RIBOFLAVIN TETRABUTYRATE

First approved in 2018

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C33H44N4O10
Molecular Weight	656.7233
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCC(=O)OC[C@@H](OC(=O)CCC)[C@@H](OC(=O)CCC)[C@H](CN1C2=NC(=O)NC(=O)C2=NC3=C1C=C(C)C(C)=C3)OC(=O)CCC

InChI

InChIKey=MJNIWUJSIGSWKK-BBANNHEPSA-N

InChI=1S/C33H44N4O10/c1-7-11-25(38)44-18-24(46-27(40)13-9-3)30(47-28(41)14-10-4)23(45-26(39)12-8-2)17-37-22-16-20(6)19(5)15-21(22)34-29-31(37)35-33(43)36-32(29)42/h15-16,23-24,30H,7-14,17-18H2,1-6H3,(H,36,42,43)/t23-,24+,30-/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.daiichisankyo-hc.co.jp/package_insert_foreign/pdf/traful_bb_charge-en.pdf
Curator's Comment: Description was created based on several sources, including https://www.drugs.com/mtm/vitamin-b2.html and https://examine.com/supplements/vitamin-b2/

Riboflavin butyrate (a vitamin B2 derivative used widely in Japan) is often an ingredient of multivitamin complexes, used for relief of following symptoms: stomatitis, glossitis, perleche, cheilitis, rough skin, acne, dermatitis, eczema, rash, sores. It is a supply of Vitamins B2 and B6 in the following situations: physical fatigue, pregnancy/lactation, decline of physical strength during or after illness.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Potency
platelet aggregation 76 Target ID: GO:0070527 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3999460	Inhibitor 8297
Skin tumorigenesis 1 Target ID: Skin tumorigenesis Sources: https://www.ncbi.nlm.nih.gov/pubmed/7117737	Inhibitor 8297
Lipid peroxidation 2 Target ID: Lipid peroxidation Sources: https://www.ncbi.nlm.nih.gov/pubmed/4032070	Inhibitor 8297
Giardia lamblia WB strain 1 Target ID: Giardia lamblia WB strain Sources: https://www.ncbi.nlm.nih.gov/pubmed/25267663	Inhibitor 8297	1.09 µM [IC50]

Conditions

Condition	Modality	Highest Phase	Product
Pigmentation disorders 2 Sources: http://takeda-kenko.jp/en/products/vitamin/hic_l.html	Primary	Approved 8429	HICEE L Approved Use Relief of the following symptoms: Blotches, freckles and pigmentation due to sunlight or rash. Prevention of the following bleeding symptoms: Bleeding of the gum and bleeding of the nose
Stomatitis 7 Sources: https://www.daiichisankyo-hc.co.jp/package_insert_foreign/pdf/traful_bb_charge-en.pdf	Primary	Approved 8429	Traful BB Charge Approved Use Indications Relief of following symptoms: Stomatitis, glossitis, perleche, cheilitis, rough skin, acne, dermatitis, eczema, rash, sores Supply of Vitamins B2 and B6 in the following situations: Physical fatigue, pregnancy/lactation, decline of physical strength during or after illness
Eczema 46 Sources: https://www.daiichisankyo-hc.co.jp/package_insert_foreign/pdf/traful_bb_charge-en.pdf	Primary	Approved 8429	Traful BB Charge Approved Use Indications Relief of following symptoms: Stomatitis, glossitis, perleche, cheilitis, rough skin, acne, dermatitis, eczema, rash, sores Supply of Vitamins B2 and B6 in the following situations: Physical fatigue, pregnancy/lactation, decline of physical strength during or after illness
Vitamin B2 deficiency 3 Sources: http://www.mims.com/hongkong/drug/info/hibon	Primary	Approved 8429	Hibon Approved Use dietary supplement

PubMed

Title	Date	PubMed
Absorption and fluorescence spectra of riboflavin tetrabutyrate in various solvents.	1967 Mar	6053315
[Studies on riboflavin tetrabutyrate (B2-But) and its effects on p-dimethylaminoazobenzene (DAB) induced hepatoma or degenerated liver of the rat; ESR spectra of the subfraction of lipoperoxide extracted from the liver and several enzyme activities of the same tissue].	1968 Apr 10	4300949
Studies on fatty acid esters of flavins. VII. Reaction of riboflavin tetrabutyrate with linoleic acid under ultra violet light irradiation.	1970 Dec 10	5497914

Patents

Sample Use Guides

In Vivo Use Guide

Adults (15 years or over) 2 tablets once daily. 2 tablets contain 20 mg of Riboflavin Tetrabutyrate

Route of Administration: Oral

In Vitro Use Guide

Riboflavin Tetrabutyrate inhibited, in vitro, ADP-induced platelet aggregation when added at the concentration of more than 1 ug/ml and arachidonic acid (Aa) (1 mM)-induced platelet aggregation when given at the concentration of more than 0.1 ug/ml.

Name

Type

Language

RIBOFLAVIN TETRABUTYRATE

Official Name

English

VIRAS

Brand Name

English

TETRA-O-BUTYRYLRIBOFLAVIN

Common Name

English

LACFLAVIN

Brand Name

English

VITAMIN B2 2',3',4',5'-TETRABUTYRATE

Common Name

English

RIBOFLAVIN 2', 3', 4', 5'-TETRABUTYRATE

Common Name

English

RIBOFLAVIN, 2',3',4',5'-TETRABUTANOATE

Common Name

English

RIBOFLAVIN TETRABUTYRATE [INCI]

Common Name

English

WAKAFLAVIN L

Brand Name

English

RIBOFLAVIN 2',3',4',5'-TETRABUTYRATE

Common Name

English

BITUVITAN

Brand Name

English

RIBOFLAVIN BUTYRATE [JAN]

Common Name

English

Riboflavin tetrabutyrate [WHO-DD]

Common Name

English

RIBOFLAVIN 2', 3', 4', 5'-TETRABUTYRATE [MI]

Common Name

English

RIBOFLAVIN BUTYRATE

Common Name

English

VITAMIN B2 TETRABUTYRATE

Common Name

English

Code System Code Type Description

DRUG BANK

DB14727