U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula O2Si
Molecular Weight 60.0843
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SILICON DIOXIDE

SMILES

O=[Si]=O

InChI

InChIKey=VYPSYNLAJGMNEJ-UHFFFAOYSA-N
InChI=1S/O2Si/c1-3-2

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including https://web.archive.org/web/20130418061428/http://www.accessdata.fda.gov/scripts/fcn/gras_notices/GRN000321.pdf

Silicon dioxide (silica) is most commonly found in nature as quartz, as well as in various living organisms. Silicon dioxide one of the most complex and most abundant families of materials, existing both as several minerals and being produced synthetically. In food and pharmaceutical industry silica is a common additive, where it is used primarily as a flow in powdered foods, or to adsorb water in hygroscopic application. In pharmaceutical products, silica aids powder flow when tablets are formed.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
Oxycodone Hydrochloride

Approved Use

Oxycodone is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics.

Launch Date

9.0935997E11
Primary
Silicol gel

Approved Use

Silicol gel is an oral gel containing colloidal silicic acid for the treatment of gastrointestinal disorders. Taken 3 times a day it helps manage symptoms and provides relief for gastrointestinal discomfort.
Primary
GELUSIL

Approved Use

Uses Relieves: heartburn sour stomach acid indigestion bloating, pressure and discomfort commonly referred to as gas

Launch Date

1.22221442E12
PubMed

PubMed

TitleDatePubMed
[Scleroderma and environment. I. Scleroderma and sclerodermiform states induced by silica and chemical agents or drugs].
1991
Enhanced fatty acid biosynthesis and normal surfactant secretion in hypertrophic rat type II cells.
1991 Jun
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis.
2003 Jun 15
Characterization of the effect of interleukin-10 on silica-induced lung fibrosis in mice.
2004 Jul
[Effect of niacin on nitric oxide synthase expression in rat lung exposed to silica].
2004 May
Pulmonary bioassay studies with nanoscale and fine-quartz particles in rats: toxicity is not dependent upon particle size but on surface characteristics.
2007 Jan
Emergency room visits for respiratory conditions in children increased after Guagua Pichincha volcanic eruptions in April 2000 in Quito, Ecuador observational study: time series analysis.
2007 Jul 24
Calcitonin gene-related peptide (CGRP) as hazard marker for lung injury induced by dusts.
2007 Mar
Curcumin protects against cytotoxic and inflammatory effects of quartz particles but causes oxidative DNA damage in a rat lung epithelial cell line.
2008 Feb 15
Genetic polymorphisms of IL-1A, IL-1B, IL-1RN, NFKB1, FAS, and FASL, and risk of silicosis in a Chinese occupational population.
2008 Nov
Internalization, cytotoxicity, apoptosis, and tumor necrosis factor-alpha expression in rat alveolar macrophages exposed to various dusts occurring in the ceramics industry.
2008 Sep
Attenuation of silica-induced pulmonary fibroblasts proliferation by taurine and niacin in vitro.
2009 Apr
Critical role of MARCO in crystalline silica-induced pulmonary inflammation.
2009 Apr
Pulmonary toxicity of multi-walled carbon nanotubes (Baytubes) relative to alpha-quartz following a single 6h inhalation exposure of rats and a 3 months post-exposure period.
2009 Dec 21
Macrophage responses to silica nanoparticles are highly conserved across particle sizes.
2009 Feb
Differential binding of inorganic particles to MARCO.
2009 Jan
Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro.
2009 Jan 10
Ascorbic acid pre-treated quartz stimulates TNF-alpha release in RAW 264.7 murine macrophages through ROS production and membrane lipid peroxidation.
2009 Mar 19
Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cells.
2009 Oct
Epigenetic mediated transcriptional activation of PARP-1 participates in silica-associated malignant transformation of human bronchial epithelial cells.
2010 Apr 1
IL-6 receptor-mediated lung Th2 cytokine networking in silica-induced pulmonary fibrosis.
2010 Dec
Airway exposure to silica-coated TiO2 nanoparticles induces pulmonary neutrophilia in mice.
2010 Feb
Inhibition of a protein tyrosine phosphatase using mesoporous oxides.
2010 Mar 11
Does vitreous silica contradict the toxicity of the crystalline silica paradigm?
2010 Mar 15
Nanotoxicity of pure silica mediated through oxidant generation rather than glutathione depletion in human lung epithelial cells.
2010 Oct 9
Blood gene expression profiling detects silica exposure and toxicity.
2011 Aug
Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling.
2011 Dec
Cytotoxicity and mitochondrial damage caused by silica nanoparticles.
2011 Dec
Platelet-derived growth factor-producing CD4+ Foxp3+ regulatory T lymphocytes promote lung fibrosis.
2011 Dec 1
Lung fibrosis induced by crystalline silica particles is uncoupled from lung inflammation in NMRI mice.
2011 Jun 10
Altered microRNAs expression profiling in experimental silicosis rats.
2012
Aryl hydrocarbon receptor (AhR) regulates silica-induced inflammation but not fibrosis.
2012 Apr
Silica nanoparticles and silver-doped silica nanoparticles induce endoplasmatic reticulum stress response and alter cytochrome P4501A activity.
2012 Apr
Transcriptomics analysis of lungs and peripheral blood of crystalline silica-exposed rats.
2012 Aug
Long-lasting oxidative pulmonary insult in rat after intratracheal instillation of silica nanoparticles doped with cadmium.
2012 Dec 16
Immunostimulatory effects of gold nanorod and silica-coated gold nanorod on RAW 264.7 mouse macrophages.
2012 Feb 25
Occupational and environmental cancer incidence and mortality in China.
2012 Jun
Four types of inorganic nanoparticles stimulate the inflammatory reaction in brain microglia and damage neurons in vitro.
2012 Oct 17
Implication of oxidative stress in size-dependent toxicity of silica nanoparticles in kidney cells.
2012 Sep 28
Activation of Egr-1 in human lung epithelial cells exposed to silica through MAPKs signaling pathways.
2013
Molecular insights into the progression of crystalline silica-induced pulmonary toxicity in rats.
2013 Apr
Transcriptional responses of human aortic endothelial cells to nanoconstructs used in biomedical applications.
2013 Aug 5
Toxicogenomic analysis of the particle dose- and size-response relationship of silica particles-induced toxicity in mice.
2013 Jan 11
Evaluation of immunohistochemical markers to detect the genotoxic mode of action of fine and ultrafine dusts in rat lungs.
2013 Jan 7
Interactions of silica nanoparticles with lung epithelial cells and the association to flotillins.
2013 Jun
PDGF-D expression is down-regulated by TGFβ in fibroblasts.
2014
Silica nanoparticles induce cytokine responses in lung epithelial cells through activation of a p38/TACE/TGF-α/EGFR-pathway and NF-κΒ signalling.
2014 Aug 15
Uptake of silica nanoparticles: neurotoxicity and Alzheimer-like pathology in human SK-N-SH and mouse neuro2a neuroblastoma cells.
2014 Aug 17
Si/SiO2 quantum dots cause cytotoxicity in lung cells through redox homeostasis imbalance.
2014 Sep 5
miR-98 and its host gene Huwe1 target Caspase-3 in Silica nanoparticles-treated male germ cells.
2015 Aug 11
Patents

Sample Use Guides

In Vivo Use Guide
To treat gastrointestinal disorders, take one tablespoon (15ml) of silicol®gel (containing silicic acid which is a compound of silicon and oxygen) three times daily, preferably before mealtimes. After acute symptoms ease, treatment is recommended for another few days. For chronic conditions, treat for up to four weeks and then take a break to re-assess symptoms.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
SILICON DIOXIDE
DASH   FCC   II   VANDF   WHO-DD  
Common Name English
Silicon dioxide [WHO-DD]
Common Name English
SILICATE [VANDF]
Common Name English
SYLOID SILICA GEL [VANDF]
Common Name English
SILICON DIOXIDE COMPONENT OF SIMETHICONE
Common Name English
SILICON DIOXIDE, AMORPHOUS
Common Name English
SAND [INCI]
Common Name English
SAND
INCI  
INCI  
Official Name English
SYLOID 244 [VANDF]
Common Name English
SILICA GEL [VANDF]
Common Name English
SILICA, AMORPHOUS [IARC]
Common Name English
SILICONE DIOXIDE [VANDF]
Common Name English
SILICON DIOXIDE [VANDF]
Common Name English
SILICA [INCI]
Common Name English
SILICA GEL
VANDF   WHO-DD  
Common Name English
SILICON DIOXIDE [II]
Common Name English
SIMETHICONE COMPONENT SILICON DIOXIDE
Common Name English
Silica
INCI  
INCI  
Official Name English
E-551
Code English
SILICON DIOXIDE [FCC]
Common Name English
INS NO.551
Code English
Silica gel [WHO-DD]
Common Name English
INS-551
Code English
SILICA AEROGEL
Common Name English
Classification Tree Code System Code
CFR 21 CFR 178.3297
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
DSLD 2042 (Number of products:1)
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
CFR 21 CFR 176.170
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
CODEX ALIMENTARIUS (GSFA) INS-551
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
EPA PESTICIDE CODE 72605
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
EPA PESTICIDE CODE 72602
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
JECFA EVALUATION INS-551
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
DSLD 209 (Number of products:67)
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
CFR 21 CFR 172.230
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 401
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 329
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
CFR 21 CFR 172.480
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 155
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
Code System Code Type Description
DAILYMED
ETJ7Z6XBU4
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY
CHEBI
26675
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY
EVMPD
SUB15238MIG
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY
PUBCHEM
24261
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY
SMS_ID
100000091508
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY
RXCUI
1311243
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
ALTERNATIVE
WIKIPEDIA
SILICON DIOXIDE
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY
MESH
D012822
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY
MESH
D012824
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY
EVMPD
SUB47557
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY
CAS
63231-67-4
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
ALTERNATIVE
CHEBI
29241
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY
CAS
7631-86-9
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY
ECHA (EC/EINECS)
231-545-4
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY
DRUG BANK
DB14138
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY
EVMPD
SUB15239MIG
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY
EPA CompTox
DTXSID1029677
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY
CAS
14808-60-7
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
ALTERNATIVE
MERCK INDEX
m9902
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY Merck Index
EVMPD
SUB171236
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY
FDA UNII
ETJ7Z6XBU4
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY
CHEBI
30563
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY
EVMPD
SUB20041
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY
DRUG CENTRAL
4284
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY
NCI_THESAURUS
C29853
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY
ALANWOOD
silica gel
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY
EVMPD
SUB171092
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY
RXCUI
9771
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY
ChEMBL
CHEMBL2108563
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY
GRAS Notification (GRN No.)
298
Created by admin on Fri Dec 15 16:12:14 UTC 2023 , Edited by admin on Fri Dec 15 16:12:14 UTC 2023
PRIMARY