FLUROXENE

US Previously Marketed

First approved in 1954

Details

Stereochemistry	ACHIRAL
Molecular Formula	C4H5F3O
Molecular Weight	126.0771
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC(F)(F)COC=C

InChI

InChIKey=DLEGDLSLRSOURQ-UHFFFAOYSA-N

InChI=1S/C4H5F3O/c1-2-8-3-4(5,6)7/h2H,1,3H2

HIDE SMILES / InChI

Description
Sources: https://www.drugfuture.com/chemdata/fluroxene.html | https://www.ncbi.nlm.nih.gov/pubmed/13420163

FLUROXENE (Fluoromar®) is a colorless, volatile liquid, which was used as an inhalational anesthetic.

CNS Activity

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 614 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4379664 http://www.drugfuture.com/chemdata/fluroxene.html	Primary		Approved 8429	Fluoromar Approved Use Formerly as anesthetic (inhalation). Launch Date 1960

Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
P450 1	P450 3

Drug as perpetrator

Target	Modality	Activity	Metabolite	Clinical evidence
P450 1	inhibitor 3277 Sources: https://accessmedicine.mhmedical.com/content.aspx?bookid=2249§ionid=175215930	yes

Drug as victim

Target	Modality	Activity	Metabolite	Clinical evidence
P450 3	substrate 3367 Sources: https://pubmed.ncbi.nlm.nih.gov/25763/	yes

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B3-032275	http://www.3bsc.com/index/pro_info.php?id=53539
AA Blocks	AA003F4J	https://www.aablocks.com/goods/Goods/detail?id=AA003F4J
AEchem Scientific Corp., USA	AE054527	https://www.aechemsc.com/info_products/AE054527.php
AHH Chemical co.,ltd	MT-30734	http://www.ahhchemical.com/product/MT-30734.html
AK Scientific, Inc. (AKSCI)	X2021	http://www.aksci.com/item_detail.php?cat=X2021
Acadechem	ACDS-034242	http://www.acadechemical.com/product/108941
Achemica	ACMC-1AFWH	http://www.achemica.com/prodinfo/?id=4254
Alichem	490025775	http://www.alichem.com/en/products/406-90-6.html
Ambinter	Amb10840029	http://www.ambinter.com/reference/10840029
Chem Scene	CS-4763	http://www.chemscene.com/406-90-6.html
ChemMol	99086774	http://www.chemmol.com/chemmol/99086774.html
Finetech	FT-0609045	http://www.finetechnology-ind.com/prod/detail/pub/406-90-6.html
Lab Network	LN01343393	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN01343393
MedChem Express	HY-B1163	https://www.medchemexpress.com/Fluroxene.html
MuseChem	I003485	https://www.musechem.com/product/I003485.html
Parchem	43693	https://www.parchem.com/chemical-supplier-distributor/2-2-2-Trifluoroethyl-vinyl-ether-043693.aspx
Sigma-Aldrich	697435_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/697435?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech	S018585	http://www.sinfoobiotech.com/product/1021983
Smolecule	S571733	https://www.smolecule.com/products/s571733
THE BioTek	bt-305307	https://www.thebiotek.com/product/others/bt-305307
Yuhao Chemical	LQ0815	http://www.chemyuhao.com/406-90-6.html
abcr GmbH	AB172162	http://www.abcr.com/shop/en/AB172162

PubMed

Title	Date	PubMed

Patents

Name

Type

Language

FLUROXENE

Official Name

English

ETHENE, (2,2,2-TRIFLUOROETHOXY)-

Systematic Name

English

2,2,2-Trifluoroethyl vinyl ether

Systematic Name

English

Fluroxene [WHO-DD]

Common Name

English

FLUROXENE [USAN]

Common Name

English

FLUROXENE [MI]

Common Name

English

FLUOROMAR

Brand Name

English

fluroxene [INN]

Common Name

English

NSC-760364

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C245