U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula O2Si
Molecular Weight 60.0843
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SILICON DIOXIDE

SMILES

O=[Si]=O

InChI

InChIKey=VYPSYNLAJGMNEJ-UHFFFAOYSA-N
InChI=1S/O2Si/c1-3-2

HIDE SMILES / InChI

Molecular Formula O2Si
Molecular Weight 60.0843
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://web.archive.org/web/20130418061428/http://www.accessdata.fda.gov/scripts/fcn/gras_notices/GRN000321.pdf

Silicon dioxide (silica) is most commonly found in nature as quartz, as well as in various living organisms. Silicon dioxide one of the most complex and most abundant families of materials, existing both as several minerals and being produced synthetically. In food and pharmaceutical industry silica is a common additive, where it is used primarily as a flow in powdered foods, or to adsorb water in hygroscopic application. In pharmaceutical products, silica aids powder flow when tablets are formed.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
Oxycodone Hydrochloride

Approved Use

Oxycodone is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics.

Launch Date

9.0935997E11
Primary
Silicol gel

Approved Use

Silicol gel is an oral gel containing colloidal silicic acid for the treatment of gastrointestinal disorders. Taken 3 times a day it helps manage symptoms and provides relief for gastrointestinal discomfort.
Primary
GELUSIL

Approved Use

Uses Relieves: heartburn sour stomach acid indigestion bloating, pressure and discomfort commonly referred to as gas

Launch Date

1.22221442E12
PubMed

PubMed

TitleDatePubMed
[Scleroderma and environment. I. Scleroderma and sclerodermiform states induced by silica and chemical agents or drugs].
1991
Enhanced fatty acid biosynthesis and normal surfactant secretion in hypertrophic rat type II cells.
1991 Jun
Quartz exposure of the rat lung leads to a linear dose response in inflammation but not in oxidative DNA damage and mutagenicity.
2001 Apr
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis.
2003 Jun 15
Gene expression of surfactant protein-A and thyroid transcription factor-1 in lungs of rats exposed to silicon-carbide whisker in vivo.
2003 Sep
Ascorbic acid-pretreated quartz enhances cyclo-oxygenase-2 expression in RAW 264.7 murine macrophages.
2007 Jan
Pulmonary bioassay studies with nanoscale and fine-quartz particles in rats: toxicity is not dependent upon particle size but on surface characteristics.
2007 Jan
Calcitonin gene-related peptide (CGRP) as hazard marker for lung injury induced by dusts.
2007 Mar
Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles.
2007 May
Genetic polymorphisms of IL-1A, IL-1B, IL-1RN, NFKB1, FAS, and FASL, and risk of silicosis in a Chinese occupational population.
2008 Nov
Attenuation of silica-induced pulmonary fibroblasts proliferation by taurine and niacin in vitro.
2009 Apr
Macrophage responses to silica nanoparticles are highly conserved across particle sizes.
2009 Feb
Formation of a vitreous phase at the surface of some commercial diatomaceous earth prevents the onset of oxidative stress effects.
2009 Jan
Ascorbic acid pre-treated quartz stimulates TNF-alpha release in RAW 264.7 murine macrophages through ROS production and membrane lipid peroxidation.
2009 Mar 19
Cytokine and chemokine expression patterns in lung epithelial cells exposed to components characteristic of particulate air pollution.
2009 May 2
Crystalline silica Min-U-Sil 5 induces oxidative stress in human bronchial epithelial cells BEAS-2B by reducing the efficiency of antiglycation and antioxidant enzymatic defenses.
2009 Nov 10
Oxidative stress of silica nanoparticles in human bronchial epithelial cell, Beas-2B.
2009 Oct
Investigation of the cytotoxic and proinflammatory effects of cement dusts in rat alveolar macrophages.
2009 Sep
Inhibition of a protein tyrosine phosphatase using mesoporous oxides.
2010 Mar 11
Blood gene expression profiling detects silica exposure and toxicity.
2011 Aug
Surface iron inhibits quartz-induced cytotoxic and inflammatory responses in alveolar macrophages.
2011 Jan 14
Lung fibrosis induced by crystalline silica particles is uncoupled from lung inflammation in NMRI mice.
2011 Jun 10
Altered microRNAs expression profiling in experimental silicosis rats.
2012
Immunostimulatory effects of gold nanorod and silica-coated gold nanorod on RAW 264.7 mouse macrophages.
2012 Feb 25
Implication of oxidative stress in size-dependent toxicity of silica nanoparticles in kidney cells.
2012 Sep 28
New insight into artifactual phenomena during in vitro toxicity assessment of engineered nanoparticles: study of TNF-α adsorption on alumina oxide nanoparticle.
2013 Apr
The NLRP3 inflammasome affects DNA damage responses after oxidative and genotoxic stress in dendritic cells.
2013 Aug
Toxicogenomic analysis of the particle dose- and size-response relationship of silica particles-induced toxicity in mice.
2013 Jan 11
Interactions of silica nanoparticles with lung epithelial cells and the association to flotillins.
2013 Jun
Biological effects induced by BSA-stabilized silica nanoparticles in mammalian cell lines.
2013 Jun 25
Involvement of P2Y11 receptor in silica nanoparticles 30-induced IL-6 production by human keratinocytes.
2014 Aug 1
Uptake of silica nanoparticles: neurotoxicity and Alzheimer-like pathology in human SK-N-SH and mouse neuro2a neuroblastoma cells.
2014 Aug 17
Inflammation and gene expression in the rat lung after instillation of silica nanoparticles: effect of size, dispersion medium and particle surface charge.
2014 Jan 3
Purinergic signaling via P2X7 receptor mediates IL-1β production in Kupffer cells exposed to silica nanoparticle.
2014 Jul 3
miR-98 and its host gene Huwe1 target Caspase-3 in Silica nanoparticles-treated male germ cells.
2015 Aug 11
Common and distinct mechanisms of induced pulmonary fibrosis by particulate and soluble chemical fibrogenic agents.
2016 Feb
Effects of silica exposure on the cardiac and renal inflammatory and fibrotic response and the antagonistic role of interleukin-1 beta in C57BL/6 mice.
2016 Feb
Patents

Sample Use Guides

In Vivo Use Guide
To treat gastrointestinal disorders, take one tablespoon (15ml) of silicol®gel (containing silicic acid which is a compound of silicon and oxygen) three times daily, preferably before mealtimes. After acute symptoms ease, treatment is recommended for another few days. For chronic conditions, treat for up to four weeks and then take a break to re-assess symptoms.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Wed Jul 05 23:39:44 UTC 2023
Edited
by admin
on Wed Jul 05 23:39:44 UTC 2023
Record UNII
ETJ7Z6XBU4
Record Status Validated (UNII)
Record Version
  • Download
Related Record Type
Name Type Language
SILICON DIOXIDE
DASH   FCC   II   VANDF   WHO-DD  
Common Name English
Silicon dioxide [WHO-DD]
Common Name English
SILICATE [VANDF]
Common Name English
SYLOID SILICA GEL [VANDF]
Common Name English
SILICON DIOXIDE COMPONENT OF SIMETHICONE
Common Name English
SILICON DIOXIDE, AMORPHOUS
Common Name English
SAND [INCI]
Common Name English
SAND
INCI  
INCI  
Official Name English
SYLOID 244 [VANDF]
Common Name English
SILICA GEL [VANDF]
Common Name English
SILICA, AMORPHOUS [IARC]
Common Name English
SILICONE DIOXIDE [VANDF]
Common Name English
SILICON DIOXIDE [VANDF]
Common Name English
SILICA [INCI]
Common Name English
SILICA GEL
VANDF   WHO-DD  
Common Name English
SILICON DIOXIDE [II]
Common Name English
SIMETHICONE COMPONENT SILICON DIOXIDE
Common Name English
Silica
INCI  
INCI  
Official Name English
E-551
Code English
SILICON DIOXIDE [FCC]
Common Name English
INS NO.551
Code English
Silica gel [WHO-DD]
Common Name English
INS-551
Code English
SILICA AEROGEL
Common Name English
Classification Tree Code System Code
CFR 21 CFR 178.3297
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
DSLD 2042 (Number of products:1)
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
CFR 21 CFR 176.170
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
CODEX ALIMENTARIUS (GSFA) INS-551
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
EPA PESTICIDE CODE 72605
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
EPA PESTICIDE CODE 72602
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
JECFA EVALUATION INS-551
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
DSLD 209 (Number of products:67)
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
CFR 21 CFR 172.230
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 401
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 329
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
CFR 21 CFR 172.480
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 155
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
Code System Code Type Description
DAILYMED
ETJ7Z6XBU4
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
CHEBI
26675
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
EVMPD
SUB15238MIG
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
PUBCHEM
24261
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
SMS_ID
100000091508
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
RXCUI
1311243
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
ALTERNATIVE
WIKIPEDIA
SILICON DIOXIDE
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
MESH
D012822
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
MESH
D012824
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
EVMPD
SUB47557
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
CAS
63231-67-4
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
ALTERNATIVE
CHEBI
29241
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
CAS
7631-86-9
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
ECHA (EC/EINECS)
231-545-4
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
DRUG BANK
DB14138
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
EVMPD
SUB15239MIG
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
EPA CompTox
DTXSID1029677
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
CAS
14808-60-7
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
ALTERNATIVE
MERCK INDEX
M9902
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY Merck Index
EVMPD
SUB171236
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
FDA UNII
ETJ7Z6XBU4
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
CHEBI
30563
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
EVMPD
SUB20041
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
DRUG CENTRAL
4284
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
NCI_THESAURUS
C29853
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
JECFA MONOGRAPH
INS-551
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
ALANWOOD
silica gel
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
EVMPD
SUB171092
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
RXCUI
9771
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
ChEMBL
CHEMBL2108563
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
GRAS Notification (GRN No.)
298
Created by admin on Wed Jul 05 23:39:44 UTC 2023 , Edited by admin on Wed Jul 05 23:39:44 UTC 2023
PRIMARY
Related Record Type Details
SUB_CONCEPT->SUBSTANCE
SUB_CONCEPT->SUBSTANCE
SUB_CONCEPT->SUBSTANCE
SUB_CONCEPT->SUBSTANCE
SOLVATE->ANHYDROUS
SUB_CONCEPT->SUBSTANCE
SUB_CONCEPT->SUBSTANCE
SUB_CONCEPT->SUBSTANCE
Related Record Type Details
PARENT -> IMPURITY
Related Record Type Details
ACTIVE MOIETY