FLUROXENE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C4H5F3O
Molecular Weight	126.0771
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

FC(F)(F)COC=C

InChI

InChIKey=DLEGDLSLRSOURQ-UHFFFAOYSA-N

InChI=1S/C4H5F3O/c1-2-8-3-4(5,6)7/h2H,1,3H2

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Description

FLUROXENE (Fluoromar®) is a colorless, volatile liquid, which was used as an inhalational anesthetic.

CNS Activity

Approval Year

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 614	Primary		Approved 8,429	Fluoromar

Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
P450 1	P450 3

Drug as perpetrator

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Target	Modality	Activity	Metabolite	Clinical evidence
P450 1	inhibitor 3,277	yes

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Drug as victim

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Target	Modality	Activity	Metabolite	Clinical evidence
P450 3	substrate 3,367	yes

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Sourcing

Sourcing

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Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B3-032275	http://www.3bsc.com/index/pro_info.php?id=53539
AA Blocks	AA003F4J	https://www.aablocks.com/goods/Goods/detail?id=AA003F4J
AEchem Scientific Corp., USA	AE054527	https://www.aechemsc.com/info_products/AE054527.php
AHH Chemical co.,ltd	MT-30734	http://www.ahhchemical.com/product/MT-30734.html
AK Scientific, Inc. (AKSCI)	X2021	http://www.aksci.com/item_detail.php?cat=X2021

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PubMed

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Title	Date	PubMed
Electroencephalographic seizure activity in dogs during anaesthesia.	1971 Aug	4398198
The effect of enflurane, isoflurane, fluroxene, methoxyflurane and diethyl ether anesthesia on ouabain tolerance in the dog.	1976 May-Jun	5922
Cardiovascular effects of pancuronium in patients anaesthetized with enflurane and fluroxene.	1981 Jan	6113039
Cross-approximate entropy of cortical local field potentials quantifies effects of anesthesia--a pilot study in rats.	2010 Sep 23	20863382

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Patents

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Name

Type

Language

FLUROXENE

Official Name

English

ETHENE, (2,2,2-TRIFLUOROETHOXY)-

Systematic Name

English

2,2,2-Trifluoroethyl vinyl ether

Systematic Name

English

Fluroxene [WHO-DD]

Common Name

English

FLUROXENE [USAN]

Common Name

English

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Classification Tree

Code System

Code

Agent Affecting Nervous System

NCI_THESAURUS

C245

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Code System

Code

Type

Description

FDA UNII

FO7JHA3G03

PRIMARY

PUBCHEM

9844

PRIMARY

MESH

C084587

PRIMARY

NSC

760364

PRIMARY

SMS_ID

100000080951

PRIMARY

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ACTIVE MOIETY


					FO7JHA3G03

FLUROXENE

SMILES

InChI

CNS Activity

Approval Year

Conditions

Overview

OverviewOther

Drug as perpetrator​

Drug as victim

Sourcing

PubMed

Patents

Drug as perpetrator