Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C22H27ClN2O3 |
| Molecular Weight | 402.914 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 9 / 9 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC[C@@H]1[C@@H](O)N2[C@H]3C[C@]45[C@H](OC(=O)CCl)[C@H]3[C@H]1C[C@H]2[C@@H]4N(C)C6=CC=CC=C56
InChI
InChIKey=LAHDERDHXJFFJU-ZWNKPRIXSA-N
InChI=1S/C22H27ClN2O3/c1-3-11-12-8-15-19-22(13-6-4-5-7-14(13)24(19)2)9-16(25(15)21(11)27)18(12)20(22)28-17(26)10-23/h4-7,11-12,15-16,18-21,27H,3,8-10H2,1-2H3/t11-,12-,15-,16-,18-,19-,20+,21+,22+/m0/s1
Lorajmine is a monochloracetyl derivative of ajmaline. It is a class Ia antiarrhythmic agent that is rapidly hydrolyzed to ajmaline by plasma and tissue esterases. Lorajmine was used in the clinic to control arrhythmias. It was found that in a significant proportion of cases administration of lorajmine lead to worsening of arrhythmias.
Approval Year
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WHO-VATC |
QC01BA12
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WHO-ATC |
C01BA12
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1604
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LORAJMINE
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m6904
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47562-08-3
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76957773
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C170128
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100000082030
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SUB08579MIG
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256-322-9
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F96VX65849
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CHEMBL2111031
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DB13651
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3889
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DTXSID101023575
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
