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Details

Stereochemistry ABSOLUTE
Molecular Formula C22H27ClN2O3.ClH
Molecular Weight 439.375
Optical Activity UNSPECIFIED
Defined Stereocenters 9 / 9
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LORAJMINE HYDROCHLORIDE

SMILES

Cl.CC[C@@H]1[C@@H](O)N2[C@H]3C[C@]45[C@H](OC(=O)CCl)[C@H]3[C@H]1C[C@H]2[C@@H]4N(C)C6=CC=CC=C56

InChI

InChIKey=HNUSYDFQYYRIHJ-UUFOBPRJSA-N
InChI=1S/C22H27ClN2O3.ClH/c1-3-11-12-8-15-19-22(13-6-4-5-7-14(13)24(19)2)9-16(25(15)21(11)27)18(12)20(22)28-17(26)10-23;/h4-7,11-12,15-16,18-21,27H,3,8-10H2,1-2H3;1H/t11-,12-,15-,16-,18-,19-,20+,21+,22+;/m0./s1

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C22H27ClN2O3
Molecular Weight 402.914
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 9 / 9
E/Z Centers 0
Optical Activity UNSPECIFIED

Lorajmine is a monochloracetyl derivative of ajmaline. It is a class Ia antiarrhythmic agent that is rapidly hydrolyzed to ajmaline by plasma and tissue esterases. Lorajmine was used in the clinic to control arrhythmias. It was found that in a significant proportion of cases administration of lorajmine lead to worsening of arrhythmias.

Approval Year

Substance Class Chemical
Created
by admin
on Mon Mar 31 17:50:40 GMT 2025
Edited
by admin
on Mon Mar 31 17:50:40 GMT 2025
Record UNII
F8RIT10785
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
WIN 11831
Preferred Name English
LORAJMINE HYDROCHLORIDE
MART.   MI   USAN   WHO-DD  
USAN  
Official Name English
Lorajmine hydrochloride [WHO-DD]
Common Name English
LORAJMINE HYDROCHLORIDE [MART.]
Common Name English
AJMALAN-17,21-DIOL, 17-(CHLOROACETATE), MONOHYDROCHLORIDE, (17R,21.ALPHA.)-
Common Name English
LORAJMINE HYDROCHLORIDE [MI]
Common Name English
Ajmaline 17-(chloroacetate) monohydrochloride
Common Name English
WIN-11831
Code English
LORAJMINE HCL
Common Name English
LORAJMINE HYDROCHLORIDE [USAN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C47793
Created by admin on Mon Mar 31 17:50:40 GMT 2025 , Edited by admin on Mon Mar 31 17:50:40 GMT 2025
Code System Code Type Description
SMS_ID
100000086152
Created by admin on Mon Mar 31 17:50:40 GMT 2025 , Edited by admin on Mon Mar 31 17:50:40 GMT 2025
PRIMARY
NCI_THESAURUS
C83893
Created by admin on Mon Mar 31 17:50:40 GMT 2025 , Edited by admin on Mon Mar 31 17:50:40 GMT 2025
PRIMARY
EVMPD
SUB02972MIG
Created by admin on Mon Mar 31 17:50:40 GMT 2025 , Edited by admin on Mon Mar 31 17:50:40 GMT 2025
PRIMARY
PUBCHEM
76960253
Created by admin on Mon Mar 31 17:50:40 GMT 2025 , Edited by admin on Mon Mar 31 17:50:40 GMT 2025
PRIMARY
FDA UNII
F8RIT10785
Created by admin on Mon Mar 31 17:50:40 GMT 2025 , Edited by admin on Mon Mar 31 17:50:40 GMT 2025
PRIMARY
EPA CompTox
DTXSID90961232
Created by admin on Mon Mar 31 17:50:40 GMT 2025 , Edited by admin on Mon Mar 31 17:50:40 GMT 2025
PRIMARY
ChEMBL
CHEMBL2111031
Created by admin on Mon Mar 31 17:50:40 GMT 2025 , Edited by admin on Mon Mar 31 17:50:40 GMT 2025
PRIMARY
MERCK INDEX
m6904
Created by admin on Mon Mar 31 17:50:40 GMT 2025 , Edited by admin on Mon Mar 31 17:50:40 GMT 2025
PRIMARY Merck Index
CAS
40819-93-0
Created by admin on Mon Mar 31 17:50:40 GMT 2025 , Edited by admin on Mon Mar 31 17:50:40 GMT 2025
PRIMARY
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