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Details

Stereochemistry ACHIRAL
Molecular Formula 2Cl.Co
Molecular Weight 129.839
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of COBALTOUS CHLORIDE

SMILES

[Cl-].[Cl-].[Co++]

InChI

InChIKey=GVPFVAHMJGGAJG-UHFFFAOYSA-L
InChI=1S/2ClH.Co/h2*1H;/q;;+2/p-2

HIDE SMILES / InChI

Description
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/104729ISBN 9780873715980, Foden C.R., Weddell J.L., 'Hazardous Materials: Emergency Action Data' (1991), Retrieved from https://books.google.com/books?id=4IPE8Pjhm8UC&pgISBN: 978-94-010-7024-9, Matar M.S., Mirbach M.J.,Tayim H.A. 'Catalysis in Petrochemical Processes' (1988), p.136, Retrieved from https://books.google.com/books?id=MkD2JnDkZYYC&dqhttp://aygrt.isrj.org/colorArticles/4972.pdfhttp://onlinelibrary.wiley.com/doi/10.1002/3527600418.mb744048e0023/pdfhttps://www.ncbi.nlm.nih.gov/pubmed/27527840https://fscimage.fishersci.com/msds/05330.htmhttp://laboratorychemicals.in/uploads/msds/10026-17-2-49128.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/2253206https://monographs.iarc.fr/ENG/Monographs/vol52/mono52-16.pdfhttp://datasheets.scbt.com/sc-227251.pdf
Curator's Comment: description was created based on several sources, including: DOI:10.1080/00958970802416020 | DOI:10.1080/00958972.2010.521553 | https://www.ncbi.nlm.nih.gov/pubmed/7201957 | https://www.ncbi.nlm.nih.gov/pubmed/18475879

Cobaltous iodide is a catalyst used in organic synthesis.

Originator

Brandt, G.
20
Curator's Comment: Cobalt was discovered by Georg Brandt, a Swedish chemist, in 1739.

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Hypoxia-inducible factor 1-alpha inhibitor
22
Target ID: Q9NWT6
Gene ID: 55662.0
Gene Symbol: HIF1AN
Target Organism: Homo sapiens (Human)
Inhibitor
8297
 1.0 µM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Withdrawn
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Erythropoietic effect of cobalt in patients with or without anemia.
1949 May 12
Cobalt iontophoresis techniques for tracing afferent and efferent connections in the vertebrate CNS.
1975 May 2
Inhalation toxicity studies of cobalt sulfate in F344/N rats and B6C3F1 mice.
1990 Aug
Determination of trace metal ions in common salt by stripping voltammetry.
1999 Nov-Dec
Cobalt and antimony: genotoxicity and carcinogenicity.
2003 Dec 10
Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway.
2005 Aug
In vitro assessment of cobalt oxide particle toxicity: identifying and circumventing interference.
2013 Sep
Patents

Patents

US20150010463
20
US3459677 A
20
US4326084
20
US5718844
20
US6740618 B2
20
WO2014127808A1
20

Sample Use Guides

In Vivo Use Guide
For treatment of anemia, oral cobal chloride was administered at doses 25 mg and 50 mg daily.
Route of Administration: Oral
In Vitro Use Guide
HIF asparaginyl hydroxylase activity was measured by a method based on the hydroxylation coupled decarboxylation of 2-oxoglutarate with the synthetic HIF-1α peptides in the presence of varying concentrations of Co (1-5 uM). Ki for HIF asparaginyl hydroxylase was 1uM.
Name Type Language
COBALTOUS CHLORIDE
HSDB   MI  
Common Name English
COBALT DICHLORIDE (COCL2)
Common Name English
COBALT CHLORIDE [INCI]
Common Name English
Cobalt chloride [WHO-DD]
Common Name English
DICHLOROCOBALT
Systematic Name English
COBALTOUS CHLORIDE [MI]
Common Name English
COBALT DICHLORIDE
Systematic Name English
COBALTUM MURIATICUM [HPUS]
Common Name English
COBALT(II) CHLORIDE
Systematic Name English
COBALTOUS DICHLORIDE
Common Name English
COBALTOUS CHLORIDE [HSDB]
Common Name English
NSC-51149
Code English
COBALT CHLORIDE [MART.]
Common Name English
COBALT CHLORIDE
INCI   MART.   WHO-DD  
INCI  
Official Name English
COBALT CHLORIDE (COCL2)
Common Name English
COBALTUM MURIATICUM
HPUS  
Common Name English
Classification Tree Code System Code
CFR 21 CFR 189.120
Created by admin on Fri Dec 15 15:50:27 GMT 2023 , Edited by admin on Fri Dec 15 15:50:27 GMT 2023
Code System Code Type Description
FDA UNII
EVS87XF13W
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PRIMARY
EPA CompTox
DTXSID9040180
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PRIMARY
CHEBI
35696
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PRIMARY
NCI_THESAURUS
C45678
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CONCEPT Industrial Aid
EVMPD
SUB13408MIG
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PRIMARY
MESH
C018021
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PRIMARY
DRUG BANK
DB14206
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PRIMARY
DAILYMED
EVS87XF13W
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PRIMARY
HSDB
1000
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PRIMARY
CAS
7646-79-9
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PRIMARY
RXCUI
1426884
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PRIMARY RxNorm
ECHA (EC/EINECS)
231-589-4
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PRIMARY
WIKIPEDIA
COBALT(II) CHLORIDE
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PRIMARY
MERCK INDEX
m3691
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PRIMARY Merck Index
NSC
51149
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PRIMARY
NCI_THESAURUS
C77458
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PRIMARY
PUBCHEM
24288
Created by admin on Fri Dec 15 15:50:27 GMT 2023 , Edited by admin on Fri Dec 15 15:50:27 GMT 2023
PRIMARY
SUBSTANCE RECORD
Structure of COBALTOUS CHLORIDE
NIH
NCATS
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