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Details

Stereochemistry RACEMIC
Molecular Formula C11H16N2O2
Molecular Weight 208.2569
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SAFRAZINE

SMILES

CC(CCC1=CC=C2OCOC2=C1)NN

InChI

InChIKey=IBWPUTAKVGZXRB-UHFFFAOYSA-N
InChI=1S/C11H16N2O2/c1-8(13-12)2-3-9-4-5-10-11(6-9)15-7-14-10/h4-6,8,13H,2-3,7,12H2,1H3

HIDE SMILES / InChI
Safrazine (Safra) is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class that was introduced as an antidepressant in the 1960s. Safrazine and electroconvulsive therapy were shown to be effective in the treatment of antidepressant-resistant depressions (ARD) but had the drawbacks of the high incidence of moderate or severe adverse reactions and high relapse rates, respectively. The use of safrazine was discontinued.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
PubMed

PubMed

TitleDatePubMed
Comparative studies of the effects of RS-8359 and safrazine on monoamine oxidase in-vitro and in-vivo in mouse brain.
1989 Jan

Sample Use Guides

Nocturnal periodic hypoxemia occurring in a 25-year-old Duchenne muscular dystrophy patient under NIPPV control was successfully treated with monoamine oxydase inhibitor (MAOI), safrazine hydrochloride. Five mg of safrazine hydrochloride was administered before sleep, and the periodic hypoxemia disappeared within 14 days.
Route of Administration: Oral
Name Type Language
SAFRAZINE
WHO-DD  
Common Name English
Safrazine [WHO-DD]
Common Name English
SAPHRAZINE, (±)-
Common Name English
(±)-SAPHRAZINE
Common Name English
SAPHRAZINE
Common Name English
.BETA.-PIPERONYLISOPROPYLHYDRAZINE
Common Name English
HYDRAZINE, (1-METHYL-3-(3,4-(METHYLENEDIOXY)PHENYL)PROPYL)
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C667
Created by admin on Fri Dec 15 17:17:21 GMT 2023 , Edited by admin on Fri Dec 15 17:17:21 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID60860006
Created by admin on Fri Dec 15 17:17:21 GMT 2023 , Edited by admin on Fri Dec 15 17:17:21 GMT 2023
PRIMARY
MESH
C013242
Created by admin on Fri Dec 15 17:17:21 GMT 2023 , Edited by admin on Fri Dec 15 17:17:21 GMT 2023
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DRUG BANK
DB09253
Created by admin on Fri Dec 15 17:17:21 GMT 2023 , Edited by admin on Fri Dec 15 17:17:21 GMT 2023
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PUBCHEM
34042
Created by admin on Fri Dec 15 17:17:21 GMT 2023 , Edited by admin on Fri Dec 15 17:17:21 GMT 2023
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CAS
33419-68-0
Created by admin on Fri Dec 15 17:17:21 GMT 2023 , Edited by admin on Fri Dec 15 17:17:21 GMT 2023
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WIKIPEDIA
Safrazine
Created by admin on Fri Dec 15 17:17:21 GMT 2023 , Edited by admin on Fri Dec 15 17:17:21 GMT 2023
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SMS_ID
100000078388
Created by admin on Fri Dec 15 17:17:21 GMT 2023 , Edited by admin on Fri Dec 15 17:17:21 GMT 2023
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NCI_THESAURUS
C84141
Created by admin on Fri Dec 15 17:17:21 GMT 2023 , Edited by admin on Fri Dec 15 17:17:21 GMT 2023
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EVMPD
SUB15175MIG
Created by admin on Fri Dec 15 17:17:21 GMT 2023 , Edited by admin on Fri Dec 15 17:17:21 GMT 2023
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FDA UNII
F5G0P5378C
Created by admin on Fri Dec 15 17:17:21 GMT 2023 , Edited by admin on Fri Dec 15 17:17:21 GMT 2023
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