Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C23H25N3O2 |
| Molecular Weight | 375.4635 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O=C1CC2=CC3=C(ON=C3CCC4CCN(CC5=CC=CC=C5)CC4)C=C2N1
InChI
InChIKey=MTCMTKNMZCPKLX-UHFFFAOYSA-N
InChI=1S/C23H25N3O2/c27-23-13-18-12-19-20(25-28-22(19)14-21(18)24-23)7-6-16-8-10-26(11-9-16)15-17-4-2-1-3-5-17/h1-5,12,14,16H,6-11,13,15H2,(H,24,27)
Icopezil (previously known as CP-118,954) was developed as a selective acetylcholinesterase inhibitor for the treatment of cognitive disorders. Phase II trials of icopezil were underway in Japan and in the USA for the treatment of patients with Alzheimer's disease. However, Pfizer has discontinued these studies.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Synthesis and evaluation of radioiodine-labelled CP-118,954 for the in-vivo imaging of acetylcholinesterase. | 2007-07 |
|
| Synthesis and evaluation of 2-[18F]fluoro-CP-118,954 for the in vivo mapping of acetylcholinesterase. | 2005-02 |
|
| Synthesis and evaluation of 5,7-dihydro-3-[2-[1-(4-[18F]-fluorobenzyl)-4-piperidinyl]ethyl]-6H-pyrrolo[3,2-f]-1,2-benzisoxazol-6-one for in vivo mapping of acetylcholinesterase. | 2004-06 |
Patents
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Official Name | English | ||
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Preferred Name | English | ||
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Common Name | English | ||
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Systematic Name | English |
| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C47792
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
