U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula O2Si
Molecular Weight 60.0842
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SILICON DIOXIDE

SMILES

O=[Si]=O

InChI

InChIKey=VYPSYNLAJGMNEJ-UHFFFAOYSA-N
InChI=1S/O2Si/c1-3-2

HIDE SMILES / InChI

Description
Curator's Comment:: description was created based on several sources, including https://web.archive.org/web/20130418061428/http://www.accessdata.fda.gov/scripts/fcn/gras_notices/GRN000321.pdf

Silicon dioxide (silica) is most commonly found in nature as quartz, as well as in various living organisms. Silicon dioxide one of the most complex and most abundant families of materials, existing both as several minerals and being produced synthetically. In food and pharmaceutical industry silica is a common additive, where it is used primarily as a flow in powdered foods, or to adsorb water in hygroscopic application. In pharmaceutical products, silica aids powder flow when tablets are formed.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
Oxycodone Hydrochloride

Approved Use

Oxycodone is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics.

Launch Date

9.0935997E11
Primary
Silicol gel

Approved Use

Silicol gel is an oral gel containing colloidal silicic acid for the treatment of gastrointestinal disorders. Taken 3 times a day it helps manage symptoms and provides relief for gastrointestinal discomfort.
Primary
GELUSIL

Approved Use

Uses Relieves: heartburn sour stomach acid indigestion bloating, pressure and discomfort commonly referred to as gas

Launch Date

1.22221442E12
PubMed

PubMed

TitleDatePubMed
Increased expression of manganese-containing superoxide dismutase in rat lungs after inhalation of inflammatory and fibrogenic minerals.
1994 Mar
Silicate antibodies in women with silicone breast implants: development of an assay for detection of humoral immunity.
1996 Mar
Emergency room visits for respiratory conditions in children increased after Guagua Pichincha volcanic eruptions in April 2000 in Quito, Ecuador observational study: time series analysis.
2007 Jul 24
Calcitonin gene-related peptide (CGRP) as hazard marker for lung injury induced by dusts.
2007 Mar
Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles.
2007 May
Quartz inhibits glucose 6-phosphate dehydrogenase in murine alveolar macrophages.
2008 Apr
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.
2008 Aug
Curcumin protects against cytotoxic and inflammatory effects of quartz particles but causes oxidative DNA damage in a rat lung epithelial cell line.
2008 Feb 15
Genetic polymorphisms of IL-1A, IL-1B, IL-1RN, NFKB1, FAS, and FASL, and risk of silicosis in a Chinese occupational population.
2008 Nov
Ascorbic acid pre-treated quartz stimulates TNF-alpha release in RAW 264.7 murine macrophages through ROS production and membrane lipid peroxidation.
2009 Mar 19
Cytokine and chemokine expression patterns in lung epithelial cells exposed to components characteristic of particulate air pollution.
2009 May 2
Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cells.
2009 Oct
Oxidative stress of silica nanoparticles in human bronchial epithelial cell, Beas-2B.
2009 Oct
Role of IL-1 beta and COX2 in silica-induced IL-6 release and loss of pneumocytes in co-cultures.
2009 Oct
Investigation of the cytotoxic and proinflammatory effects of cement dusts in rat alveolar macrophages.
2009 Sep
Nano-SiO2 induces apoptosis via activation of p53 and Bax mediated by oxidative stress in human hepatic cell line.
2010 Apr
IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis.
2010 Jun 1
Inhibition of a protein tyrosine phosphatase using mesoporous oxides.
2010 Mar 11
Blood gene expression profiling detects silica exposure and toxicity.
2011 Aug
Altered microRNAs expression profiling in experimental silicosis rats.
2012
Aryl hydrocarbon receptor (AhR) regulates silica-induced inflammation but not fibrosis.
2012 Apr
Silica nanoparticles and silver-doped silica nanoparticles induce endoplasmatic reticulum stress response and alter cytochrome P4501A activity.
2012 Apr
Apoptosis induction by silica nanoparticles mediated through reactive oxygen species in human liver cell line HepG2.
2012 Mar 1
Methylation of PARP-1 promoter involved in the regulation of nano-SiO2-induced decrease of PARP-1 mRNA expression.
2012 Mar 25
Mechanisms of toxicity of amorphous silica nanoparticles on human lung submucosal cells in vitro: protective effects of fisetin.
2012 Oct 15
Activation of Egr-1 in human lung epithelial cells exposed to silica through MAPKs signaling pathways.
2013
New insight into artifactual phenomena during in vitro toxicity assessment of engineered nanoparticles: study of TNF-α adsorption on alumina oxide nanoparticle.
2013 Apr
Molecular insights into the progression of crystalline silica-induced pulmonary toxicity in rats.
2013 Apr
The NLRP3 inflammasome affects DNA damage responses after oxidative and genotoxic stress in dendritic cells.
2013 Aug
Transcriptional responses of human aortic endothelial cells to nanoconstructs used in biomedical applications.
2013 Aug 5
Cellular internalization and stress response of ingested amorphous silica nanoparticles in the midgut of Drosophila melanogaster.
2013 Jan
Toxicogenomic analysis of the particle dose- and size-response relationship of silica particles-induced toxicity in mice.
2013 Jan 11
Biological effects induced by BSA-stabilized silica nanoparticles in mammalian cell lines.
2013 Jun 25
Neutralization of interleukin-1 beta attenuates silica-induced lung inflammation and fibrosis in C57BL/6 mice.
2013 Nov
Suppression of thioredoxin system contributes to silica-induced oxidative stress and pulmonary fibrogenesis in rats.
2013 Oct 9
PDGF-D expression is down-regulated by TGFβ in fibroblasts.
2014
Involvement of P2Y11 receptor in silica nanoparticles 30-induced IL-6 production by human keratinocytes.
2014 Aug 1
Silica nanoparticles induce cytokine responses in lung epithelial cells through activation of a p38/TACE/TGF-α/EGFR-pathway and NF-κΒ signalling.
2014 Aug 15
Uptake of silica nanoparticles: neurotoxicity and Alzheimer-like pathology in human SK-N-SH and mouse neuro2a neuroblastoma cells.
2014 Aug 17
Inflammation and gene expression in the rat lung after instillation of silica nanoparticles: effect of size, dispersion medium and particle surface charge.
2014 Jan 3
Purinergic signaling via P2X7 receptor mediates IL-1β production in Kupffer cells exposed to silica nanoparticle.
2014 Jul 3
Role of size and surface area for pro-inflammatory responses to silica nanoparticles in epithelial lung cells: importance of exposure conditions.
2014 Mar
Si/SiO2 quantum dots cause cytotoxicity in lung cells through redox homeostasis imbalance.
2014 Sep 5
miR-98 and its host gene Huwe1 target Caspase-3 in Silica nanoparticles-treated male germ cells.
2015 Aug 11
Toxicity, genotoxicity and proinflammatory effects of amorphous nanosilica in the human intestinal Caco-2 cell line.
2015 Mar
Aberrant cytokinesis and cell fusion result in multinucleation in HepG2 cells exposed to silica nanoparticles.
2015 Mar 16
Role of human pulmonary fibroblast-derived MCP-1 in cell activation and migration in experimental silicosis.
2015 Oct 15
Complex responses to Si quantum dots accumulation in carp liver tissue: Beyond oxidative stress.
2015 Sep 5
Common and distinct mechanisms of induced pulmonary fibrosis by particulate and soluble chemical fibrogenic agents.
2016 Feb
Effects of silica exposure on the cardiac and renal inflammatory and fibrotic response and the antagonistic role of interleukin-1 beta in C57BL/6 mice.
2016 Feb
Patents

Sample Use Guides

In Vivo Use Guide
To treat gastrointestinal disorders, take one tablespoon (15ml) of silicol®gel (containing silicic acid which is a compound of silicon and oxygen) three times daily, preferably before mealtimes. After acute symptoms ease, treatment is recommended for another few days. For chronic conditions, treat for up to four weeks and then take a break to re-assess symptoms.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
SILICON DIOXIDE
DASH   FCC   II   VANDF   WHO-DD  
Common Name English
SILICATE [VANDF]
Common Name English
SYLOID SILICA GEL [VANDF]
Common Name English
SILICON DIOXIDE COMPONENT OF SIMETHICONE
Common Name English
SILICON DIOXIDE, AMORPHOUS
Common Name English
SAND [INCI]
Common Name English
SAND
INCI  
INCI  
Official Name English
SILICA GEL [WHO-DD]
Common Name English
SYLOID 244 [VANDF]
Common Name English
SILICA GEL [VANDF]
Common Name English
SILICA, AMORPHOUS [IARC]
Common Name English
SILICONE DIOXIDE [VANDF]
Common Name English
SILICON DIOXIDE [VANDF]
Common Name English
SILICA [INCI]
Common Name English
SILICA GEL
VANDF   WHO-DD  
Common Name English
SILICON DIOXIDE [II]
Common Name English
SIMETHICONE COMPONENT SILICON DIOXIDE
Common Name English
SILICA
INCI  
INCI  
Official Name English
E-551
Code English
SILICON DIOXIDE [FCC]
Common Name English
SILICON DIOXIDE [WHO-DD]
Common Name English
INS NO.551
Code English
INS-551
Code English
SILICA AEROGEL
Common Name English
Classification Tree Code System Code
CFR 21 CFR 178.3297
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
DSLD 2042 (Number of products:1)
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
CFR 21 CFR 176.170
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
CODEX ALIMENTARIUS (GSFA) INS-551
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
EPA PESTICIDE CODE 72605
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
EPA PESTICIDE CODE 72602
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
JECFA EVALUATION INS-551
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
DSLD 209 (Number of products:67)
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
CFR 21 CFR 172.230
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 401
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 329
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
CFR 21 CFR 172.480
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
Food Contact Sustance Notif, (FCN No.) FCN NO. 155
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
Code System Code Type Description
EVMPD
SUB15238MIG
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
PRIMARY
PUBCHEM
24261
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
PRIMARY
RXCUI
1311243
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
ALTERNATIVE
WIKIPEDIA
SILICON DIOXIDE
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
PRIMARY
MESH
D012822
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
PRIMARY
MESH
D012824
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
PRIMARY
EVMPD
SUB47557
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
PRIMARY
CAS
63231-67-4
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
ALTERNATIVE
CAS
7631-86-9
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
PRIMARY
ECHA (EC/EINECS)
231-545-4
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
PRIMARY
DRUG BANK
DB14138
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
PRIMARY
EVMPD
SUB15239MIG
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
PRIMARY
EPA CompTox
63231-67-4
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
PRIMARY
CAS
14808-60-7
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
ALTERNATIVE
MERCK INDEX
M9902
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
PRIMARY Merck Index
EVMPD
SUB171236
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
PRIMARY
FDA UNII
ETJ7Z6XBU4
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
PRIMARY
EVMPD
SUB20041
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
PRIMARY
DRUG CENTRAL
4284
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
PRIMARY
NCI_THESAURUS
C29853
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
PRIMARY
JECFA MONOGRAPH
INS-551
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
PRIMARY
EVMPD
SUB171092
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
PRIMARY
RXCUI
9771
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
PRIMARY
ChEMBL
CHEMBL2108563
Created by admin on Sat Jun 26 01:12:43 UTC 2021 , Edited by admin on Sat Jun 26 01:12:43 UTC 2021
PRIMARY