Details
Stereochemistry | ACHIRAL |
Molecular Formula | C12H16N2.C4H4O4 |
Molecular Weight | 304.341 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 1 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)\C=C\C(O)=O.CN(C)CCC1=CNC2=CC=CC=C12
InChI
InChIKey=OHMVTPSXVQQKPA-WLHGVMLRSA-N
InChI=1S/C12H16N2.C4H4O4/c1-14(2)8-7-10-9-13-12-6-4-3-5-11(10)12;5-3(6)1-2-4(7)8/h3-6,9,13H,7-8H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL214 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1828347 |
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Target ID: CHEMBL2096662 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9768567 |
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Target ID: CHEMBL2095158 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27216487 |
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Target ID: CHEMBL2094251 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27216487 |
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Target ID: CHEMBL231 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27216487 |
PubMed
Title | Date | PubMed |
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A proposed mechanism for the visions of dream sleep. | 1988 Jun |
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Dose-response study of N,N-dimethyltryptamine in humans. I. Neuroendocrine, autonomic, and cardiovascular effects. | 1994 Feb |
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[Antimycobacterial indole derivatives]. | 1994 Feb |
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Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan. | 1996 Dec |
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Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor. | 1996 Jan |
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Psychedelic effects of ketamine in healthy volunteers: relationship to steady-state plasma concentrations. | 1998 Jan |
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DMT at fifty. | 2007 Dec |
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A quantitative synthesis of the medicinal ethnobotany of the Malinké of Mali and the Asháninka of Peru, with a new theoretical framework. | 2007 Dec 5 |
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The globalization of ayahuasca: harm reduction or benefit maximization? | 2008 Aug |
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Secondary metabolites from three Florida sponges with antidepressant activity. | 2008 Feb |
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Comparison of the separation of nine tryptamine standards based on gas chromatography, high performance liquid chromatography and capillary electrophoresis methods. | 2008 Feb 15 |
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A general approach to the screening and confirmation of tryptamines and phenethylamines by mass spectral fragmentation. | 2008 Jan 15 |
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Mismatch negativity generation in the human 5HT2A agonist and NMDA antagonist model of psychosis. | 2008 Jul |
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Halogenated solvent interactions with N,N-dimethyltryptamine: formation of quaternary ammonium salts and their artificially induced rearrangements during analysis. | 2008 Jul 4 |
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The "vine of the soul" vs. the Controlled Substances Act: implications of the hoasca case. | 2008 Jun |
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[Inhibition of return in schizophrenia: a review]. | 2008 Jun |
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[Hallucinogen-induced psychological disorders]. | 2008 Jun |
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Indolealkylamines: biotransformations and potential drug-drug interactions. | 2008 Jun |
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Ayahuasca versus violence--a case report. | 2008 May |
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N,N-Dimethyltryptamine and dichloromethane: rearrangement of quaternary ammonium salt product during GC-EI and CI-MS-MS analysis. | 2008 May 12 |
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Pharmacological modulation of the neural basis underlying inhibition of return (IOR) in the human 5-HT2A agonist and NMDA antagonist model of psychosis. | 2008 Nov |
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Modification of the effects of 5-methoxy-N,N-dimethyltryptamine on exploratory behavior in rats by monoamine oxidase inhibitors. | 2008 Nov |
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Identification of N,N-dimethyltryptamine and beta-carbolines in psychotropic ayahuasca beverage. | 2008 Oct |
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[Studies on constituents of rootsanel leaves from Desmodium blandum and their cytotoxic activity against growth of several tumor cells]. | 2008 Sep |
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Reassessing the cultural and psychopharmacological significance of Banisteriopsis caapi: preparation, classification and use among the Piaroa of Southern Venezuela. | 2008 Sep |
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Serotonin 5-HT(2A) Receptor Function as a Contributing Factor to Both Neuropsychiatric and Cardiovascular Diseases. | 2009 |
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A multi-component LC-MS/MS method for detection of ten plant-derived psychoactive substances in urine. | 2009 Apr 15 |
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Characterisation of a proposed internet synthesis of N,N-dimethyltryptamine using liquid chromatography/electrospray ionisation tandem mass spectrometry. | 2009 Aug 14 |
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Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transporter and the vesicle monoamine transporter. | 2009 Dec |
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Optimization of separation and online sample concentration of N,N-dimethyltryptamine and related compounds using MEKC. | 2009 Feb |
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The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator. | 2009 Feb 13 |
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Bioanalytical and clinical evaluation of 103 suspected cases of intoxications with psychoactive plant materials. | 2009 Jul |
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Comparison of the discriminative stimulus effects of dimethyltryptamine with different classes of psychoactive compounds in rats. | 2009 Jul |
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[Simple and rapid screening for psychotropic natural products using Direct Analysis in Real Time (DART)-TOFMS]. | 2009 Jun |
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When the endogenous hallucinogenic trace amine N,N-dimethyltryptamine meets the sigma-1 receptor. | 2009 Mar 10 |
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Analysis of toxic alkaloids in body samples. | 2009 Mar 10 |
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Gas chromatographic analysis of dimethyltryptamine and beta-carboline alkaloids in ayahuasca, an Amazonian psychoactive plant beverage. | 2009 Mar-Apr |
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Predicting new molecular targets for known drugs. | 2009 Nov 12 |
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The neural correlates of religious and nonreligious belief. | 2009 Oct 1 |
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Sigma receptors in oncology: therapeutic and diagnostic applications of sigma ligands. | 2010 |
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Psychometric evaluation of the altered states of consciousness rating scale (OAV). | 2010 Aug 31 |
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The chemical basis of pharmacology. | 2010 Dec 7 |
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Antioxidant effects of ethyl acetate extract of Desmodium gangeticum root on myocardial ischemia reperfusion injury in rat hearts. | 2010 Jan 22 |
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Characterization of the synthesis of N,N-dimethyltryptamine by reductive amination using gas chromatography ion trap mass spectrometry. | 2010 Jul |
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Alkaloids from Fissistigma latifolium (Dunal) Merr. | 2010 Jun 24 |
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Tinnitus psychopharmacology: A comprehensive review of its pathomechanisms and management. | 2010 Jun 24 |
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Association between Serotonin-Related Polymorphisms in 5HT2A, TPH1, TPH2 Genes and Bipolar Disorder in Korean Population. | 2010 Mar |
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Neuronal correlates of visual and auditory alertness in the DMT and ketamine model of psychosis. | 2010 Oct |
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Dimethyltryptamine (DMT): subjective effects and patterns of use among Australian recreational users. | 2010 Sep 1 |
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The hallucinogenic world of tryptamines: an updated review. | 2015 Aug |
Patents
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DTXSID0048896
Created by
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EP5189LWFM
Created by
admin on Sat Dec 16 08:46:51 GMT 2023 , Edited by admin on Sat Dec 16 08:46:51 GMT 2023
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68677-26-9
Created by
admin on Sat Dec 16 08:46:51 GMT 2023 , Edited by admin on Sat Dec 16 08:46:51 GMT 2023
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60196335
Created by
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300000047760
Created by
admin on Sat Dec 16 08:46:51 GMT 2023 , Edited by admin on Sat Dec 16 08:46:51 GMT 2023
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ACTIVE MOIETY
SUBSTANCE RECORD