U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C2H6O2
Molecular Weight 62.0678
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ETHYLENE GLYCOL

SMILES

OCCO

InChI

InChIKey=LYCAIKOWRPUZTN-UHFFFAOYSA-N
InChI=1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

HIDE SMILES / InChI

Description

Ethylene glycol is a useful industrial compound found in many consumer products, including automotive antifreeze, hydraulic brake fluids, some stamp pad inks, ballpoint pens, solvents, paints, plastics, films, and cosmetics; it also is used as a pharmaceutical vehicle. Ethylene glycol has a sweet taste and is often accidentally or intentionally ingested. Ethylene glycol is chemically broken down in the body into toxic compounds. It and its toxic byproducts first affect the central nervous system (CNS), then the heart, and finally the kidneys. Ingestion of sufficient amounts can be fatal. Ethylene glycol is odorless; odor does not provide any warning of inhalation exposure to hazardous concentrations.

CNS Activity

CNS Active
3913
Curator's Comment: Within the first few hours after ingestion, there is transient excitation followed by CNS depression.

Originator

Charles-Adolphe Wurtz
1
Curator's Comment: Ethylene Glycol was first prepared by a French chemist Charles-Adolphe Wurtz from ethylene glycol via saponification in the year 1859.

Approval Year

2003
176
PubMed

PubMed

TitleDatePubMed
[Ethylene glycole poisonings in Nothern Savo 1984-98].
2001
New approaches to developing lithium polymer batteries.
2001
Selective binding of albumin on stearyl poly(ethylene oxide) coupling polymer-modified poly(ether urethane) surfaces.
2001
Interaction of blood components with heparin-immobilized polyurethanes prepared by plasma glow discharge.
2001
Maximization of injection volumes for DNA analysis in capillary electrophoresis.
2001 Dec
The binding of difunctional neutral guest molecules by novel bis(tripyrrolyl) cryptands.
2001 Sep 7
Physicochemical properties and in vitro biocompatibility of PEO/PTMO multiblock copolymer/segmented polyurethane blends.
2002
Characterization of guided microwave spectrometry using water-ethanol mixtures.
2002
Determination of the structure of the organized phase of the block copolymer PEO-PPO-PEO in aqueous solutions under flow by small-angle neutron scattering.
2002 Apr
Calorimetric studies of diclofenac sodium in aqueous solution of cyclodextrin and water-ethanol mixtures.
2002 Apr
Hydrogels based on poly(ethylene oxide) and poly(tetramethylene oxide) or poly(dimethyl siloxane): synthesis, characterization, in vitro protein adsorption and platelet adhesion.
2002 Apr
Co-extrusion of biocompatible polymers for scaffolds with co-continuous morphology.
2002 Apr
Copper-psychoactive drug complexes: a voltammetric approach to complexation by 1,4-benzodiazepines.
2002 Apr 15
Multivalent interactions between biotin-polyrotaxane conjugates and streptavidin as a model of new targeting for transporters.
2002 Apr 23
Ab initio conformational studies on diols and binary diol-water systems using DFT methods. Intramolecular hydrogen bonding and 1:1 complex formation with water.
2002 Apr 30
Interaction of exogenous hypochlorite or hypochlorite produced by myeloperoxidase + H2O2 + Cl- system with unsaturated phosphatidylcholines.
2002 Aug
The impact of a plug of salts on the analysis of large volumes of dsDNA by capillary electrophoresis.
2002 Aug
Size-based separation of synthetic polyelectrolytes in entangled polymer solution capillary electrophoresis: the effect of binary mixtures of separating polymers differing in molecular mass.
2002 Aug
Preparation of albumin preferential surfaces on poly(vinyl chloride) membranes via surface self-segregation.
2002 Aug
X-ray reflectivity and diffraction studies on lipid and lipopolymer Langmuir-Blodgett films under controlled humidity.
2002 Aug 14
New diphosphine ligands containing ethyleneglycol and amino alcohol spacers for the rhodium-catalyzed carbonylation of methanol.
2002 Aug 2
Effects of metal ions on concentration of DNA in high-conductivity media by capillary electrophoresis.
2002 Aug 9
Vitrification media: toxicity, permeability, and dielectric properties.
2002 Feb
Phase diagram and physical properties of a waterless sodium bis(2-ethylhexylsulfosuccinate)- ethylbenzene-ethyleneglycol microemulsion: an insight into percolation.
2002 Feb
Chain-melting phase transition and short-range molecular interactions in phospholipid foam bilayers.
2002 Feb 25
Monitoring the migration behavior of living microorganisms in capillary electrophoresis using laser-induced fluorescence detection with a charge-coupled device imaging system.
2002 Jul
Prediction of benzodiazepines solubility using different cosolvency models.
2002 Jul
Characterization of poly(ethylene glycol) esters using low energy collision-induced dissociation in electrospray ionization mass spectrometry.
2002 Jul
Role of leukocytes in ethanol-induced microvascular injury in the rat brain in situ: potential role in alcohol brain pathology and stroke.
2002 Jul 12
Optimisation of a solid-phase microextraction method for synthetic musk compounds in water.
2002 Jul 19
Comparison of three different poly(dimethylsiloxane)-divinylbenzene fibres for the analysis of pesticide multiresidues in water samples: structure and efficiency.
2002 Jul 19
Size-exclusion chromatography in 1,1,1,3,3,3-hexafluoro-2-propanol.
2002 Jul 26
Electromagnetic re-warming of cryopreserved tissues: effect of choice of cryoprotectant and sample shape on uniformity of heating.
2002 Jul 7
Amplification of small analytes in polymer solution by capillary electrophoresis.
2002 Jun
Investigation on the hypoglycaemic effects of extracts of four Mexican medicinal plants in normal and alloxan-diabetic mice.
2002 Jun
Water state characterization, swelling behavior, thermal and mechanical properties of chitosan based networks.
2002 Jun
Biodegradable polyurethanes for implants. II. In vitro degradation and calcification of materials from poly(epsilon-caprolactone)-poly(ethylene oxide) diols and various chain extenders.
2002 Jun 15
Molecular modeling of poly(ethylene oxide) model cofactors; 1,3,6-tri-O-galloyl-beta- d-glucose and corilagin.
2002 Mar
Altered organ accumulation of oligonucleotides using polyethyleneimine grafted with poly(ethylene oxide) or pluronic as carriers.
2002 Mar
Hawthorn: pharmacology and therapeutic uses.
2002 Mar 1
PEO-grafting on PU/PS IPNs for enhanced blood compatibility--effect of pendant length and grafting density.
2002 May
[A comparison of effects of agents stabilizing or destroying the water structure on conformational changes of a DNA molecule in solutions exposed to gamma-irradiation].
2002 May-Jun
Inhibitory effect of supramolecular polyrotaxane-dipeptide conjugates on digested peptide uptake via intestinal human peptide transporter.
2002 May-Jun
Interaction of fibrinogen with surfaces of end-group-modified polyurethanes: a surface-specific sum-frequency-generation vibrational spectroscopy study.
2002 Nov
An improved OPLS-AA force field for carbohydrates.
2002 Nov 30
The effect of exchanging various substituents at the 2-position of 2-methoxyestradiol on cytotoxicity in human cancer cell cultures and inhibition of tubulin polymerization.
2002 Oct 10
Estimation of surface area of montmorillonite by ethylene oxide chain adsorption.
2002 Sep
A study of release mechanisms of different ophthalmic drugs from erodible ocular inserts based on poly(ethylene oxide).
2002 Sep
Possible role of calcium ions, calcium channels and calmodulin in excystation and metacystic development of Entamoeba invadens.
2002 Sep
Polymer--calcium phosphate cement composites for bone substitutes.
2002 Sep 15
Patents

Patents

03950331
20
03952017
13
03953525
11
03968228
5
03976642
1
03994905
8
03997510
1
04006179
10
04007171
2
04008269
12
04012392
9
04051261
2
Name Type Language
ETHYLENE GLYCOL
HSDB   II   MART.   MI   USP-RS   WHO-DD  
Systematic Name English
GLYCOL [INCI]
Common Name English
GLYCOL
INCI  
INCI  
Official Name English
NANOSILVER+EG
Brand Name English
ETHYLENE GLYCOL [USP-RS]
Common Name English
ETHYLENE GLYCOL [HSDB]
Common Name English
LOWENOL COPOLYMER 1985-A
Brand Name English
ETHYLENE GLYCOL [MI]
Common Name English
Ethylene glycol [WHO-DD]
Common Name English
GLYCEROL IMPURITY B [EP IMPURITY]
Common Name English
ETHYLENE GLYCOL [MART.]
Common Name English
NSC-93876
Code English
ETHANE-1,2-DIOL
Common Name English
LOWENOL COPOLYMER 1985-B
Brand Name English
PROPYLENE GLYCOL RELATED COMPOUND ETHYLENE GLYCOL [USP IMPURITY]
Common Name English
LOWENOL T-163A
Brand Name English
ETHYLENE GLYCOL [II]
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 42203
Created by admin on Sat Dec 16 20:06:31 GMT 2023 , Edited by admin on Sat Dec 16 20:06:31 GMT 2023
Code System Code Type Description
FDA UNII
FC72KVT52F
Created by admin on Sat Dec 16 20:06:31 GMT 2023 , Edited by admin on Sat Dec 16 20:06:31 GMT 2023
PRIMARY
DAILYMED
FC72KVT52F
Created by admin on Sat Dec 16 20:06:31 GMT 2023 , Edited by admin on Sat Dec 16 20:06:31 GMT 2023
PRIMARY
MESH
D019855
Created by admin on Sat Dec 16 20:06:31 GMT 2023 , Edited by admin on Sat Dec 16 20:06:31 GMT 2023
PRIMARY
CAS
107-21-1
Created by admin on Sat Dec 16 20:06:31 GMT 2023 , Edited by admin on Sat Dec 16 20:06:31 GMT 2023
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Sat Dec 16 20:06:31 GMT 2023 , Edited by admin on Sat Dec 16 20:06:31 GMT 2023
CONCEPT Industrial Aid
CHEBI
30742
Created by admin on Sat Dec 16 20:06:31 GMT 2023 , Edited by admin on Sat Dec 16 20:06:31 GMT 2023
PRIMARY
HSDB
5012
Created by admin on Sat Dec 16 20:06:31 GMT 2023 , Edited by admin on Sat Dec 16 20:06:31 GMT 2023
PRIMARY
SMS_ID
100000084884
Created by admin on Sat Dec 16 20:06:31 GMT 2023 , Edited by admin on Sat Dec 16 20:06:31 GMT 2023
PRIMARY
RS_ITEM_NUM
1265515
Created by admin on Sat Dec 16 20:06:31 GMT 2023 , Edited by admin on Sat Dec 16 20:06:31 GMT 2023
PRIMARY
ECHA (EC/EINECS)
203-473-3
Created by admin on Sat Dec 16 20:06:31 GMT 2023 , Edited by admin on Sat Dec 16 20:06:31 GMT 2023
PRIMARY
RXCUI
1314364
Created by admin on Sat Dec 16 20:06:31 GMT 2023 , Edited by admin on Sat Dec 16 20:06:31 GMT 2023
PRIMARY RxNorm
NSC
93876
Created by admin on Sat Dec 16 20:06:31 GMT 2023 , Edited by admin on Sat Dec 16 20:06:31 GMT 2023
PRIMARY
PUBCHEM
174
Created by admin on Sat Dec 16 20:06:31 GMT 2023 , Edited by admin on Sat Dec 16 20:06:31 GMT 2023
PRIMARY
NCI_THESAURUS
C77464
Created by admin on Sat Dec 16 20:06:31 GMT 2023 , Edited by admin on Sat Dec 16 20:06:31 GMT 2023
PRIMARY
MERCK INDEX
m5122
Created by admin on Sat Dec 16 20:06:31 GMT 2023 , Edited by admin on Sat Dec 16 20:06:31 GMT 2023
PRIMARY Merck Index
ChEMBL
CHEMBL457299
Created by admin on Sat Dec 16 20:06:31 GMT 2023 , Edited by admin on Sat Dec 16 20:06:31 GMT 2023
PRIMARY
EPA CompTox
DTXSID8020597
Created by admin on Sat Dec 16 20:06:31 GMT 2023 , Edited by admin on Sat Dec 16 20:06:31 GMT 2023
PRIMARY
WIKIPEDIA
ETHYLENE GLYCOL
Created by admin on Sat Dec 16 20:06:31 GMT 2023 , Edited by admin on Sat Dec 16 20:06:31 GMT 2023
PRIMARY
EVMPD
SUB21575
Created by admin on Sat Dec 16 20:06:31 GMT 2023 , Edited by admin on Sat Dec 16 20:06:31 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of ETHYLENE GLYCOL
NIH
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