EXAPROLOL HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H29NO2.ClH
Molecular Weight	327.889
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC(C)NCC(O)COC1=C(C=CC=C1)C2CCCCC2

InChI

InChIKey=ODWXZMXQBDEIBF-UHFFFAOYSA-N

InChI=1S/C18H29NO2.ClH/c1-14(2)19-12-16(20)13-21-18-11-7-6-10-17(18)15-8-4-3-5-9-15;/h6-7,10-11,14-16,19-20H,3-5,8-9,12-13H2,1-2H3;1H

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8056 | https://www.ncbi.nlm.nih.gov/pubmed/6149283 | https://www.ncbi.nlm.nih.gov/pubmed/1695466 | https://www.ncbi.nlm.nih.gov/pubmed/6187191

Exaprolol is a non-selective antagonist at beta-adrenoceptors exerting antiarrhythmic and local anesthetic activity. It inhibits the inotropic and chronotropic responses. Exaprolol liberates histamine from isolated mast cells and decreases the uptake of extracellular histamine. It acts on mast cells due to the direct and indirect ion exchange mechanism resulted in disproportion between histamine and granule liberation.

Originator

Approval Year

PubMed

Title	Date	PubMed

Name

Type

Language

EXAPROLOL HYDROCHLORIDE

Official Name

English

EXAPROLOL HCL

Common Name

English

(±)-1-(O-CYCLOHEXYLPHENOXY)-3-(ISOPROPYLAMINO)-2-PROPANOL HYDROCHLORIDE

Common Name

English

Exaprolol hydrochloride [WHO-DD]

Common Name

English

MG-8823

Code

English

M.G. 8823

Code

English

EXAPROLOL HYDROCHLORIDE [USAN]

Common Name

English

NSC-297939

Code

English

2-PROPANOL, 1-(2-CYCLOHEXYLPHENOXY)-3-((1-METHYLETHYL)AMINO)-, HYDROCHLORIDE, (±)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29576