Details
Stereochemistry | MIXED |
Molecular Formula | C20H37O7S.Na |
Molecular Weight | 444.558 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 0 / 3 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].CCCCC(CC)COC(=O)CC(C(=O)OCC(CC)CCCC)S([O-])(=O)=O
InChI
InChIKey=APSBXTVYXVQYAB-UHFFFAOYSA-M
InChI=1S/C20H38O7S.Na/c1-5-9-11-16(7-3)14-26-19(21)13-18(28(23,24)25)20(22)27-15-17(8-4)12-10-6-2;/h16-18H,5-15H2,1-4H3,(H,23,24,25);/q;+1/p-1
Docusate, also known as docusate salts or dioctyl sulfosuccinate, prevents/relieves dry hard stool and thus is used to treat constipation. Results usually occurs 1 to 3 days after the first dose. In North America, docusate and a stimulant laxative such as sennosides are commonly used in bowel treatment protocols associated with institutionalized elderly and oncology treatments. A paucity of evidence is available to support the use of the stool softener docusate yet it continues to be prescribed in everyday clinical practice for the aforementioned populations. While the actual cost of docusate is low, additional costs associated with its administration (i.e. nursing time) and its widespread use can be significant. Docusate is absorbed into the bloodstream and excreted via the gallbladder after undergoing extensive metabolism. The effect of docusate may not necessarily be all due to its surfactant properties. Perfusion studies suggest that docusate inhibits fluid absorption or stimulates secretion in the portion of the small intestine known as the jejunum
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Comparative study of the photophysical behavior of fisetin in homogeneous media and in anionic and cationic reverse micelles media. | 2007 May-Jun |
|
Characterization of multifunctional reverse micelles' interfaces using hemicyanines as molecular probes. II: Effect of the surfactant. | 2009 May 14 |
|
Modulation of excited-state proton-transfer reactions of 7-hydroxy-4-methylcoumarin in ionic and nonionic reverse micelles. | 2009 May 14 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.drugs.com/dosage/docusate.html
Usual Adult Dose for Constipation:
Oral: 50 to 400 mg (using any of the salt forms) orally administered in 1 to 4 equally divided doses each day.
Rectal: 200 to 283 mg rectally administered as an enema once or twice. Alternative: 50 to 100 mg (docusate sodium liquid) added to a retention or flushing enema once a day.
Usual Pediatric Dose for Constipation:
Oral: less than 3 years: 10 to 40 mg (docusate sodium) orally divided in 1 to 4 doses. 3 to 6 years: 20 to 60 mg (docusate sodium) orally divided in 1 to 4 doses. 6 to 12 years: 40 to 150 mg (docusate sodium) orally divided in 1 to 4 doses. greater than 12 years: 50 to 400 mg (using any of the salt forms) orally administered in 1 to 4 equally divided doses each day.
Rectal: 3 to 18 years: 50 to 100 mg (docusate sodium liquid) added to a retention or flushing enema once a day. Alternative: 200 to 283 mg rectally administered as an enema once daily as needed for constipation.
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11530185
It was evaluated the efficacy and toxicity of docusate against herpes simplex viruses (HSV). Docusate was effective in vitro against wild type and drug-resistant strains of HSV type 1 and 2 with EC(90-100) (effective concentration giving 90-100% virus yield reduction) of approximately 0.005% (w/v). The cytotoxicity profiles of docusate were time- and dose-dependent and thus associated with the frequency of use. Kinetics of inactivation examined by pre-mixing virus and drug in a time-course experiment demonstrated that docusate could reach its EC(90-100) within 30 min.
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Brand Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Brand Name | English | ||
|
Code | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Brand Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Official Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Brand Name | English | ||
|
Brand Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Brand Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
WHO-ATC |
A06AG10
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
||
|
CODEX ALIMENTARIUS (GSFA) |
INS-480
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
||
|
CFR |
21 CFR 176.170
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
||
|
WHO-VATC |
QA06AG10
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
||
|
CFR |
21 CFR 172.520
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
||
|
JECFA EVALUATION |
INS-480
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
||
|
CFR |
21 CFR 172.810
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
||
|
CFR |
21 CFR 175.320
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
||
|
WHO-VATC |
QA06AA02
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
||
|
WHO-ATC |
A06AA02
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
||
|
NCI_THESAURUS |
C29699
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
||
|
WHO-ESSENTIAL MEDICINES LIST |
8.4
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
||
|
DSLD |
3169 (Number of products:31)
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
6
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
PRIMARY | |||
|
531
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
PRIMARY | |||
|
C460182
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
PRIMARY | |||
|
m4716
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
PRIMARY | Merck Index | ||
|
23673837
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
PRIMARY | |||
|
CHEMBL1477036
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
PRIMARY | |||
|
1224802
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
PRIMARY | |||
|
577-11-7
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
PRIMARY | |||
|
C29000
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
PRIMARY | |||
|
F05Q2T2JA0
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
PRIMARY | |||
|
F05Q2T2JA0
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
PRIMARY | |||
|
71722
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
PRIMARY | RxNorm | ||
|
941
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
PRIMARY | |||
|
DTXSID8022959
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
PRIMARY | |||
|
209-406-4
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
PRIMARY | |||
|
3065
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
PRIMARY | |||
|
133817
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
PRIMARY | |||
|
SUB06348MIG
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
PRIMARY | |||
|
DBSALT001500
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
PRIMARY | |||
|
DIOCTYL SODIUM SULFOSUCCINATE
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
PRIMARY | |||
|
760404
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
PRIMARY | |||
|
100000092012
Created by
admin on Fri Dec 15 15:01:22 GMT 2023 , Edited by admin on Fri Dec 15 15:01:22 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD