Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H26N2O3 |
| Molecular Weight | 294.3892 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCOC1=C(C=CC(N)=C1)C(=O)OCCN(CC)CC
InChI
InChIKey=CAJIGINSTLKQMM-UHFFFAOYSA-N
InChI=1S/C16H26N2O3/c1-4-10-20-15-12-13(17)7-8-14(15)16(19)21-11-9-18(5-2)6-3/h7-8,12H,4-6,9-11,17H2,1-3H3
Propoxycaine hydrochloride is a local anesthetic of the ester type that has a rapid onset of action and a longer duration of action than procaine hydrochloride. Propoxycaine Hydrochloride is the hydrochloride salt form of propoxycaine, a para-aminobenzoic acid ester. Propoxycaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. This results in a loss of sensation.
Approval Year
Overview
| CYP3A4 | CYP2C9 | CYP2D6 | hERG |
|---|---|---|---|
OverviewOther
| Other Inhibitor | Other Substrate | Other Inducer |
|---|---|---|
Drug as perpetrator​
| Target | Modality | Activity | Metabolite | Clinical evidence |
|---|---|---|---|---|
| no [Activation >10 uM] | ||||
| no [Activation >10 uM] | ||||
| no [Activation >10 uM] | ||||
| yes [Activation 1.99526 uM] | ||||
| yes [Activation 12.58925 uM] |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Does instilling proxymetacaine before cyclopentolate significantly reduce stinging? The implications of paediatric cycloplegia. | 2001 Feb |
|
| Local anaesthesia for vitreoretinal surgery: an audit of patient and surgical experience. | 2001 Oct-Dec |
|
| The efficacy of 0.5% proparacaine stored at room temperature. | 2001 Sep |
|
| Allergic contact dermatitis to proparacaine with subsequent cross-sensitization to tetracaine from ophthalmic preparations. | 2001 Sep |
|
| In vivo transscleral iontophoresis of amikacin to rabbit eyes. | 2002 Dec |
|
| [A subjective evaluation of epibulbar and etrobulbar anesthesia in cataract phacoemulsification]. | 2005 Jan-Feb |
|
| Efficacy of sucrose to reduce pain in premature infants during eye examinations for retinopathy of prematurity. | 2005 Jun |
|
| Randomised controlled trial of sub-Tenon's block versus topical anaesthesia for cataract surgery: a comparison of patient satisfaction. | 2005 Mar |
|
| Flap suturing with proparacaine for recurrent epithelial ingrowth following laser in situ keratomileusis surgery. | 2005 May |
|
| Efficacy of topical anesthetics to reduce pain in premature infants during eye examinations for retinopathy of prematurity. | 2005 May |
|
| Comparison of corneal thickness after the instillation of topical anesthetics: proparacaine versus oxybuprocaine. | 2006 Jan |
|
| Prospective randomized double-masked trial to evaluate perioperative pain profile in different stages of simultaneous bilateral LASIK. | 2006 Sep |
|
| Topical anesthesia in transconjunctival sutureless 25-gauge vitrectomy for macular-based disorders. | 2007 |
|
| [Self-medication with local anaesthetics by glaucoma patients using teletonometry]. | 2007 Dec |
|
| An assessment of the discomfort associated with the use of rose bengal 1% eyedrops on the normal human eye: a comparison with saline 0.9% and a topical ocular anaesthetic. | 2007 Mar |
|
| Does prior instillation of a topical anaesthetic alter the pupillary mydriasis produced by tropicamide (0.5%)? | 2007 May |
|
| Analgesic efficacy of single-dose parecoxib for corneal suturing in children. | 2007 May |
|
| Adjustable suture strabismus surgery in infants and children. | 2008 Dec |
|
| Anterior sub-Tenon's anesthesia for the treatment of retinopathy of prematurity. | 2008 May-Jun |
|
| Patient comfort and surgeon satisfaction during cataract surgery using topical anesthesia with or without dexmedetomidine sedation. | 2008 May-Jun |
|
| Topology of a ternary complex (proparacaine-beta-cyclodextrin-liposome) by STD NMR. | 2008 Sep |
|
| Prolonged corneal anaesthesia by proxymetacaine hydrochloride detected by a thermal cooling stimulus. | 2009 Apr |
|
| Ring keratitis associated with topical abuse of a dilute anesthetic after refractive surgery. | 2009 Dec |
|
| Liquid nitrogen cryotherapy of superior limbic keratoconjunctivitis. | 2009 Feb |
|
| Comparative study of analgesic effectiveness using three different anesthetic techniques for intravitreal injection of bevacizumab. | 2009 Jan-Feb |
|
| Topical proparacaine and episcleral venous pressure in the rabbit. | 2009 Jun |
|
| Intrathecal oxybuprocaine and proxymetacaine produced potent and long-lasting spinal anesthesia in rats. | 2009 May 1 |
|
| Proparacaine complexation with beta-cyclodextrin and p-sulfonic acid calix[6]arene, as evaluated by varied (1)H-NMR approaches. | 2009 Sep |
|
| Light sensitivity and pain sensation during cataract surgery. A comparative study of two modes of anaesthesia. | 2010 Dec |
|
| Ocular blood-flow hemodynamics before and after application of a laser in situ keratomileusis ring. | 2010 Feb |
|
| The reuse of opthalmic Minims: an unacceptable cross-infection risk? | 2010 Jan |
|
| The systemic toxicity of equipotent proxymetacaine, oxybuprocaine, and bupivacaine during continuous intravenous infusion in rats. | 2010 Jan 1 |
|
| Pain management during eye examinations for retinopathy of prematurity in preterm infants: a systematic review. | 2010 Mar |
|
| Dilute proparacaine for the management of acute corneal injuries in the emergency department. | 2010 Sep |
Patents
| Name | Type | Language | ||
|---|---|---|---|---|
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Official Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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NCI_THESAURUS |
C245
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EPD1EH7F53
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CHEMBL1195
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86-43-1
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D011430
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PROPOXYCAINE
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3496
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201-670-9
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6843
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100000081362
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DTXSID6047866
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319
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DB09342
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C66492
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SUB10118MIG
Created by
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
