admin on Fri Dec 16 17:11:35 UTC 2022
PRIMARY
EPA CompTox
DTXSID00146058
Created by admin on Fri Dec 16 17:11:34 UTC 2022 , Edited by admin on Fri Dec 16 17:11:34 UTC 2022
PRIMARY
ECHA (EC/EINECS)
233-837-7
Created by admin on Fri Dec 16 17:11:34 UTC 2022 , Edited by admin on Fri Dec 16 17:11:34 UTC 2022
PRIMARY
RXCUI
37985
Created by admin on Fri Dec 16 17:11:35 UTC 2022 , Edited by admin on Fri Dec 16 17:11:35 UTC 2022
PRIMARY RxNorm
MESH
C005245
Created by admin on Fri Dec 16 17:11:35 UTC 2022 , Edited by admin on Fri Dec 16 17:11:35 UTC 2022
PRIMARY