Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C15H14ClN3O3 |
| Molecular Weight | 319.743 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCOC(=O)C1=C2CN(C)C(=O)C3=C(Cl)C=CC=C3N2C=N1
InChI
InChIKey=WSDBAFQWNWJTNG-UHFFFAOYSA-N
InChI=1S/C15H14ClN3O3/c1-3-22-15(21)13-11-7-18(2)14(20)12-9(16)5-4-6-10(12)19(11)8-17-13/h4-6,8H,3,7H2,1-2H3
Sarmazenil (previously known as RO 153505) was developed as a weak inverse agonist at the omega modulatory sites (benzodiazepine receptors). This compound is used in veterinary medicine in order to rapidly re-awake anesthetized animals. In addition, this compound was studied in the treatment of a moxidectin intoxication in foals. Sarmazenil was also involved in preclinical development for Alzheimer's disease in the USA. However, the information about the further development of the drug is not available.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Sarmazenil-precipitated withdrawal: a reliable method for assessing dependence liability of benzodiazepine receptor ligands. | 1998 Apr |
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| Partial antagonism of tiletamine-zolazepam anesthesia in cheetah. | 2002 Apr |
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| Effects of midazolam and sarmazenil on the equine electroencephalogram during anaesthesia with halothane in oxygen. | 2003 Apr |
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| The use of sarmazenil in the treatment of a moxidectin intoxication in a foal. | 2005 May-Jun |
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| Balanced anesthesia and ventilation strategies for an alpaca (Lama pacos) with an increased anesthetic-risk. | 2008 Feb |
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| Anaesthesia for the geriatric dog and cat. | 2008 Jun 1 |
Patents
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Official Name | English | ||
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Code | English | ||
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Code | English |
| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C28197
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WHO-VATC |
QV03AB91
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F84AE7X24P
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78771-13-8
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SARMAZENIL
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CHEMBL46547
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SUB10452MIG
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C73206
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6283
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100000084077
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DTXSID70229281
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71231
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ACTIVE MOIETY
