EXAPROLOL HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H29NO2.ClH
Molecular Weight	327.889
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC(C)NCC(O)COC1=C(C=CC=C1)C2CCCCC2

InChI

InChIKey=ODWXZMXQBDEIBF-UHFFFAOYSA-N

InChI=1S/C18H29NO2.ClH/c1-14(2)19-12-16(20)13-21-18-11-7-6-10-17(18)15-8-4-3-5-9-15;/h6-7,10-11,14-16,19-20H,3-5,8-9,12-13H2,1-2H3;1H

HIDE SMILES / InChI

Molecular Formula	C18H29NO2
Molecular Weight	291.4284
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8056 | https://www.ncbi.nlm.nih.gov/pubmed/6149283 | https://www.ncbi.nlm.nih.gov/pubmed/1695466 | https://www.ncbi.nlm.nih.gov/pubmed/6187191

Exaprolol is a non-selective antagonist at beta-adrenoceptors exerting antiarrhythmic and local anesthetic activity. It inhibits the inotropic and chronotropic responses. Exaprolol liberates histamine from isolated mast cells and decreases the uptake of extracellular histamine. It acts on mast cells due to the direct and indirect ion exchange mechanism resulted in disproportion between histamine and granule liberation.

Originator

Approval Year

PubMed

Title	Date	PubMed
Basic ethers of cyclohexylphenols with beta-blocking activity: synthesis and pharmacological study of exaprolol.	1976 Apr	8056
Aspects of the cardiovascular pharmacology of exaprolol.	1984 Sep	6149283
Histamine liberation as a result of nonreceptor interaction.	1990 Apr	1695466
PET imaging of beta-adrenoceptors in human brain: a realistic goal or a mirage?	2004	15134573
Synthesis and preliminary evaluation of (S)-[11C]-exaprolol, a novel beta-adrenoceptor ligand for PET.	2008 Mar-Apr	17961850

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:26:17 GMT 2023` Edited by `admin` on `Fri Dec 15 16:26:17 GMT 2023`
Record UNII	FGT82HNC7L
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

EXAPROLOL HYDROCHLORIDE

Official Name

English

EXAPROLOL HCL

Common Name

English

(±)-1-(O-CYCLOHEXYLPHENOXY)-3-(ISOPROPYLAMINO)-2-PROPANOL HYDROCHLORIDE

Common Name

English

Exaprolol hydrochloride [WHO-DD]

Common Name

English

MG-8823

Code

English

M.G. 8823

Code

English

EXAPROLOL HYDROCHLORIDE [USAN]

Common Name

English

NSC-297939

Code

English

2-PROPANOL, 1-(2-CYCLOHEXYLPHENOXY)-3-((1-METHYLETHYL)AMINO)-, HYDROCHLORIDE, (±)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29576