TETRAZEPAM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H17ClN2O
Molecular Weight	288.772
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C2=C(C=C(Cl)C=C2)C(=NCC1=O)C3=CCCCC3

InChI

InChIKey=IQWYAQCHYZHJOS-UHFFFAOYSA-N

InChI=1S/C16H17ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h5,7-9H,2-4,6,10H2,1H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/24845943 | https://www.ncbi.nlm.nih.gov/pubmed/26012498

Tetrazepam was the most widely prescribed muscle relaxant in Germany. After a series of studies, which have shown, that tetrazepam caused cutaneous adverse effects and toxic epidermal necrolysis, the drug was withdrawn from the market.

Approval Year

PubMed

Title	Date	PubMed
[Analysis of benzodiazepine derivative mixture by gas-liquid chromatography].	2002	12474705
Formulating and stability of benzodiazepines in a new lipid emulsion formulation.	2002 Nov	12611276
Tetrazepam drug sensitivity -- usefulness of the patch test.	2002 Sep	12492544
Occupational airborne contact allergy to tetrazepam.	2003 Nov	14996051
[Drug Safety. Preventing medication errors].	2004 Jul-Aug	15369443
Sex-dependent modulation of treatment response.	2004 Mar	22034399
Medicinal and injection therapies for mechanical neck disorders.	2005 Apr 18	15846603
Occupational airborne contact dermatitis from sporadic exposure to tetrazepam during machine maintenance.	2005 Mar	15811045
Acute generalized exanthematous pustulosis due to tetrazepam.	2008	18447141
Metabolic studies of tetrazepam based on electrochemical simulation in comparison to in vivo and in vitro methods.	2009 Apr 10	19233363
No cross-reactions between tetrazepam and other benzodiazepines: a possible chemical explanation.	2009 Jul	19659970
Lumbar spondylosis: clinical presentation and treatment approaches.	2009 Jun	19468872
Drugs associated with more suicidal ideations are also associated with more suicide attempts.	2009 Oct 2	19798416
Solubilization of poorly water-soluble drugs by mixed micelles based on hydrogenated phosphatidylcholine.	2010 Aug 16	20580793
An updated overview of clinical guidelines for the management of non-specific low back pain in primary care.	2010 Dec	20602122
Assessment of abuse potential of benzodiazepines from a prescription database using 'doctor shopping' as an indicator.	2010 Jul	20527997
Patient-reported-outcomes in subjects with painful lumbar or cervical radiculopathy treated with pregabalin: evidence from medical practice in primary care settings.	2010 Jun	19798503
[Multimodal treatment of chronic unspecific low back pain].	2010 Mar-Apr	20831016
Experimental design for optimization of microwave-assisted extraction of benzodiazepines in human plasma.	2010 May	20204329
Analysis of six benzodiazepines in vitreous humor by high-performance liquid chromatography-photodiode-array detection.	2010 Nov	21073805

Patents

Sample Use Guides

In Vivo Use Guide

Tetrazepam was given orally as a single dose of 50 mg and repeated administration for 5 consecutive days of 50 mg at 12-h intervals, in tablet form

Route of Administration: Oral

Name

Type

Language

TETRAZEPAM

Official Name

English

Tetrazepam [WHO-DD]

Common Name

English

CB 4261

Code

English

tetrazepam [INN]

Common Name

English

TETRAZEPAM [EP MONOGRAPH]

Common Name

English

TETRAZEPAM [MART.]

Common Name

English

MYOLASTAN

Brand Name

English

CB-4261

Code

English

TETRAZEPAM [MI]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QM03BX07